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Temas

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    • Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles 

      Bigi, María Mercedes; Vazquez, Cristina Lourdes; Castelão, Ana Beatriz C.; Garcia, Elizabeth Andrea; Cataldi, Angel Adrian; Jackson, Mary; McNeil, Michael; Soria, Marcelo Abel; Zumarraga, Martin Jose; Cabruja, Matias; Gago, Gabriela; Blanco, Federico Carlos; Nishibe, Christiane; Almeida Junior, Nalvo Franco de; Araujo, Flabio Ribeiro de; Bigi, Fabiana (Elsevier, 2019-12)
      Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic ...

    • BoLA-DRB3 exon2 polymorphisms among tuberculous cattle: Nucleotide and functional variability and their association with bovine tuberculosis pathology 

      Eirin, Maria Emilia; Carignano, Hugo Adrian; Shimizu, Ernesto; Pando, Maria de los Angeles; Zumarraga, Martin Jose; Magnano, Gabriel; Macías, Analía; Garbaccio, Sergio Gabriel; Huertas, Pablo Sebastian; Morsella, Claudia Graciela; Ferrara Muñiz, Ximena; Cataldi, Angel Adrian; Paolicchi, Fernando; Poli, Mario Andres (Elsevier, 2020-06)
      Bovine tuberculosis (bTB) is caused by Mycobacterium bovis and disseminated worldwide. In Argentina, the highest prevalence occurs in dairy areas. BoLA DRB3.2 is related to the adaptive immunity in mycobacterial infections. ...

    • Detection of Mycobacterium bovis in Bovine and Bubaline tissues using Nested-PCR for TbD1 

      Araújo, Cristina Pires de; Osório, Ana Luiza Alves Rosa; Jorge, Klaudia dos Santos Goncalves; Ramos, Carlos Alberto N.; Filho, Antonio Francisco S.; Vidal, Carlos Eugênio Soto; Roxo, Eliana; Nishibe, Christiane; Almeida Junior, Nalvo Franco de; Júnior, Antônio A. F.; Silva, Marcio Roberto; Neto, Jose Diomedes Barbosa; Cerqueira, Valíria Duarte; Zumarraga, Martin Jose; Araujo, Flabio Ribeiro de (PLOS, 2014-03)
      In the present study, a nested-PCR system, targeting the TbD1 region, involving the performance of conventional PCR followed by real-time PCR, was developed to detect Mycobacterium bovis in bovine/bubaline tissue homogenates. ...

    • Detection of Mycobacterium bovis–infected dairy herds using PCR in bulk tank milk samples 

      Zumarraga, Martin Jose; Soutullo, Adriana; Garcia, Maria Ines; Marini, M. Rocío; Abdala, Alejandro Ariel; Tarabla, Hector Dante; Echaide, Susana T. de; Lopez, Marcela; Zervini, Elsa; Canal, Ana María; Cataldi, Angel Adrian (Mary Ann Liebert Inc., 2012-02)
      Bovine tuberculosis (bTB) is a chronic and zoonotic disease due to Mycobacterium bovis. The tuberculosis eradication campaign carried out in Argentina has considerably improved the health situation of the herds. Here we ...

    • Development and diagnostic validation of an ELISA based on an antigenic mixture for the detection of bovine tuberculosis 

      Griffa, Natanael; Moyano, Roberto Damián; Canal, Ana María; Traveria, Gabriel Eduardo; Santangelo, María De La Paz; Alonso, Maria Natalia; Romano, Maria Isabel (Elsevier, 2020-02)
      Programs for the eradication of bovine tuberculosis (bTB) focus on the tuberculin skin test (TST) and slaughter of reactor cattle. However, the disease remains an animal health concern in several countries and improving ...

    • Development of a lateral flow immunochromatography test for the rapid detection of bovine tuberculosis 

      Alonso, Maria Natalia; Griffa, Natanael; Moyano, Roberto Damián; Mon, Maria Laura; Colombatti Olivieri, Maria Alejandra; Barandiaran, Soledad; Martinez Vivot, Marcela; Fiorini, Gonzalo; Canal, Ana María; Santangelo, María De La Paz; Singh, Mahavir G.; Romano, Maria Isabel (Elsevier, 2021-04)
      Detection of specific antibodies would be a useful test strategy for bovine tuberculosis (bTB) as a complement to the single skin test. We developed a lateral flow immunochromatography (LFIC) test for rapid bTB detection ...

