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Objectives: To obtain and assess stable cage‐like particles with low surface charge density, which can be prepared using a standardized, economic and scalable method.
Methods: To form these nanoparticles, the lipid composition and proportion as well the method were modified in relation to cage‐like particles previously described elsewhere. Bovine albumin was used to compare ISPA performance with that of other adjuvants in mice and to assess stability.
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dc.contributor.author | Bertona, Daiana | |
dc.contributor.author | Pujato, Nazarena | |
dc.contributor.author | Bontempi, Iván | |
dc.contributor.author | González, Verónica Doris Guadalupe | |
dc.contributor.author | Cabrera, Gabriel Gustavo | |
dc.contributor.author | Gugliotta, Luis Marcelino | |
dc.contributor.author | Hozbor, Daniela Flavia | |
dc.contributor.author | Nicastro, Alcides | |
dc.contributor.author | Calvinho, Luis Fernando | |
dc.contributor.author | Marcipar, Iván Sergio | |
dc.date.accessioned | 2018-07-18T14:14:26Z | |
dc.date.available | 2018-07-18T14:14:26Z | |
dc.date.issued | 2017-10 | |
dc.identifier.issn | 0022-3573 | |
dc.identifier.issn | 2042-7158 | |
dc.identifier.other | https://doi.org/10.1111/jphp.12768 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.12768 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/2813 | |
dc.description.abstract | Objectives: To obtain and assess stable cage‐like particles with low surface charge density, which can be prepared using a standardized, economic and scalable method. Methods: To form these nanoparticles, the lipid composition and proportion as well the method were modified in relation to cage‐like particles previously described elsewhere. Bovine albumin was used to compare ISPA performance with that of other adjuvants in mice and to assess stability. Adjuvant efficacy was analysed using a mouse model of Trypanosoma cruzi infection, which shows protection against an intracellular infection that needs a strong cellular response. Key findings: The new particles were better in terms of level, kinetics and profile of humoral responses than Freund Adjuvant, aluminium hydroxide and Montanide TM ISA 206; they also tended to improve ISCOMATRIX™ performance. Particle size and adjuvant performance were conserved during the 6‐month period assessed after preparation. In the model of Trypanosoma cruzi infection, mice immunized with ISPA and trans‐sialidase developed high protection. Conclusions: The obtained nanoparticles were stable and outperformed the other assessed adjuvants in joining together the capacity of most adjuvants to enhance the immune response against specific antigen, to reduce the number of doses, to homogenize the response between individuals and to reach a balanced TH1/TH2 response. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.source | Journal of Pharmacy and Pharmacology 69 (10) : 1293-1303 (October 2017) | es_AR |
dc.subject | Ganado Bovino | es_AR |
dc.subject | Cattle | eng |
dc.subject | Trypanosoma cruzi | es_AR |
dc.subject | Coadyuvantes | es_AR |
dc.subject | Adjuvants | eng |
dc.subject | Respuesta Inmunológica | es_AR |
dc.subject | Immune Response | eng |
dc.title | Development and assessment of a new cage‐like particle adjuvant | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.description.origen | EEA Rafaela | es_AR |
dc.description.fil | Fil: Bertona, Daiana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina | es_AR |
dc.description.fil | Fil: Pujato, Nazarena. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina | es_AR |
dc.description.fil | Fil: Bontempi, Iván. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina | es_AR |
dc.description.fil | Fil: González, Verónica Doris Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional del Litoral; Argentina | es_AR |
dc.description.fil | Fil: Cabrera, Gabriel Gustavo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Gugliotta, Luis Marcelino. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina | es_AR |
dc.description.fil | Fil: Hozbor, Daniela Flavia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular. Laboratorio VacSal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Nicastro, Alcides. LIPOMIZE SRL Santa Fe; Argentina | es_AR |
dc.description.fil | Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina | es_AR |
dc.description.fil | Fil: Marcipar, Ivan Sergio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.subtype | cientifico |
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