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Resumen
Introduction: Bovine tuberculosis (bTB) constitutes a problem for livestock and Public Health due to its negative impact on farms and its zoonotic nature. In Argentina, the application of the National Control and Eradication Program reduced bTB prevalence. Due to its complexity, the disease continues to be a challenge. Vaccination, as a complementary control tool, could reduce its impact on cattle. Currently, there is no commercial vaccine approved for
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dc.contributor.author | Ferrara Muñiz, Ximena | |
dc.contributor.author | Blanco, Federico Carlos | |
dc.contributor.author | Garcia, Elizabeth Andrea | |
dc.contributor.author | Delgado, Fernando Oscar | |
dc.contributor.author | Marfil, Maria Jimena | |
dc.contributor.author | Zumarraga, Martin Jose | |
dc.contributor.author | Cataldi, Angel Adrian | |
dc.contributor.author | Eirin, Maria Emilia | |
dc.date.accessioned | 2024-07-12T11:03:04Z | |
dc.date.available | 2024-07-12T11:03:04Z | |
dc.date.issued | 2024-06 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/18472 | |
dc.description | Poster | |
dc.description.abstract | Introduction: Bovine tuberculosis (bTB) constitutes a problem for livestock and Public Health due to its negative impact on farms and its zoonotic nature. In Argentina, the application of the National Control and Eradication Program reduced bTB prevalence. Due to its complexity, the disease continues to be a challenge. Vaccination, as a complementary control tool, could reduce its impact on cattle. Currently, there is no commercial vaccine approved for its use in bovines. Two attenuated strains, M. bovis Δmce2 and M. bovis Δmce2-phoP1,2 induced protection against a virulent Mycobacterium bovis (M. bovis) strain, during a challenge in cattle3 and the murine model4, respectively. The objective of this work was to evaluate the virulence and safety of M. bovis Δmce2 and M. bovis Δmce2-phoP in mice and guinea pigs, to compare how these two strains behave in both animal models. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | European Society of Mycobacteriology | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | 44th Annual Congress of the European Society of Mycobacteriology. Brujas, Bélgica, 23-26 de junio de 2024 | es_AR |
dc.subject | Mycobacterium bovis | es_AR |
dc.subject | Animal Models | eng |
dc.subject | Modelo Animal | es_AR |
dc.subject | Bovine Tuberculosis | eng |
dc.subject | Tuberculosis Bovina | es_AR |
dc.subject | Virulence | eng |
dc.subject | Virulencia | es_AR |
dc.subject | Safety | eng |
dc.subject | Seguridad | es_AR |
dc.subject | Mice | eng |
dc.subject | Ratón | es_AR |
dc.subject | Guinea Pigs | eng |
dc.subject | Cobaya | es_AR |
dc.title | Comparative study of two deleted Mycobacterium bovis strains in experimental animal models | es_AR |
dc.type | info:ar-repo/semantics/documento de conferencia | es_AR |
dc.type | info:eu-repo/semantics/conferenceObject | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Ferrara Muñiz, Ximena. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Ferrara Muñiz, Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Garcia, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina | es_AR |
dc.description.fil | Fil: Marfil, Maria Jimena. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina | es_AR |
dc.description.fil | Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Cataldi, Angel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Eirin, Maria Emilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Eirin, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.subtype | ponencia |
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