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Mostrando ítems 1-9 de 9
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A phenotypic characterization of two isolates of a multidrug-resistant outbreak strain of mycobacterium tuberculosis with opposite epidemiological fitness
Bei, Jinlong; Bigi, María Mercedes; Lima, Analía; Zhang, Qi; Blanco, Federico Carlos; López, Beatriz; Yu, Ting; Wang, Zhilin; Dai, Zhangyan; Chen, Zhuang; Cataldi, Angel Adrian; Sasiain, María del Carmen; Ritacco, Viviana; De la Barrera, Silvia Susana; Soria, Marcelo Abel; Durán, Rosario; Bigi, Fabiana (Hindawi, 2020-04)Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB ... -
A transcriptional analysis of cattle immune cells reveals a central role of type 1 interferon in the In vitro innate immune response against Mycobacterium bovis
Blanco, Federico Carlos; Bigi, María Mercedes; Garcia, Elizabeth Andrea; Elola, María Teresa; Vazquez, Cristina Lourdes; Bigi, Fabiana (MDPI, 2023-09)Bovine tuberculosis is a chronic infectious disease primarily caused by Mycobacterium bovis, a bacterium that affects cattle and other mammals, including humans. Despite the availability of vast research about the immune ... -
Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles
Bigi, María Mercedes; Vazquez, Cristina Lourdes; Castelão, Ana Beatriz C.; Garcia, Elizabeth Andrea; Cataldi, Angel Adrian; Jackson, Mary; McNeil, Michael; Soria, Marcelo Abel; Zumarraga, Martin Jose; Cabruja, Matias; Gago, Gabriela; Blanco, Federico Carlos; Nishibe, Christiane; Almeida Junior, Nalvo Franco de; Araujo, Flabio Ribeiro de; Bigi, Fabiana (Elsevier, 2019-12)Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic ... -
Characterization of the two component regulatory system PhoPR in Mycobacterium bovis
Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, María Mercedes; Vazquez, Cristina Lourdes; Forrellad, Marina Andrea; Rocha, Rosana Valeria; Golby, Paul; Soria, Marcelo Abel; Bigi, Fabiana (Elsevier, 2018-08)Mycobacterium bovis is the causative agent of bovine tuberculosis and is a member of Mycobacterium tuberculosis complex, which causes tuberculosis in a number of mammals including humans. Previous studies have shown that ... -
Development and evaluation of a low cost IgG ELISA test based in RBD protein for COVID-19
Villafañe, Luciana María; Gallo Vaulet, Maria Lucia; Viere, Florencia M.; Klepp, Laura Ines; Forrellad, Marina Andrea; Bigi, María Mercedes; Romano, Maria Isabel; Magistrelli, Giovanni; Rodríguez Fermepin, Marcelo; Bigi, Fabiana (Elsevier, 2022-01)Serology tests for SARS-CoV-2 have proven to be important tools to fight against the COVID-19 pandemic. These serological tests can be used in low-income and remote areas for patient contact tracing, epidemiologic studies ... -
Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings?
Sabio Y Garcia, Julia Veronica; Bigi, María Mercedes; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, Fabiana (Elsevier, 2020-08)Members of the Mycobacterium tuberculosis complex (MTBC) are responsible for tuberculosis in several mammals. In this complex, Mycobacterium tuberculosis and Mycobacterium bovis, which are closely related, show host ... -
Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
Bigi, María Mercedes; Blanco, Federico Carlos; Araujo, Flabio Ribeiro de; Thacker, Tyler C.; Zumarraga, Martin Jose; Cataldi, Angel Adrian; Soria, Marcelo Abel; Bigi, Fabiana (2016)Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. ... -
Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
Forrellad, Marina Andrea; Vazquez, Cristina Lourdes; Blanco, Federico Carlos; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Rocha, Rosana Valeria; Villafañe, Luciana Maria; Bigi, María Mercedes; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (Taylor & Francis, 2019-12)In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this ... -
Single nucleotide polymorphisms may explain the contrasting phenotypes of two variants of a multidrug-resistant Mycobacterium tuberculosis strain
Bigi, María Mercedes; López, Beatriz; Blanco, Federico Carlos; Sasiain, María del Carmen; De La Barrera, Silvia Susana; Marti, Marcelo Adrián; Sosa, Ezequiel Jorge; Fernandez Do Porto, Darío Augusto; Ritacco, Viviana; Bigi, Fabiana; Soria, Marcelo Abel (2017)Globally, about 4.5% of new tuberculosis (TB) cases are multi-drug-resistant (MDR), i.e. resistant to the two most powerful first-line anti-TB drugs. Indeed, 480,000 people developed MDR-TB in 2015 and 190,000 people died ...