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Mostrando ítems 1-17 de 17
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An efficient vaccine against bovine leukemia virus
Gutierrez, Gerónimo; Rodríguez, Sabrina M.; Vilor, Agustín; Gillet, Nicolas A.; DeBrogniez, Alix; Trono, Karina Gabriela; Willems, Luc (BioMed Central, 2015)Previous attempts to produce a vaccine against BLV faced problems of efficacy (i.e. only a fraction of animals were protected), persistence (i.e. rapid decrease of immune protection), cost (e.g. production of purified ... -
Bovine leukemia virus infection in neonatal calves. Risk factors and control measures
Ruiz, Vanesa; Porta, Natalia Gabriela; Lomonaco, Marina; Trono, Karina Gabriela; Alvarez, Irene (Frontiers Media, 2018-10)Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL). Although efficient eradication programs have been successfully implemented in most European countries and Oceania, BLV infection rates ... -
Bovine leukemia virus small noncoding RNAs are functional elements that regulate replication and contribute to oncogenesis in vivo
Gillet, Nicolas A.; Hamaidia, Malik; Brogniez, Alix de; Gutierrez, Gerónimo; Renotte, Nathalie; Reichert, Michal; Trono, Karina Gabriela; Willems, Luc (2016-04)Retroviruses are not expected to encode miRNAs because of the potential problem of self-cleavage of their genomic RNAs. This assumption has recently been challenged by experiments showing that bovine leukemia virus (BLV) ... -
Characterization of colostrum from dams of BLV endemic dairy herds
Gutierrez, Gerónimo; Lomonaco, Marina; Alvarez, Irene; Fernandez, Fernando; Trono, Karina Gabriela (Elsevier, 2015-06)Bovine Leukemia Virus (BLV) is endemic in Argentina, where the individual prevalence is higher than 80% in dairy farms. The aim of this work was to find preliminary evidence to know if the high level of infection of the ... -
Detection of bovine leukemia virus RNA in blood samples of naturally infected dairy cattle
Alvarez, Irene; Porta, Natalia Gabriela; Trono, Karina Gabriela (MDPI, 2019-09)The viral expression in vivo, in bovine leukemia virus (BLV)-infected cattle, is considered to be restricted to extremely low levels, and the mitosis of infected B lymphocytes is regarded as the main mode of virus persistence ... -
Dynamics of perinatal bovine leukemia virus infection
Gutierrez, Gerónimo; Alvarez, Irene; Merlini, Ramiro; Rondelli, Flavia; Trono, Karina Gabriela (BioMed Central, 2014)Bovine leukemia virus (BLV) is highly endemic in many countries, including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important ... -
The efficacy of ELISA commercial kits for the screening of equine infectious anemia virus infection = Eficacia de ensayos de ELISA comerciales para el screening de infección por el virus de la anemia infecciosa equina
Alvarez, Irene; Cipolini, Fabiana; Wigdorovitz, Andres; Trono, Karina Gabriela; Barrandeguy, Maria Edith (Elsevier España, 2015-03)The most used and reliable indicator of equine infectious anemia virus (EIAV) infection is the detection of its specific antibodies in horse serum. In the present study, the performance of two commercial ELISA tests for ... -
Efficacy of the spray-drying treatment to inactivate the bovine leukemia virus in bovine colostrum
Lomonaco, Marina; Sowul, Mariana; Gutierrez, Gerónimo; Malacari, Darío Amilcar; Alvarez, Irene; Porta, Natalia Gabriela; Zabal, Osvaldo Alfredo; Trono, Karina Gabriela (Elsevier, 2020-07)Previous studies have shown the presence of bovine leukemia virus (BLV) in colostrum and milk of naturally infected cows. The relationship between virus or provirus and specific antibodies in these secretions is particular ... -
Evaluation of total white blood cell count as a marker for proviral load of bovine leukemia virus in dairy cattle from herds with a high seroprevalence of antibodies against bovine leukemia virus
Alvarez, Irene; Gutierrez, Gerónimo; Gammella, Mariela; Martínez, Cecilia; Politzki, Romina Paula; González, Cintia Beatríz; Caviglia, Luciana; Carignano, Hugo; Fondevila, Norberto Antonio; Poli, Mario Andres; Trono, Karina Gabriela (2013-05)Objective—To determine the reference interval for WBC counts in Holstein dairy cows from herds with high seroprevalence for anti–bovine leukemia virus (BLV) antibodies, analyze the correlation of total WBC counts and blood ... -
