Browsing Artículos científicos by Subject 

Browsing Artículos científicos by Subject "Tuberculosis"

Now showing items 21-34 of 34

    • Mycobacterium bovis requires P27 (LprG) to arrest phagosome maturation and replicate within bovine macrophages 

      Vazquez, Cristina Lourdes; Bianco, María Veronica; Blanco, Federico Carlos; Forrellad, Marina Andrea; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (2017-03)
      Mycobacterium bovis causes tuberculosis in a wide variety of mammals, with strong tropism for cattle and eventually humans. P27, also called LprG, is among the proteins involved in the mechanisms of the virulence and ...

    • Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis 

      Cuerda, Maria Ximena; Colombatti Olivieri, Maria Alejandra; Gravisaco, María José; Marfil, Maria Jimena; Barandiaran, Soledad; Sevilla, Iker A.; Garrido, Joseba M.; Moyano, Roberto Damian; Zumarraga, Martin Jose; Romano, Maria Isabel; Juste, Ramón A.; Santangelo, María De La Paz (INIA (España), 2022-03)
      Aim of study: To demonstrate the virulence of a Mycobacterium bovis local pig isolate in order to contribute to a better understanding of the pathological and immunological consequences of M. bovis infection in previous ...

    • Patterns and processes of mycobacterium bovis evolution revealed by phylogenomic analyses 

      Patané, José S.L.; Martins Jr, Joaquim; Castelão, Ana Beatriz C.; Nishibe, Christiane; Montera, Luciana; Bigi, Fabiana; Zumarraga, Martin Jose; Cataldi, Angel Adrian; Fonseca Junior, Antônio; Roxo, Eliana; Osório, Ana Luiza Alves Rosa; Jorge, Klaudia dos Santos Goncalves; Thacker, Tyler C.; Almeida, Nalvo Franco; Araujo, Flabio Ribeiro de; Setubal, Joâo C. (Oxford University Press, 2017-03)
      Mycobacterium bovis is an important animal pathogen worldwide that parasitizes wild and domesticated vertebrate livestock as well as humans. A comparison of the five M. bovis complete genomes from the United Kingdom, South ...

    • Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis 

      Bos, Kirsten I.; Harkins, Kelly M.; Herbig, Alexander; Coscolla, Mireia; Weber, Nico; Comas, Iñaki; Forrest, Stephen A.; Bryant, Josephine M.; Harris, Simon R.; Schuenemann, Verena J.; Campbell, Tessa J.; Majander, Kerrtu; Wilbur, Alicia K.; Guichon, Ricardo A.; Steadman, Dawnie L. Wolfe; Cook, Della Collins; Niemann, Stefan; Behr, Marcel A.; Zumarraga, Martin Jose; Bastida, Ricardo; Huson, Daniel; Nieselt, Kay; Young, Douglas; Parkhill, Julian; Buikstra, Jane E.; Gagneux, Sebastien; Stone, Anne C.; Krause, Johannes (Springer Nature, 2014-08)
      Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible ...

    • Recent advances in non-specific immune memory against bovine tuberculosis 

      Blanco, Federico Carlos; Sabio Y Garcia, Julia Veronica; Bigi, Fabiana (Elsevier, 2021-04)
      Bovine tuberculosis is an important worldwide disease mainly related to cattle, although it also affects other mammals, including humans. In recent years, there have been considerable advances in the knowledge of the immune ...

    • Replication and transmission features of two experimental vaccine candidates against bovine tuberculosis subcutaneously administrated in a murine model 

      Ferrara Muñiz, Ximena; Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, Fabiana; Zumarraga, Martin Jose; Cataldi, Angel Adrian; Eirin, Maria Emilia (Elsevier, 2022-05)
      Cattle vaccination is an attractive approach in compliance with control and eradication programs against Bovine Tuberculosis (bTB). Today, there is no anti bTB vaccine licensed. Two vaccine candidates, MbΔmce2 and MbΔmce2-phoP ...

    • Role of PhoPR in the response to stress of Mycobacterium bovis 

      Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Klepp, Laura Ines; Pazos, Adriana Alejandra; McNeil, Michael; Jackson, Mary; Bigi, Fabiana (Elsevier, 2021-02)
      PhoP is part of the two-component PhoPR system that regulates the expression of virulence genes of Mycobacteria. The goal of this work was to elucidate the role of PhoP in the mechanism that Mycobacterium bovis, the causative ...

