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A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity
(Nature Publishing Group, 2023-10)Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwide. This virus ... -
Bovine colostral cells—the often forgotten component of colostrum
(American Veterinary Medical Association, 2017-05)At birth, neonatal calves have all the essential immune components they need as adult cattle; however, it takes at least 2 to 4 weeks for those components to become fully functional.1,2 The immune system does not become ... -
Immune response and protection provided by live tachyzoites and native antigens from the NC-6 Argentina strain of Neospora caninum in pregnant heifers
(Elsevier, 2013-11)The aim of the present study was to compare the immunogenicity and protective efficacy of live tachyzoites and native antigen extract obtained from the NC-6 Argentina strain against vertical transmission of Neospora caninum, ... -
Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus
(BMC, 2021-05)Background: Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the ...