    • Epidemiology of Pig Tuberculosis in Argentina 

      Barandiaran, Soledad; Marfil, Maria Jimena; Capobianco, Guillermo; Perez Aguirreburualde, María Sol; Zumarraga, Martin Jose; Eirin, Maria Emilia; Cuerda, Maria Ximena; Winter, Marina; Martinez Vivot, Marcela; Pérez, Andrés Maximiliano; La Sala, Luciano Francisco (Frontiers Editorial, 2021-07)
      Bovine tuberculosis (bTB) is a disease caused mainly by the Mycobacterium bovis and that is endemic to livestock populations in most Latin American countries. Traditionally, bTB control programs are costly and targeted to ...

    • ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis 

      Blanco, Federico Carlos; Soria, Marcelo Abel; Klepp, Laura Ines; Bigi, Fabiana (Karger, 2017-12)
      Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses ...

    • FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis 

      Mondino, Sonia; Vazquez, Cristina Lourdes; Cabruja, Matias; Sala, Claudia; Cazenave-Gassiot, Amaury; Blanco, Federico Carlos; Wenk, Markus R.; Bigi, Fabiana; Cole, Stewart T.; Gramajo, Hugo; Gago, Gabriela (Frontiers Media, 2020-10)
      Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is the world’s leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition ...

    • First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn 

      Echeverria, Gustavo; Rueda, Veronica; Espinoza, Wilson; Rosero, Carlos; Zumarraga, Martin Jose; Waard, Jacobus H. de (MDPI, 2023-04)
      Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that ...

    • Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts 

      Morcillo, Nora; Imperiale, Belen Rocio; Di Giulio, Angela Beatríz; Zumarraga, Martin Jose; Takif, Howard; Cataldi, Angel Adrian (Elsevier, 2014-12)
      There has been an on-going debate on whether the development of drug resistance in Mycobacterium tuberculosis reduces its relative fitness and its ability to cause disease. The aim of this study was to explore this ...

    • La genómica de las micobacterias 

      Viale, Mariana; Zumarraga, Martin Jose; Araujo, Flabio Ribeiro de; Zarraga, Ana Maria; Cataldi, Angel Adrian; Romano, Maria Isabel; Bigi, Fabiana (Office International des Epizooties, 2016)
      Las especies Mycobacterium bovis y Mycobacterium avium subsp. paratuberculosis son los agentes causales de la tuberculosis y la paratuberculosis en animales, respectivamente. Además, ambas micobacterias, pero fundamentalmente ...

    • Identification and evaluation of new Mycobacterium bovis antigens in the in vitro interferon gamma release assay for bovine tuberculosis diagnosis 

      Eirin, Maria Emilia; Macías, Analía; Magnano, Gabriel; Morsella, Claudia Graciela; Mendez, Laura Luján; Blanco, Federico Carlos; Bianco, María Veronica; Severina, Walter; Alito, Alicia Elsa; Pando, Maria de los Angeles; Singh, Mahavir G.; Spallek, Ralph; Paolicchi, Fernando; Bigi, Fabiana; Cataldi, Angel Adrian (Elsevier, 2015-12)
      Bovine tuberculosis (bTB) is a common zoonotic disease, caused by Mycobacterium bovis (M. bovis), responsible for significant economic losses worldwide. Its diagnosis is based on the detection of cell mediated immunity ...

    • Identification of bovine tuberculosis biomarkers to detect tuberculin skin test and IFNγ release assay false negative cattle 

      Klepp, Laura Ines; Eirin, Maria Emilia; Garbaccio, Sergio Gabriel; Soria, Marcelo Abel; Bigi, Fabiana; Blanco, Federico Carlos (Elsevier, 2019-02)
      Bovine tuberculosis (bTB) is an important animal and zoonotic disease, which causes severe economic losses. The main focus of this study was to assess the predictive power of previously identified biomarkers of bTB in ...

