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The aim of this work is to present a case study where the failure of IVM 3.15 % and DRM 1 % to prevent natural infestations of C. hominivorax larvae in Argentina is investigated based on field efficacy tests and a pharmacokinetic and pharmacodynamic analysis. Thirty male crossbred Braford calves were randomly assigned to three experimental groups (n = 10), the IVM 3.15 % group (subcutaneously at 630 µg/kg), the DRM 1 % group (subcutaneously at 200 µg/kg)
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dc.contributor.author | Muchiut, Sebastian | |
dc.contributor.author | Miró, Maria Victoria | |
dc.contributor.author | Anziani, Oscar | |
dc.contributor.author | Nava, Santiago | |
dc.contributor.author | Lifschitz, Adrian | |
dc.date.accessioned | 2025-02-05T11:47:06Z | |
dc.date.available | 2025-02-05T11:47:06Z | |
dc.date.issued | 2025-02 | |
dc.identifier.issn | 0304-4017 | |
dc.identifier.other | https://doi.org/10.1016/j.vetpar.2024.110384 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/21132 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0304401724002735 | |
dc.description.abstract | The aim of this work is to present a case study where the failure of IVM 3.15 % and DRM 1 % to prevent natural infestations of C. hominivorax larvae in Argentina is investigated based on field efficacy tests and a pharmacokinetic and pharmacodynamic analysis. Thirty male crossbred Braford calves were randomly assigned to three experimental groups (n = 10), the IVM 3.15 % group (subcutaneously at 630 µg/kg), the DRM 1 % group (subcutaneously at 200 µg/kg) and the control group (saline solution subcutaneously). All treatments were performed at the time of castration surgery through a scrotal incision, and the wounds were exposed to natural infestations of C. hominivorax. Wound inspections were carried out on days 3, 6, and 13 post-treatments. Jugular blood samples were taken from experimental animals at 3- and 6-days post-treatment. In presence of C. hominivorax larvae, samples of both the larvae and wound secretions were collected in plastic vials on days 3 and 6 to measure concentrations of both drugs by high-performance liquid chromatography. On day 3 post-treatment, active myiasis was observed in 9 animals from the control group, 5 from the IVM 3.15 % group, and 6 from the DRM 1 % group. On day 6 post-treatment, 5 and 3 new myiasis were detected in the IVM 3.15 % and DRM 1 % group, respectively. No larvae were observed in the wounds on day 13 post-treatment. Interestingly, DRM concentrations tended to be higher in larvae compared to IVM on day 3 post-treatment (p = 0.051), and IVM plasma concentrations tended to be higher than those measured for DRM on day 6 (p = 0.087). There was a very strong correlation between DRM and IVM concentrations in plasma and wound secretions and larvae. The uptake of DRM from wound secretions to larvae was 83 % greater than that of IVM (p = 0.03). The results of this trial suggest the presence of C. hominivorax resistance to DRM and highlight concern about the lack of effectiveness of IVM 3.15 % in preventing C. hominivorax infestations. | eng |
dc.description.sponsorship | Agencia Nacional de Promoción Científica y Técnica (ANPCyT) (PICT 2020-00127) | es_AR |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Elsevier | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y la | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | Veterinary Parasitology 334 : 110384 (2025) | es_AR |
dc.subject | Disease Control | eng |
dc.subject | Control de Enfermedades | es_AR |
dc.subject | Ivermectin | eng |
dc.subject | Ivermectina | es_AR |
dc.subject | Myiasis | eng |
dc.subject | Miasis | es_AR |
dc.subject | Cochliomyia hominivorax | eng |
dc.subject.other | New world screwworm | eng |
dc.subject.other | Gusano barrenador del nuevo mundo | es_AR |
dc.subject.other | Macrocyclic lactones | eng |
dc.subject.other | Lactonas macrocíclicas | es_AR |
dc.subject.other | Preventive efficacy | eng |
dc.subject.other | Eficacia preventiva | es_AR |
dc.subject.other | Doramectin | eng |
dc.subject.other | Doramectina | es_AR |
dc.title | Failure of doramectin and ivermectin in preventing Cochliomyia hominivorax myiasis in a subtropical region: A pharmacokinetic-pharmacodynamic study | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | EEA Rafaela | es_AR |
dc.description.fil | Fil: Muchiut, Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina | es_AR |
dc.description.fil | Fil: Muchiut, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina | es_AR |
dc.description.fil | Fil: Miró, Maria Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina | es_AR |
dc.description.fil | Fil: Miró, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina | es_AR |
dc.description.fil | Fil: Anziani, Oscar Sergio. Universidad Católica de Córdoba (UCC). Facultad Ciencias Agropecuarias; Argentina | es_AR |
dc.description.fil | Fil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina | es_AR |
dc.description.fil | Fil: Nava, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina | es_AR |
dc.description.fil | Fil: Lifschitz, Adrian. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina | es_AR |
dc.description.fil | Fil: Lifschitz, Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina | es_AR |
dc.subtype | cientifico |
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