Mostrar el registro sencillo del ítem

resumen

Resumen
The aim of this work is to present a case study where the failure of IVM 3.15 % and DRM 1 % to prevent natural infestations of C. hominivorax larvae in Argentina is investigated based on field efficacy tests and a pharmacokinetic and pharmacodynamic analysis. Thirty male crossbred Braford calves were randomly assigned to three experimental groups (n = 10), the IVM 3.15 % group (subcutaneously at 630 µg/kg), the DRM 1 % group (subcutaneously at 200 µg/kg) [ver mas...]
dc.contributor.authorMuchiut, Sebastian
dc.contributor.authorMiró, Maria Victoria
dc.contributor.authorAnziani, Oscar
dc.contributor.authorNava, Santiago
dc.contributor.authorLifschitz, Adrian
dc.date.accessioned2025-02-05T11:47:06Z
dc.date.available2025-02-05T11:47:06Z
dc.date.issued2025-02
dc.identifier.issn0304-4017
dc.identifier.otherhttps://doi.org/10.1016/j.vetpar.2024.110384
dc.identifier.urihttp://hdl.handle.net/20.500.12123/21132
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0304401724002735
dc.description.abstractThe aim of this work is to present a case study where the failure of IVM 3.15 % and DRM 1 % to prevent natural infestations of C. hominivorax larvae in Argentina is investigated based on field efficacy tests and a pharmacokinetic and pharmacodynamic analysis. Thirty male crossbred Braford calves were randomly assigned to three experimental groups (n = 10), the IVM 3.15 % group (subcutaneously at 630 µg/kg), the DRM 1 % group (subcutaneously at 200 µg/kg) and the control group (saline solution subcutaneously). All treatments were performed at the time of castration surgery through a scrotal incision, and the wounds were exposed to natural infestations of C. hominivorax. Wound inspections were carried out on days 3, 6, and 13 post-treatments. Jugular blood samples were taken from experimental animals at 3- and 6-days post-treatment. In presence of C. hominivorax larvae, samples of both the larvae and wound secretions were collected in plastic vials on days 3 and 6 to measure concentrations of both drugs by high-performance liquid chromatography. On day 3 post-treatment, active myiasis was observed in 9 animals from the control group, 5 from the IVM 3.15 % group, and 6 from the DRM 1 % group. On day 6 post-treatment, 5 and 3 new myiasis were detected in the IVM 3.15 % and DRM 1 % group, respectively. No larvae were observed in the wounds on day 13 post-treatment. Interestingly, DRM concentrations tended to be higher in larvae compared to IVM on day 3 post-treatment (p = 0.051), and IVM plasma concentrations tended to be higher than those measured for DRM on day 6 (p = 0.087). There was a very strong correlation between DRM and IVM concentrations in plasma and wound secretions and larvae. The uptake of DRM from wound secretions to larvae was 83 % greater than that of IVM (p = 0.03). The results of this trial suggest the presence of C. hominivorax resistance to DRM and highlight concern about the lack of effectiveness of IVM 3.15 % in preventing C. hominivorax infestations.eng
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Técnica (ANPCyT) (PICT 2020-00127)es_AR
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.relationinfo:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y laes_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/es_AR
dc.sourceVeterinary Parasitology 334 : 110384 (2025)es_AR
dc.subjectDisease Controleng
dc.subjectControl de Enfermedadeses_AR
dc.subjectIvermectineng
dc.subjectIvermectinaes_AR
dc.subjectMyiasiseng
dc.subjectMiasises_AR
dc.subjectCochliomyia hominivoraxeng
dc.subject.otherNew world screwwormeng
dc.subject.otherGusano barrenador del nuevo mundoes_AR
dc.subject.otherMacrocyclic lactoneseng
dc.subject.otherLactonas macrocíclicases_AR
dc.subject.otherPreventive efficacyeng
dc.subject.otherEficacia preventivaes_AR
dc.subject.otherDoramectineng
dc.subject.otherDoramectinaes_AR
dc.titleFailure of doramectin and ivermectin in preventing Cochliomyia hominivorax myiasis in a subtropical region: A pharmacokinetic-pharmacodynamic studyes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)es_AR
dc.description.origenEEA Rafaelaes_AR
dc.description.filFil: Muchiut, Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentinaes_AR
dc.description.filFil: Muchiut, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigación de la Cadena Láctea (IDICAL); Argentinaes_AR
dc.description.filFil: Miró, Maria Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentinaes_AR
dc.description.filFil: Miró, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentinaes_AR
dc.description.filFil: Anziani, Oscar Sergio. Universidad Católica de Córdoba (UCC). Facultad Ciencias Agropecuarias; Argentinaes_AR
dc.description.filFil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentinaes_AR
dc.description.filFil: Nava, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigación de la Cadena Láctea (IDICAL); Argentinaes_AR
dc.description.filFil: Lifschitz, Adrian. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentinaes_AR
dc.description.filFil: Lifschitz, Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentinaes_AR
dc.subtypecientifico


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

common

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess
Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess