Comparison of DRB3.2 alleles among false-negative and positive tuberculin skin test cattle with bovine tuberculosis

Abstract

Introduction: M. bovis is worldwide distributed mainly affecting livestock. Caudal Fold-Tuberculin Skin Test (CF-TST) is the primary screening tool that detects the infection in herds. Some tuberculous animals remain undetected (false-negatives) limiting the success of the sanitation programs. Bovine leukocyte antigen (BoLA) DRB3 has been asociated with resistance or susceptibility to several infectious diseases and it is crucial for the antigenic presentation. Characterization of the genetic background among false-negative bovines, related to BoLA DRB3.2, could reveal host aspects associated to this phenotype. Objetive: To identify BoLA-DRB3.2 polimorphysms in false-negative CF-TST cattle, comparing to CF-TST+ bovines in argentinian herds.