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Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these
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dc.contributor.author | Jaworski, Juan Pablo | |
dc.contributor.author | Vendrell, Alejandrina | |
dc.contributor.author | Chiavenna, Sebastián Matias | |
dc.date.accessioned | 2018-03-09T14:28:17Z | |
dc.date.available | 2018-03-09T14:28:17Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.other | https://doi.org/10.3389/fimmu.2016.00661 | |
dc.identifier.other | https://www.frontiersin.org/articles/10.3389/fimmu.2016.00661/full | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/2005 | |
dc.description.abstract | Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells. | eng |
dc.format | application/pdf | |
dc.language.iso | eng | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Frontiers in immunology 7 : 661 (March 2017) | |
dc.subject | Virus de la Inmunodeficiencia Humana | |
dc.subject | Human Immunodeficiency Virus | eng |
dc.subject | Anticuerpos Monoclonales | |
dc.subject | Monoclonal Antibodies | eng |
dc.subject | Profilaxis de las Enfermedades | |
dc.subject | Disease Prophylaxis | eng |
dc.title | Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
dc.description.origen | Inst.de Virología | |
dc.gic | 155631 | |
dc.description.fil | Fil: Jaworski, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | |
dc.description.fil | Fil: Vendrell, Alejandrina. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina | |
dc.description.fil | Fil: Chiavenna, Sebastián Matias. Ferrer Advanced Biotherapeutics, Ferrer Internacional; España | |
dc.subtype | cientifico |
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