Mostrar el registro sencillo del ítem

resumen

Resumen
Ticks transmit zoonotic pathogens worldwide. Nevertheless, very little information is available on their genome, transcriptome and proteome. Herein, we characterized the proteome of Amblyomma americanum adults and nymphs because of their role in pathogen transmission and compared the proteome of A. americanum, A. cajennense and A. variegatum adult ticks. We also used de novo sequencing proteomics data for the analysis of the phylogenetic relationships [ver mas...]
dc.contributor.authorVillar, Margarita
dc.contributor.authorPopara, Marina
dc.contributor.authorMangold, Atilio Jose
dc.contributor.authorFuente, José de la
dc.date.accessioned2018-08-10T11:48:28Z
dc.date.available2018-08-10T11:48:28Z
dc.date.issued2014-06-13
dc.identifier.issn1874-3919
dc.identifier.issn1876-7737
dc.identifier.otherhttps://doi.org/10.1016/j.jprot.2013.12.016
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1874391913006519
dc.identifier.urihttp://hdl.handle.net/20.500.12123/3039
dc.description.abstractTicks transmit zoonotic pathogens worldwide. Nevertheless, very little information is available on their genome, transcriptome and proteome. Herein, we characterized the proteome of Amblyomma americanum adults and nymphs because of their role in pathogen transmission and compared the proteome of A. americanum, A. cajennense and A. variegatum adult ticks. We also used de novo sequencing proteomics data for the analysis of the phylogenetic relationships between the three Amblyomma spp. in a proof of concept for phyloproteomics. The results showed that host and tick proteins involved in blood digestion, heme detoxification, development and innate immunity were differentially represented between adults and nymphs. Although these ticks were unfed, over-represented host proteins may supply nutrients during off-host periods. Tick proteins involved in tick attachment, feeding, heat shock response, protease inhibition and heme detoxification were differentially represented between Amblyomma spp., suggesting adaptation processes to biotic and abiotic factors. These results suggested that phyloproteomics might be a useful tool for the phylogenetic analysis of tick species in which sequence data is a limiting factor and demonstrate the possibilities of proteomics studies for the characterization of relevant tick vector species and provide new relevant information to understand the physiology, development and evolution of these tick species.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceJournal of Proteomics 105 : 204-216 (June 2014)es_AR
dc.subjectAmblyommaes_AR
dc.subjectVectoreses_AR
dc.subjectVectorseng
dc.subjectZoonosises_AR
dc.subjectZoonoseseng
dc.subjectHuéspedeses_AR
dc.subjectHostseng
dc.subject.otherGarrapatases_AR
dc.subject.otherProteómicaes_AR
dc.titleComparative proteomics for the characterization of the most relevant Amblyomma tick species as vectors of zoonotic pathogens worldwidees_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEEA Rafaelaes_AR
dc.description.filFil: Villar, Margarita. CSIC-UCLM-JCCM. Instituto de Investigación en Recursos Cinegéticos (IREC). SaBio; Españaes_AR
dc.description.filFil: Popara, Marina. CSIC-UCLM-JCCM. Instituto de Investigación en Recursos Cinegéticos (IREC). SaBio; Españaes_AR
dc.description.filFil: Mangold, Atilio Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentinaes_AR
dc.description.filFil: Fuente, José de la. CSIC-UCLM-JCCM. Instituto de Investigación en Recursos Cinegéticos (IREC). SaBio; España. Oklahoma State University. Center for Veterinary Health Sciences. Department of Veterinary Pathobiology; Estados Unidoses_AR
dc.subtypecientifico


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

common

Mostrar el registro sencillo del ítem