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A fungal protease named AsES triggers antiviral immune responses and effectively restricts virus infection in arabidopsis and Nicotiana benthamiana plants
(Oxford University Press, 2022-04)Background and Aims: Plants have evolved complex mechanisms to fight against pathogens. Among these mechanisms, pattern-triggered immunity (PTI) relies on the recognition of conserved microbe- or pathogen-associated molecular ... -
A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice
(Elsevier, 2022-09)In the intraerythrocytic protozoan parasites of the genus Babesia both innate and adaptive immune responses are necessary to confer protection against clinical disease. In particular, the adaptive immune response involves ... -
A transcriptional analysis of cattle immune cells reveals a central role of type 1 interferon in the In vitro innate immune response against Mycobacterium bovis
(MDPI, 2023-09)Bovine tuberculosis is a chronic infectious disease primarily caused by Mycobacterium bovis, a bacterium that affects cattle and other mammals, including humans. Despite the availability of vast research about the immune ... -
Baculovirus capsid display in vaccination schemes: effect of a previous immunity against the vector on the cytotoxic response to delivered antigens
(Springer, 2018-12)The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, although it also has been used as display vector for vaccine development. In this ... -
Bovine macrophages responses to the infection with virulent and attenuated Leptospira interrogans serovar Pomona
(Elsevier, 2019-06)Leptospirosis is a zoonosis, caused by pathogenic spirochetes of the genus Leptospira. Although cattle are usually the maintenance hosts of serovar Hardjo, Pomona is the most frequent serovar circulating in Argentina. The ... -
Desarrollo y evaluación de un candidato vacunal para IBD producido en plantas: una alternativa a las vacunas tradicionales
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2018)El Virus de la enfermedad infecciosa de la bursa (IBDV) es el agente etiológico responsable de una enfermedad aguda contagiosa e inmunosupresora que afecta pollos jóvenes y causa importantes pérdidas económicas. La vacunación ... -
Developments in plant-based vaccines against diseases of concern in developing countries
(BENTHAM Open, 2010)Vaccination has been extensively used to prevent, eradicate and control infectious diseases. However, the development and implementation of new vaccines remains prohibitively expensive for middle and low income countries where ... -
Editorial : Vaccination strategies against ruminant infectious diseases
(Frontiers Media, 2023-05)Ruminant infectious diseases cause economic impact through losses in animal production and human health. Most of the commercially available veterinary vaccines are live attenuated or inactivated which induce different ... -
ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
(Karger, 2017-12)Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses ... -
Estudio de la relación del virus de la Bursitis Infecciosa con su hospedador. Análisis de la respuesta inmune y de la función y localización de la proteína viral VP5
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2015)Las aves representan un eslabón fundamental en la economía internacional. A nivel mundial, alrededor del 40% de la carne consumida es de origen aviar. La industria avícola ha experimentado en los últimos años un crecimiento ... -
Evaluation of a virulent strain of Mycobacterium avium subsp. Paratuberculosis used as a heat-killed vaccine
(Elsevier, 2021-11)Bovine paratuberculosis is one of the most important chronic infectious diseases in livestock. This disease is difficult to control because of its inefficient management (test and cull strategy and inadequate biosecurity). ... -
Exploring sunflower responses to Sclerotinia head rot at early stages of infection using RNA‑seq analysis
(Springer Nature, 2020-08)Sclerotinia head rot (SHR), caused by the necrotrophic fungus Sclerotinia sclerotiorum, is one of the most devastating sunflower crop diseases. Despite its worldwide occurrence, the genetic determinants of plant resistance ... -
IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis
(Taylor & Francis, 2014-11)Protective immunity against Mycobacterium tuberculosis (Mtb) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent Mtb in macrophage cell lines. We investigated the contribution of ... -
In vivo short-term exposure to residual oil fly ash impairs pulmonary innate immune response against environmental mycobacterium infection
(Wiley, 2015-05)Epidemiological studies have shown that pollution derived from industrial and vehicular transportation induces adverse health effects causing broad ambient respiratory diseases. Therefore, air pollution should be taken ... -
Klebsiella pneumoniae ST258 negatively regulates the oxidative burst in human neutrophils
(Frontiers Media, 2019-04)The epidemic clone of Klebsiella pneumoniae (Kpn), sequence type 258 (ST258), carbapenamase producer (KPC), commonly infects hospitalized patients that are left with scarce therapeutic option since carbapenems are last ... -
The localization of a heterologous displayed antigen in the baculovirus-budded virion determines the type and strength of induced adaptive immune response
(2017-05)In the search of strategies of presentation of heterologous antigens to elicit humoral or cellular immune responses that modulate and properly potentiate each type of response, researchers have been studying baculovirus ... -
MVAΔ008 viral vector encoding the model protein OVA induces improved immune response against the heterologous antigen and equal levels of protection in a mice tumor model than the conventional MVA
(Elsevier, 2021-11)Modified vaccinia Ankara virus (MVA) is extensively used as a vaccine vector. We have previously observed that MVAΔ008, an MVA lacking the gene that codes for interleukin-18 binding protein, significantly increases CD8+ ... -
Protection efficacy of Argentinian isolates of Mycobacterium avium subsp. paratuberculosis with different genotypes and virulence in a murine model
(Elsevier, 2018-12)Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include ... -
Recent advances in non-specific immune memory against bovine tuberculosis
(Elsevier, 2021-04)Bovine tuberculosis is an important worldwide disease mainly related to cattle, although it also affects other mammals, including humans. In recent years, there have been considerable advances in the knowledge of the immune ... -
Respuesta inmune en terneros experimentalmente infectados con diferentes dosis de Mycobacterium bovis
(Gerencia de Comunicación e Imagen Institucional, DNA SICC, INTA, 2011-08)La tuberculosis bovina es una enfermedad zoonótica producida por Mycobacterium bovis que afecta a animales de producción causando pérdidas económicas y representa, además, un problema para la salud pública. El conocimiento ...