Instituto de Virología: Envíos recientes
Mostrando ítems 21-40 de 236
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A novel bacterial protease inhibitor adjuvant in RBD-based COVID-19 vaccine formulations containing alum increases neutralizing antibodies, specific germinal center B cells and confers protection against SARS-CoV-2 infection in mice
(Frontiers Media, 2022-02)In this work, we evaluated recombinant receptor binding domain (RBD)-based vaccine formulation prototypes with potential for further clinical development. We assessed different formulations containing RBD plus alum, AddaS03, ... -
Longitudinal follow-up of the immunity to SARS-CoV-2 in health care workers in Argentina : persistence of humoral response and neutralizing capacity after Sputnik V vaccination
(American Society for Microbiology, 2023-06)SARS-CoV-2 vaccine protection has encountered waning of immune response and breakthrough infections. The hybrid immune response generated by the combination of vaccination and infection was shown to offer higher and broader ... -
Molecular characterization of group A rotavirus strains detected in alpacas (Vicugna pacos) from Peru
(Microbiology Society, 2021-04)The alpaca is a very important social and economic resource for the production of fibre and meat for Andean communities. Peru is the main producer of alpacas. Group A rotavirus (RVA) has been sporadically detected in ... -
Impact of genetic ancestry on the distribution of interferon-λ4 RS12979860 polymorphism in a global population of Buenos Aires, Argentina = Impacto de la ancestría genética en la distribución del polimorfismo de interferón-λ4 RS12979860 en una población global de Buenos Aires, Argentina
(Sociedad Argentina de Genética, 2022-12)Human interferon-λ4 is a cytokine involved in early stages of antiviral responses. Strikingly, some allelic variants with diminished antiviral activity reduce the susceptibility to viral infections, thus they would have ... -
The MVA vector expressing the F protein of bovine respiratory syncytial virus is immunogenic in systemic and mucosal immunization routes = El vector viral MVA que expresa la proteína F del virus respiratorio sincicial bovino es inmunogénico al administrarse por vía sistémica y por mucosas
(Elsevier, 2023-12)Bovine respiratory syncytial virus (BRSV) affects both beef and dairy cattle, reaching morbidity and mortality rates of 60---80% and 20%, respectively. The aim of this study was to obtain a recombinant MVA expressing the ... -
A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity
(Nature Publishing Group, 2023-10)Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwide. This virus ... -
Serological evidence of SARS-CoV-2 infection in pets naturally exposed during the COVID-19 outbreak in Argentina
(Elsevier, 2022-12)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has rapidly spread worldwide. The monitoring of animals has shown that certain species may be ... -
Probiotic as adjuvant significantly improves protection of the Lanzhou trivalent rotavirus vaccine against heterologous challenge in a gnotobiotic pig model of human rotavirus infection and disease
(MDPI, 2022-09)This preclinical study in the gnotobiotic (Gn) pig model of human rotavirus (HRV) infection and disease evaluates the effect of probiotic Lactobacillus rhamnosus GG (LGG) as a mucosal adjuvant on the immunogenicity and ... -
Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
(MDPI, 2022-10)The gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to the global poultry industry. Two IBV lineages (GI-11 and GI-16) have been widely ... -
Feasibility of polyclonal avian immunoglobulins (IgY) as prophylaxis against human norovirus infection
(MDPI, 2022-11)Background: Human norovirus (HuNoV) is the leading viral cause of diarrhea, with GII.4 as the predominant genotype of HuNoV outbreaks globally. However, new genogroup variants emerge periodically, complicating the development ... -
A new gnotobiotic pig model of P[6] human rotavirus infection and disease for preclinical evaluation of rotavirus vaccines
(MDPI, 2022-12)Human rotavirus (HRV) is a leading cause of gastroenteritis in children under 5 years of age. Licensed vaccines containing G1P[8] and G1-4P[8] strains are less efficacious against newly emerging P[6] strains, indicating ... -
Pandemic (H1N1) 2009 outbreak on pig farm, Argentina
(Centers for Disease Control and Prevention, 2010-02)In June–July 2009, an outbreak of pandemic (H1N1) 2009 infection occurred on a pig farm in Argentina. Molecular analysis indicated that the virus was genetically related to the pandemic (H1N1) 2009 influenza virus strain. ... -
Puesta a punto de una PCR en tiempo real para la detección de Senecavirus A
(Universidad Nacional del Centro de la Provincia de Buenos Aires, 2023-08)Senecavirus A (SVA). Familia : Picornaviridae Única especie del género Senecavirus. No envuelto ARN + monocatenario. La Organización Mundial de Sanidad Animal ( lo considera de gran importancia debido a que sus signos ... -
Primer reporte de ADN proviral del virus de la leucosis bovina detectado en carne destinada a consumo en Argentina
(Universidad Nacional del Centro de la Provincia de Buenos Aires, 2023-08)Virus de la leucosis bovina (BLV). Familia: Retroviridae , Genero: Deltaretrovirus , Genoma: ssRNA. Agente causal de la Leucosis bovina enzoótica. Prevalencia predial: Tambos 80 99 Establecimientos de producción de carne ... -
Detección molecular de Parvovirus equino hepatitis en Argentina
(Universidad Nacional del Centro de la Provincia de Buenos Aires, 2023-08)El nuevo Parvovirus equino hepatitis EqPV H) identificado en 2018 está asociado con hepatitis subclínica a grave en caballos y parece ser el agente etiológico de la enfermedad de Theiler ( Esta enfermedad es una de las ... -
Evaluación de la seguridad viral en productos biológicos
(Universidad Nacional del Centro de la Provincia de Buenos Aires, 2023-08)El desarrollo de productos biofarmacéuticos requiere un control estricto de los procesos de manufactura a fin de obtener un producto seguro para humanos y animales Para esto es fundamental realizar el control de contaminantes ... -
Parvovirus Equino-Hepatitis (EqPV-H) : un nuevo virus contaminante de productos biológicos de origen veterinario = Equine Parvovirus-Hepatitis : A new adventitious agent in veterinary biological products
(Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste, 2023-11)El Parvovirus Equino-Hepatitis (EqPV-H) es un nuevo integrante de la familia Parvoviridae descubierto hace apenas 5 años. Este virus fue identificado en el suero e hígado de un caballo muerto por hepatitis sérica equina, ... -
Seroprevalence and risk factors associated with bovine Leukemia virus infection in argentine beef cattle
(Elsevier, 2023-11)Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, an endemic disease in dairy cattle of Argentina. However, little is known about the seroprevalence of BLV in beef cattle. In this study, we ... -
A novel optimized polyoxometalate-modified silver nanocomposite. Application to the development of antibacterial textiles
(Elsevier, 2023-06)Antimicrobial textiles are used in various settings ranging from households to different industries, health areas, and shops. These materials are used in the manufacture of air filters, food packaging, sportswear; and ... -
Development of a platform process for the production and purification of single‐domain antibodies
(Wiley, 2021-09)Single-domain antibodies (sdAbs) offer the affinity and therapeutic value of conventional antibodies, with increased stability and solubility. Unlike conventional antibodies, however, sdAbs do not benefit from a platform ...