Browsing Artículos científicos by Author
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Browsing Artículos científicos by Author "27316422697"
Now showing items 1-6 of 6
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A direct high-throughput in Cell-ELISA for measuring infectivity of cytopathic and non-cytopathic bovine viral diarrhoea virus strains applied to the assessment of antiviral activity
Quintana, Maria Eugenia; Barone, Lucas; Forlenza, María Belén; Trotta, Myrian Vanesa; Turco, Cecilia; Mansilla, Florencia Celeste; Cardoso, Nancy Patricia; Capozzo, Alejandra Victoria (Elsevier, 2018-07-19)Low-cost high-throughput methods applicable to any virus strain are required for screening antiviral compounds against multiple field strains. Colorimetric cell-viability assays are used for this purpose as long as the ... -
Fusion of foreign T-cell epitopes and addition of TLR agonists enhance immunity against Neospora caninum profilin in cattle
Mansilla, Florencia Celeste; Quintana, Maria Eugenia; Cardoso, Nancy; Capozzo, Alejandra (2016)We demonstrated recently that immunization with recombinant Neospora caninum profilin (rNcPRO) induces limited protection and a regulatory T-cell response in mice. The aim of this study was to evaluate the immune response ... -
Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice
Mansilla, Florencia Celeste; Quintana, Maria Eugenia; Langellotti, Cecilia Ana; Wilda, Maximiliano; Martinez, Andrea; Fonzo, Adriana; Moore, Prando Dadin; Cardoso, Nancy; Capozzo, Alejandra (2016)Profilins are actin-binding proteins that regulate the polymerization of actin filaments. In apicomplexan parasites, they are essential for invasion. Profilins also trigger the immune response of the host by activating ... -
In-vivo activity of IFN-λ and IFN-α against bovine-viral-diarrhea virus in a mouse model
Quintana, Maria Eugenia; Barone, Lucas Jose; Trotta, Myrian Vanesa; Turco, Cecilia Soledad; Mansilla, Florencia Celeste; Capozzo, Alejandra; Cardoso, Nancy (Frontiers Media, 2020-02)Bovine-viral-diarrhea virus (BVDV) can cause significant economic losses in livestock. The disease is controlled with vaccination and bovines are susceptible until vaccine immunity develops and may remain vulnerable if a ... -
Interferon lambda protects cattle against bovine viral diarrhea virus infection
Quintana, Maria Eugenia; Cardoso, Nancy; Pereyra, Walter Rodrigo; Barone, Lucas Jose; Barrionuevo, Florencia Mariel; Mansilla, Florencia Celeste; Turco, Cecilia Soledad; Capozzo, Alejandra (Elsevier, 2020-12)Interferon lambda (IFN-λ) plays an important role in inducing an antiviral state in mucosal surfaces and has been used as an effective biotherapeutic against several viral diseases. Here we performed a proof of concept ... -
Structure-based drug design for envelope protein E2 uncovers a new class of bovine viral diarrhea inhibitors that block virus entry
Pascual, María José; Merwaiss, Fernando; Leal, Emilse Soledad; Quintana, Maria Eugenia; Capozzo, Alejandra Victoria; Cavasotto, Claudio Norberto; Bollini, Mariela; Alvarez, Diego Ezequiel (Elsevier, 2018-01)Antiviral targeting of virus envelope proteins is an effective strategy for therapeutic intervention of viral infections. Here, we took a computer-guided approach with the aim of identifying new antivirals against the ...