Mostrando ítems 1-20 de 21
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A safe and effective vaccine against bovine leukemia virus
(Frontiers Media, 2022-08)Previous attempts to develop a vaccine against bovine leukemia virus (BLV) have not been successful because of inadequate or short-lived stimulation of all immunity components. In this study, we designed an approach based ... -
Antibodies to SARS-CoV2 induced by vaccination and infection correlate with protection against the infection
(Elsevier, 2023-10)The COVID-19 pandemic remained worldwide for almost three years, but little is known about the dynamics of humoral immune response to the third dose over time and its protection from infection. Our aim was to assess the ... -
Assessment of the potential utility of different regions of Streptococcus uberis adhesion molecule (SUAM) for mastitis subunit vaccine development
(2017-04)Streptococcus uberis is one of the most prevalent pathogens causing clinical and subclinical mastitis worldwide. Among bacterial factors involved in intramammary infections caused by this organism, S. uberis adhesion ... -
BLV: lessons on vaccine development
(BMC, 2019-10-07)Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since ... -
Desarrollo de un inmunógeno prototípico para el control de mastitis bovinas causadas por Staphylococcus aureus
(Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 2012)Staphylococcus aureus es el patógeno más frecuentemente aislado de casos de mastitis bovina en Argentina y el mundo. Las particulares características de las infecciones intramamarias por S. aureus, han llevado a la búsqueda ... -
Diagnóstico y prevención de la neosporosis bovina. Desarrollo de técnicas serológicas y evaluación de inmunógenos basados en proteínas recombinantes
(Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, 2019)La neosporosis es una enfermedad abortígena, causada por el parásito protozoario Neospora caninum. No hay tratamientos o vacunas disponibles, el control se basa en el diagnóstico y las estrategias de manejo. Se desarrollaron ... -
Effects of the liposomal co-encapsulation of antigen and PO-CpG oligonucleotide on immune response in mice
(International Journal for Research, 2017-06)The development of novel vaccines requires the design of new adjuvants able to give long lasting immune responses. Our aim was to obtain cationic liposomes as adjuvants by an industry-suitable method, and evaluate them ... -
Efficacy of immunization with a recombinant S. aureus vaccine formulated with liposomes and ODN-CpG against natural S. aureus intramammary infections in heifers and cows
(Elsevier, 2022-07)The aims of the present study were to evaluate the ability of a subunit vaccine composed of recombinant molecules of α-toxin, β-toxin, FnBPA and ClfA, formulated with cationic liposomes and CpG-ODN, to confer protection ... -
Estudio de la diversidad genética en poblaciones de Babesia bigemina de diferentes regiones geográficas
(Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 2013)La babesiosis bovina es una enfermedad enzoótica causada por protozoarios Apicomplexa del género Babesia. En Argentina, esta enfermedad es provocada por B. bovis y B. bigemina, ambas trasmitidas por la garrapata Rhipicephalus ... -
Evaluación de la actividad inmunogénica de una vacuna para profilaxis de la anaplasmosis bovina
(Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste, 2019)El objetivo de este trabajo fue formular una vacuna criopreservada para la prevención de la anaplasmosis y evaluar su actividad inmunogénica. Se utilizó una vacuna monovalente de 2,5x107 eritrocitos bovinos infectados con ... -
Evaluation of the humoral immune response to a multicomponent recombinant vaccine against S. aureus in healthy pregnant heifers
(2018-05)Staphylococcus aureus is a worldwide pathogen that causes mastitis in dairy herds. Shortcomings in control programs have encouraged the development of vaccines against this pathogen. This study evaluated the vaccine candidate ... -
Functional role of antibodies generated in heifers through immunization with Staphylococcus aureus vaccines in invasion and phagocytosis assays
(2014-11)A successful Staphylococcus aureus vaccine should elicit a long-term antibody response that prevents establishment of the infection. The aim of the present study was to evaluate the functional role of antibodies raised ... -
Immune response and functional role of antibodies raised in heifers against a Staphylococcus aureus CP5 lysate and recombinant antigens vaccine formulated with Iscom Matrix adjuvant
(2014-12-15)Staphylococcus aureus is the most frequently isolated pathogen from bovine intramammary infections worldwide. Commercially available vaccines for mastitis control are composed either of S. aureus lysates or inactivated ... -
Immune response of heifers against a Staphylococcus aureus CP5 whole cell and lysate vaccine formulated with ISCOM Matrix adjuvant
(2014-02)Staphylococcus aureus is the most frequently isolated pathogen from bovine intramammary infections worldwide. Commercially available vaccines for mastitis control are composed either of S. aureus lysates or whole-cells ... -
Liposomal and CpG-ODN formulation elicits strong humoral immune responses to recombinant Staphylococcus aureus antigens in heifer calves
(Elsevier, 2019-05-01)Bovine mastitis caused by Staphylococcus aureus is a serious problem in dairy production and effective immunoprophylaxis is an unmet goal so far. The objective of this work was to assess the humoral immune response of ... -
Neospora caninum truncated recombinant proteins formulated with liposomes and CpG-ODNs triggered a humoral immune response in cattle after immunisation and challenge
(Elsevier, 2021-06)Abortions caused by Neospora caninum are a serious problem in cattle production and require effective immunoprophylaxis. The objective of this work was to assess the humoral immune response to four recombinant (r) N. caninum ... -
Preparation and characterization of a Staphylococcus aureus capsular polysaccharide-protein conjugate prepared by a low cost technique: a proof-of-concept study
(2015-01)Staphylococcus aureus is a worldwide distributed pathogen that produces several diseases in many species and is the major cause of mastitis in dairy cows. S. aureus capsular polysaccharide 5 (CP5) has been widely proposed ... -
Producción y evaluación de antígenos recombinantes para el diagnóstico serológico y la generación de vacunas para el control de la anaplasmosis bovina
(Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, 2020)La anaplasmosis bovina, causada por Anaplasma marginale (rickettsia intraeritrocítica transmitida por artrópodos hematófagos), es una enfermedad infecciosa de gran interés por las severas pérdidas económicas que ocasiona. ... -
Producción y evaluación de antígenos recombinantes para el diagnóstico serológico y la generación de vacunas para el control de la anaplasmosis bovina
(Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, 2020)En este trabajo se abordó la anaplasmosis de forma integral, desde el diagnóstico y la prevención. La evaluación serológica de la enfermedad se realiza por ELISA de competición (ELISAc), utilizando como antígeno a la ... -
A vaccine using Anaplasma marginale subdominant type IV secretion system recombinant proteins was not protective against a virulent challenge
(PLOS; National Center for Biotechnology Information, 2020-02)Anaplasma marginale is the most prevalent tick-borne livestock pathogen with worldwide distribution. Bovine anaplasmosis is a significant threat to cattle industry. Anaplasmosis outbreaks in endemic areas are prevented via ...