    • IL-12 DNA Displays efficient adjuvant effects improving immunogenicity of Ag85A in DNA prime/MVA boost immunizations 

      Morelli, María Paula; Del Medico Zajac, Maria Paula; Pellegrini, Joaquín Miguel; Amiano, Nicolás Oscar; Tateosian, Nancy Liliana; Calamante, Gabriela; Gherardi, Maria Magdalena; García, Verónica Edith (Frontiers Media, 2020-09)
      Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, ...

    • Matrix assisted laser desorption ionization-time-of-flight mass spectrometry identification of mycobacterium bovis in bovinae 

      Bacanelli, Gisele; Olarte, Larissa C.; Silva, Marcio Roberto; Rodrigues, Rudielle A.; Carneiro, Paulo A. M.; Kannene, John B.; Pasquatti, Taynara N.; Takatani, Haruo; Zumarraga, Martin Jose; Etges, Rodrigo N.; Araujo, Flabio Ribeiro de; Verbisck, Newton V. (The Japanese Society of Veterinary Science, 2019-10)
      In this study, Matrix Assisted Laser Desorption Ionization-Time-of-Flight (MALDI-TOF) mass spectrometry was used to identify Mycobacterium bovis from cattle and buffalo tissue isolates from the North and South regions of ...

    • Molecular characterization of Mycobacterium bovis infection in cattle and buffalo in Amazon Region, Brazil 

      Carneiro, Paulo A.M.; Pasquatti, Taynara N.; Takatani, Haruo; Zumarraga, Martin Jose; Marfil, Maria Jimena; Barnard, Christian; Fitzgerald, Scott D.; Abramovitch, Robert B.; Araujo, Flabio Ribeiro de; Kaneene, John B. (Wiley, 2020-02)
      The aim of this study was to characterize Mycobacterium bovis from cattle and buffalo tissue samples, from two Brazilian states, and to analyse their genetic diversity by spoligotyping. Tissue samples from tuberculosis ...

    • Mycobacterioses in dogs and cats from Buenos Aires, Argentina 

      Barandiaran, Soledad; Martinez Vivot, Marcela; Falzoni, Elvira; Marfil, Maria Jimena; Perez Tort, Gabriela; Rovatti, Paula; Fernandez, Mónica; Iachini, Ricardo; Satek, Fernanda; Duchene, Adriana; Zumarraga, Martin Jose (Sage Publications, 2017-09)
      Mycobacterioses can produce nonspecific clinical signs in dogs and cats that make diagnosis difficult. Furthermore, the full characterization of mycobacterial agents is not always possible or practical. We characterized ...

    • Mycobacterium bovis Dmce2 double deletion mutant protects cattle against challenge with virulent M. bovis 

      Blanco, Federico Carlos; Bianco, María Veronica; Garbaccio, Sergio Gabriel; Meikle, Virginia; Gravisaco, María José; Montenegro, Valeria Noely; Alfonseca, Edgar; Singh, Mahavir G.; Barandiaran, Soledad; Canal, Ana María; Vagnoni, Lucas Emilio; Buddle, Bryce Malcom; Bigi, Fabiana; Cataldi, Angel Adrian (Elsevier, 2013-05)
      A Mycobacterium bovis strain deleted in mce2A and mce2B genes (M. bovis Δmce2) was tested as an experimental vaccine in cattle challenged with a virulent M. bovis strain. Three-and-a-half-month old calves (n = 5 to 6 per ...

    • Mycobacterium bovis infection in a horse with granulomatous enterocolitis 

      Sarradell, Javier E.; Alvarez, Julio; Biscia, Mariana; Zumarraga, Martin Jose; Wunschmann, Arno; Armien, Aníbal G.; Perez, Andrés M. (Sage Publications, 2015-03)
      A 2-year-old dappled Percheron horse had a wasting condition that did not respond to antibiotic treatments and ultimately resulted in death. Thickening of the wall of the large colon and enlargement of the mesenteric lymph ...