    • Rv2577 of Mycobacterium tuberculosis is a virulence factor with dual phosphatase and phosphodiesterase functions 

      Forrellad, Marina Andrea; Blanco, Federico Carlos; Marrero Diaz De Vill, Rubén; Vazquez, Cristina Lourdes; Yaneff, Agustín; Garcia, Elizabeth Andrea; Gutierrez, Maximiliano Gabriel; Durán, Rosario; Villarino, Andrea; Bigi, Fabiana (Frontiers Media, 2020-10)
      Tuberculosis, a lung disease caused by Mycobacterium tuberculosis (Mtb), is one of the ten leading causes of death worldwide affecting mainly developing countries. Mtb can persist and survive inside infected cells through ...

    • Spatial distribution of Mycobacterium bovis spoligotypes in cattle from the state of Minas Gerais, Brazil 

      Souza, Mariana Assunção de; Lopes, Thaís Aline Carolino; Silva, Brendhal Almeida; Bombonato, Nadia Grandi; Dib, Cristina Corsi; Marfil, Maria Jimena; Zumarraga, Martin Jose; Lima, Anna Monteiro Correia (Springer, 2022-07)
      Genotyping methods have led to a better understanding of the epidemiology of Mycobacterium bovis (M. bovis) infection, and its transmission dynamics, as well as the possible phylogenetic relationships between Mycobacterium ...

    • Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis 

      Forrellad, Marina Andrea; Bianco, María Veronica; Blanco, Federico Carlos; Nuñez, Javier; Klepp, Laura Ines; Vazquez, Cristina Lourdes; Santangelo, María De La Paz; Rocha, Rosana Valeria; Soria, Marcelo; Golby, Paul; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (BMC, 2013-09)
      Background: Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called ...

    • Surveillance and characterization of drug‑resistant mycobacterium tuberculosis isolated in a reference hospital from Argentina during 8 years’ period 

      Imperiale, Belen Rocio; Di Giulio, Angela Beatríz; Mancino, María Belén; Zumarraga, Martin Jose; Morcillo, Nora (Wolters Kluwer, 2019-09)
      Background: Argentina is considered a country with a middle tuberculosis (TB) incidence. However, according to the last national epidemiological report released in 2018, since 2013, the trends are steadily increasing. The ...

    • Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina 

      Barandiaran, Soledad; Pérez, Andrés M.; Gioffre, Andrea; Martinez Vivot, Marcela; Cataldi, Angel Adrian; Zumarraga, Martin Jose (Cambridge University Press, 2015-04)
      In Argentina little is known about the epidemiology of tuberculosis (TB) infection in swine. We characterized the epidemiological dynamics of Mycobacterium avium complex (MAC) infection in a swine population of Argentina ...

    • Tuberculosis vaccine candidates based on mycobacterial cell envelope components 

      Sarmiento, María E.; Alvarez, N.; Chin, K.L.; Bigi, Fabiana; Tirado Hernández, Yanely; García, M.A.; Anis, F.Z.; Norazmi, Mohd Nor; Acosta, Armando (Elsevier, 2019-03)
      Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). ...

    • Understanding the relationship between Mycobacterium bovis spoligotypes from cattle in Latin American Countries 

      Zumarraga, Martin Jose; Arriaga, Camila; Barandiaran, Soledad; Cobos-Marín, Laura; de Waard, Jacobus; Estrada-Garcia, Iris; Figueiredo, Telma; Figueroa, Alvaro; Gimenez, Francisco; Gomes, Harrison M.; Gonzalez-y-Merchand, Jorge A.; Macías, Analía; Milián-Suazo, Feliciano; Rodríguez, Cesar Alejandro Rosales; Santillán, Marco Antonio; Suffys, Philip Noel; Trangoni, Marcos David; Zarraga, Ana Maria; Cataldi, Angel Adrian (Elsevier, 2013-02)
      Spoligotyping is the most frequently used method for genotyping isolates of Mycobacterium bovis worldwide. In the current work, we compared spoligotypes from 1684 M. bovis isolates from Argentina (816), Brazil (412), Chile ...