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Evaluation of different heterologous prime-boost immunization strategies against Babesia bovis using viral vectored and protein-adjuvant vaccines based on a chimeric multi-antigen
(2016)Protection against the intraerythrocytic bovine parasite Babesia bovis requires both humoral and cellular immune responses. Therefore, tailored combinations of immunogens targeted at both arms of the immune system are ... -
Expresión de antígenos derivados del virus de la fiebre aftosa en diferentes sistemas eucarióticos
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2000)La fiebre aftosa es una enfermedad de gran importancia económica que afecta principalmente al ganado bovino. Esta enfermedad está causada por un picornavirus, el virus de la fiebre aftosa (VFA). El control de la enfermedad ... -
Higher diversity of Brucella canis in Latin America, according to an MLVA_13 Bc analysis
(Elsevier, 2023-07)Brucella canis is the main causative agent of canine brucellosis, which affects domestic and wild canids and leads to clinical signs and symptoms of the reproductive and locomotor systems. Owing to the scarce information ... -
Identification and evaluation of new Mycobacterium bovis antigens in the in vitro interferon gamma release assay for bovine tuberculosis diagnosis
(Elsevier, 2015-12)Bovine tuberculosis (bTB) is a common zoonotic disease, caused by Mycobacterium bovis (M. bovis), responsible for significant economic losses worldwide. Its diagnosis is based on the detection of cell mediated immunity ... -
Immunohistochemical detection of pro-inflammatory and anti-inflammatory cytokines in granulomas in cattle with natural Mycobacterium bovis infection
(2017)Cellular immune response was evaluated in lymph nodes and lung with different granulomatous lesions from cattle naturally infected with Mycobacterium bovis. For this purpose, we assessed pro-inflammatory and anti-inflamm ... -
Immunomodulatory effect of baculovirus in chickens : how it modifies the immune response against infectious bursal disease virus
(2016)Several reports have shown that baculoviruses (BVs) have strong adjuvant properties on the mammalian immune system. Recent studies of our group demonstrated the ability of BV to stimulate the innate immunity in chickens. ... -
Induction of both local immune response in mice and protection in a rabbit model by intranasal immunization with modified vaccinia ankara virus expressing a secreted form of bovine herpesvirus 1 glycoprotein D
(2017)In this study, we evaluated the immunogenicity and efficacy of mucosal delivery of a recombinant modified vaccinia Ankara virus (MVA) expressing the secreted version of bovine herpesvirus type 1 (BoHV-1) glycoprotein D ... -
Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein
(Elsevier, 2015-09)Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF ... -
Mycobacterium bovis requires P27 (LprG) to arrest phagosome maturation and replicate within bovine macrophages
(2017-03)Mycobacterium bovis causes tuberculosis in a wide variety of mammals, with strong tropism for cattle and eventually humans. P27, also called LprG, is among the proteins involved in the mechanisms of the virulence and ... -
Nuevas estrategias para el diagnóstico de la tuberculosis y paratuberculosis bovina
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2015-09)La Tuberculosis (TBB) y Paratuberculosis bovina (PTB) son las principales enfermedades que limitan el desarrollo de la industria lechera y de la carne en Argentina, siendo importantes en el contexto de la Sanidad animal ... -
Overexpressed proteins in hypervirulent clade 8 and clade 6 strains of Escherichia coli O157:H7 compared to E. coli O157:H7 EDL933 clade 3 strain
(2016)Escherichia coli O157:H7 is responsible for severe diarrhea and hemolytic uremic syndrome (HUS), and predominantly affects children under 5 years. The major virulence traits are Shiga toxins, necessary to develop HUS and ... -
Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina
(2016)Foot-and-mouth disease (FMD) is a highly transmissible disease of hooved livestock. Although FMD has been eradicated from many countries, economic and social consequences of FMD reintroductions are devastating. After ... -
Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
(2016)Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. ... -
Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens
(2016)To study the in vivo distribution of the CNPV viral vector, we conducted two trials. In the first trial, six 11- day-old SPF chickens were intramuscularly vaccinated in one leg with CN048-VP2 (106 plaque-forming units ... -
Respuesta inmune en terneros experimentalmente infectados con diferentes dosis de Mycobacterium bovis
(Gerencia de Comunicación e Imagen Institucional, DNA SICC, INTA, 2011-08)La tuberculosis bovina es una enfermedad zoonótica producida por Mycobacterium bovis que afecta a animales de producción causando pérdidas económicas y representa, además, un problema para la salud pública. El conocimiento ... -
Tuberculosis bovina : transmisibilidad de cepas de Mycobacterium bovis y detección de micobacterias en menudencias comercializadas en bocas de expendio de carne
(Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, 2019)La tuberculosis bovina, causada por Mycobacterium bovis (M. bovis), es endémica en la Argentina. Su presencia en el ganado bovino representa un riesgo para la salud humana debido a su carácter zoonótico, pudiendo además ... -
Use of molecular tools for the diagnosis of rangeliosis by Rangelia vitalii in Argentina: A case report
(Elsevier, 2020-07)Vector-borne pathogens are responsible for serious emerging diseases and Rangelia vitalii, the etiologic agent of canine rangeliosis, is one of the most pathogenic tick-borne pathogens for dogs in South America. This ... -
Uso de Brucella abortus como vector para la expresión de antígenos heterólogos
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2012-03)La brucelosis es una zoonosis bacteriana causada por especies del género Brucella. B. abortus S19 es la cepa vacunal en uso en nuestro país. Debido a su capacidad para despertar una respuesta inmune celular y humoral, B. ... -
VP1 protein of Foot-and-mouth disease virus (FMDV) impairs baculovirus surface display
(Elsevier, 2013-07)The Foot-and-mouth disease virus (FMDV) causes important economical losses in livestock farming. In order to develop a novel subunit vaccine against FMDV, we constructed recombinant baculoviruses that display the protein ... -
Zoonosis por parapoxvirus: diagnóstico e identificación de pseudocowpox (PCPV)
(Estación Experimental Agropecuaria General Villegas, INTA, 2021)Las zoonosis son enfermedades infecciosas que han pasado de un animal a humanos y representan un gran porcentaje de todas las enfermedades infecciosas recientemente identificadas, así como de muchas de las ya existentes. ...