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Cathelicidin are innate antimicrobial peptides with broad immunomodulatory functions; however, their role in regulating intestinal defenses is not well characterized. This study aimed to investigate the role of cathelicidin modulating expression of Toll-like receptors (TLRs) 4 and 9 in colonic epithelium in response to bacterial patterns. We demonstrated herein that intestinal epithelial cells, when primed by bacterial lipopolysaccharide (LPS), responded
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dc.contributor.author | Marín, Maia Solange | |
dc.contributor.author | Holani, Ravi | |
dc.contributor.author | Shah, Chaitanya B. | |
dc.contributor.author | Odeon, Anselmo Carlos | |
dc.contributor.author | Cobo, Eduardo Rubén | |
dc.date.accessioned | 2018-03-13T17:16:25Z | |
dc.date.available | 2018-03-13T17:16:25Z | |
dc.date.issued | 2017-11 | |
dc.identifier.issn | 0161-5890 | |
dc.identifier.other | https://doi.org/10.1016/j.molimm.2017.09.011 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/2018 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0161589017305102?via%3Dihub#! | |
dc.description.abstract | Cathelicidin are innate antimicrobial peptides with broad immunomodulatory functions; however, their role in regulating intestinal defenses is not well characterized. This study aimed to investigate the role of cathelicidin modulating expression of Toll-like receptors (TLRs) 4 and 9 in colonic epithelium in response to bacterial patterns. We demonstrated herein that intestinal epithelial cells, when primed by bacterial lipopolysaccharide (LPS), responded to cathelicidin by increased transcription and protein synthesis of TLR4. This cathelicidin-induced response required the interaction of LPS-TLR4 and activation of MAPK signalling pathways. However, cathelicidin blocked TLR9 responses induced by TLR9 ligand CpG oligodeoxynucleotide (CpG ODN) in these colonic epithelial cells. Modulations of TLRs triggered by cathelicidin in intestinal epithelium occurred mainly in the apical compartment of intestinal cells. Activation of TLR4 by ligands in combination with cathelicidin promoted CXCL8 chemokine secretion and epithelial antimicrobial defenses against Escherichia coli. We concluded that cathelicidin selectively modulated synthesis of TLR4 and 9 in intestinal epithelium, but only when cells were exposed to virulence factors, mostly from apical surfaces. Enhanced TLR4 expression promoted by cathelicidin in intestinal epithelium may be crucial for controlling enteric infectious diseases. | eng |
dc.format | application/pdf | eng |
dc.language.iso | eng | |
dc.rights | info:eu-repo/semantics/restrictedAccess | eng |
dc.source | Molecular immunology 91 : 249-258. (November 2017) | eng |
dc.subject | Enfermedades de los Animales | es_AR |
dc.subject | Animal Diseases | eng |
dc.subject | Encefalitis | es_AR |
dc.subject | Encephalitis | eng |
dc.subject | Antimicrobianos | es_AR |
dc.subject | Antimicrobials | eng |
dc.subject | Escherichia coli | es_AR |
dc.title | Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium | eng |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/publishedVersion | eng |
dc.description.origen | EEA Balcarce | es_AR |
dc.description.fil | Fil: Marin, Maia Solange. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Holani, Ravi. University of Calgary. Faculty of Veterinary Medicine. Production Animal Health; Canadá | es_AR |
dc.description.fil | Fil: Shah, Chaitanya B. University of Calgary. Bachelor of Health Sciences; Canadá | es_AR |
dc.description.fil | Fil: Odeon, Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina | es_AR |
dc.description.fil | Fil: Cobo, Eduardo R. University of Calgary. Faculty of Veterinary Medicine. Production Animal Health; Canadá | es_AR |
dc.subtype | cientifico |
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