Experimental infection of sheep with bovine leukemia virus (BLV): minimum dose of BLV-FLK cells and cell-free BLV and neutralization activity of natural antibodies = Infección experimental en ovinos con el virus de leucosis bovina: dosis mínima de células BLV-FLK y virus libre de células, y actividad neutralizante de anticuerpos naturales
Porta, Natalia Gabriela; Alvarez, Irene; Suarez Archilla, Guillermo Alejandro; Ruiz, Vanesa; Abdala, Alejandro Ariel; Trono, Karina Gabriela (Elsevier España, 2019-12)Bovine leukemia virus (BLV) is an important cattle pathogen that causes major economic losses worldwide, especially in dairy farms. The use of animal models provides valuable insight into the pathogenesis of viral infections. ... -
Expression-based analysis of genes related to single nucleotide polymorphism hits associated with bovine leukemia virus proviral load in Argentinean dairy cattle
Petersen, Marcos Iván; Carignano, Hugo Adrian; Suarez Archilla, Guillermo; Caffaro, María Eugenia; Alvarez, Irene; Miretti, Marcos Mateo; Trono, Karina Gabriela (Elsevier, 2021-02)In dairy cattle infected with bovine leukemia virus (BLV), the proviral load (PVL) level is directly related to the viral transmission from infected animals to their healthy herdmates. Two contrasting phenotypic groups can ... -
Influencia de las condiciones de incubación en la detección de anticuerpos contra el Virus de la Leucosis bovina por ELISA = Influence of the incubation conditions on the detection of antibodies to bovine leukemia virus by ELISA
Lomonaco, Marina; Martinez, Cecilia; Alvarez, Irene; Gutierrez, Gerónimo; Politzki, Romina Paula; Trono, Karina Gabriela (Sociedad de Medicina Veterinaria, 2013-05)En este trabajo se modificaron las condiciones de incubación del ensayo de ELISAp24 que detecta anticuerpos contra el Virus de la Leucosis bovina, con el propósito de evaluar si se reduce el número de resultados falsos y ... -
Recent advances in BLV research
Barez, Pierre-Yves; De Brogniez, Alix; Carpentier, Alexandre; Gazon, Hélène; Gillet, Nicolas; Gutierrez, Gerónimo; Hamaidia, Malik; Jacques, Jean-Rock; Perike, Srikanth; Sriramareddy, Sathya Neelature; Renotte, Nathalie; Staumont, Bernard; Reichert, Michal; Trono, Karina Gabriela; Willems, Luc (MDPI, 2015-11)Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and ... -
Seroprevalence and risk factors associated with bovine Leukemia virus infection in argentine beef cattle
Porta, Natalia Gabriela; Suarez Archilla, Guillermo; Miotti, Camila; Molineri, Ana Ines; Alvarez, Irene; Trono, Karina Gabriela; Signorini Porchiett, Marcelo Lisandro; Ruiz, Vanesa (Elsevier, 2023-11)Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, an endemic disease in dairy cattle of Argentina. However, little is known about the seroprevalence of BLV in beef cattle. In this study, we ... -
Short communication: Relationship between the level of bovine leukemia virus antibody and provirus in blood and milk of cows from a naturally infected herd
Jaworski, Juan Pablo; Porta, Natalia Gabriela; Gutierrez, Gerónimo; Politzki, Romina Paula; Alvarez, Irene; Galarza, Roxana Ivon; Abdala, Alejandro Ariel; Calvinho, Luis Fernando; Trono, Karina Gabriela (2016)We explored the relationship between the level of bovine leukemia virus antibodies and provirus load during natural infection. For that purpose, a set of 50 blood and milk paired samples were analyzed for the presence of ... -
Spontaneous virus reactivation in cattle chronically infected with bovine leukemia virus
Jaworski, Juan Pablo; Petersen, Marcos Iván; Carignano, Hugo; Trono, Karina Gabriela (BioMed Central, 2019)Background: The absence of virus expression during the chronic stage of bovine leukemia virus (BLV) infection and its reactivation upon ex vivo culture has become a long-lived Dogma. During the chronic stage of BLV ... -
Vaccination against δ-retroviruses : the bovine leukemia virus paradigm
Gutierrez, Gerónimo; Rodriguez, Sabrina M.; de Brogniez, Alix; Gillet, Nicolas A.; Golime, Ramarao; Burny, Arsene; Jaworski, Juan Pablo; Alvarez, Irene; Vagnoni, Lucas Emilio; Trono, Karina Gabriela; Willems, Luc (2014-06)Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical ...