Mostrar el registro sencillo del ítem
resumen
Resumen
Specific mutations in the conserved domains of the acetolactate synthase (ALS) gene conduct to different key amino acid substitutions that can confer herbicide resistance in different plant species. This outcome has been widely exploited to produce herbicide-resistant agronomic crops as well as to direct many genome editing studies. Therefore, the ALS gene has become a model sequence target to improve our technological skills for more precise CRISPR/Cas
[ver mas...]
dc.contributor.author | Darqui, Flavia Soledad | |
dc.contributor.author | Hopp, Horacio Esteban | |
dc.contributor.author | Lopez Bilbao, Marisa Gisela | |
dc.date.accessioned | 2020-09-16T17:47:50Z | |
dc.date.available | 2020-09-16T17:47:50Z | |
dc.date.issued | 2020-08 | |
dc.identifier.issn | 2637-7659 | |
dc.identifier.other | http://doi.org/10.31031/MCDA.2020.07.000656 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/7913 | |
dc.identifier.uri | https://crimsonpublishers.com/mcda/fulltext/MCDA.000656.php | |
dc.description.abstract | Specific mutations in the conserved domains of the acetolactate synthase (ALS) gene conduct to different key amino acid substitutions that can confer herbicide resistance in different plant species. This outcome has been widely exploited to produce herbicide-resistant agronomic crops as well as to direct many genome editing studies. Therefore, the ALS gene has become a model sequence target to improve our technological skills for more precise CRISPR/Cas nucleotide base substitution in plants, which is essential for modulation/modification of gene function as opposed to the more general gene knock out obtained by indels in conventional genome editing studies. This review summarizes the main knowledge and experiences attained from the use of the ALS gene as a target in CRISPR/Cas studies. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Crimson Publishers | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Modern Concepts & Developments in Agronomy 7 (2) : 700-711 (Agosto 2020) | es_AR |
dc.subject | Mutagenesis | eng |
dc.subject | Mutagénesis | es_AR |
dc.subject | Amino Acids | eng |
dc.subject | Aminoácidos | es_AR |
dc.subject | Resistance to Herbicides | eng |
dc.subject | Resistencia a los Herbicidas | es_AR |
dc.subject | Genes | es_AR |
dc.subject.other | Acetolactate Synthase | eng |
dc.subject.other | Acetolactato Sintasa | es_AR |
dc.title | The ALS gene as genetic target in CRISPR/ cas approaches: what have we learned so far? | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Darqui, Flavia Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Hopp, Horacio Esteban. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina | es_AR |
dc.description.fil | Fil: Lopez Bilbao, Marisa Gisela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.subtype | cientifico |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
common
-
Artículos científicos [398]