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Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle
Di Giacomo, Sebastián; Bucafusco, Danilo; Schammas, Juan Manuel; Pega, Juan Franco; Miraglia, Maria Cruz; Barrionuevo, Florencia Mabel; Capozzo, Alejandra; Perez Filgueira, Daniel Mariano (MDPI, 2022-08)Foot-and-mouth disease (FMD) remains one of the major threats to animal health worldwide. Its causative agent, the FMD virus (FMDV), affects cloven-hoofed animals, including farm animals and wildlife species, inflicting ... -
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle
Pega, Juan Franco; Bucafusco, Danilo; Di Giacomo, Sebastián; Schammas, Juan Manuel; Malacari, Darío Amilcar; Capozzo, Alejandra Victoria; Arzt, J.; Pérez-Beascoechea, C.; Maradei, E.; Rodríguez, L.L.; Borca, Manuel Victor; Perez Filgueira, Daniel Mariano (2013-03)Foot-and-mouth disease (FMD) is a highly contagious viral disease which affects both domestic and wild biungulate species. This acute disease, caused by the FMD virus (FMDV), usually includes an active replication phase ... -
Foot-and-mouth disease vaccination induces cross-reactive IFN-γ responses in cattle that are dependent on the integrity of the 140S particles
Bucafusco, Danilo; Di Giacomo, Sebastián; Pega, Juan Franco; Schammas, Juan Manuel; Cardoso, Nancy Patricia; Capozzo, Alejandra Victoria; Perez Filgueira, Daniel Mariano (2015-02)Interferon-γ (IFN-γ) recall responses against foot-and-mouth disease virus (FMDV) in FMD vaccinated cattle are utilized to study T-lymphocyte immunity against this virus. Here, a recall IFN-γ assay based on a commercial ... -
Immune Response and Partial Protection against Heterologous Foot-and-Mouth Disease Virus Induced by Dendrimer Peptides in Cattle
Soria, Ivana; Quattrocchi, Valeria; Langellotti, Cecilia Ana; Perez Filgueira, Daniel Mariano; Pega, Juan Franco; Gnazzo, Victoria; Romera, Sonia Alejandra; Schammas, Juan Manuel; Bucafusco, Danilo; Di Giacomo, Sebastián; García de la Torre, Beatriz; Andreu, David; Sobrino, Francisco; Blanco, Esther; Zamorano, Patricia Ines (2018-04)Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to ... -
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines
Bucafusco, Danilo; Di Giacomo, Sebastián; Pega, Juan Franco; Juncos, María Sol; Schammas, Juan Manuel; Perez Filgueira, Daniel Mariano; Capozzo, Alejandra Victoria (2014-11-12)Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred ... -
SARS-CoV-2 specific nanobodies neutralize different variants of concern and reduce virus load in the brain of h-ACE2 transgenic mice
Pavan, Florencia; Bok, Marina; Betanzos San Juan, Rafael; Malito, Juan Pablo; Marcoppido, Gisela Ariana; Franco, Diego Rafael; Militelo, Daniela Ayelen; Schammas, Juan Manuel; Bari, Sara Elizabeth; Stone, William B.; López, Krisangel; Porier, Danielle LaBrie; Muller, John Anthony; Auguste, Albert J.; Yuan, Lijuan; Wigdorovitz, Andres; Parreño, Gladys Viviana; Ibañez, Lorena Itat (MDPI, 2024-02)Since the beginning of the COVID-19 pandemic, there has been a significant need to develop antivirals and vaccines to combat the disease. In this work, we developed llama-derived nanobodies (Nbs) directed against the ... -
Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge
Barrionuevo, Florencia Mariel; Di Giacomo, Sebastián; Bucafusco, Danilo; Ayude, Andrea Fabiana; Schammas, Juan Manuel; Miraglia, María Cruz; Capozzo, Alejandra Victoria; Borca, Manuel Victor; Perez Filgueira, Daniel Mariano (2018-05)The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days ... -
Systemic Foot-and-Mouth Disease Vaccination in Cattle Promotes Specific Antibody-Secreting Cells at the Respiratory Tract and Triggers Local Anamnestic Responses upon Aerosol Infection
Pega, Juan Franco; Di Giacomo, Sebastián; Bucafusco, Danilo; Schammas, Juan Manuel; Malacari, Darío Amilcar; Barrionuevo, Florencia Mariel; Capozzo, Alejandra Victoria; Rodríguez, L.L.; Borca, Manuel Victor; Perez Filgueira, Daniel Mariano (2015-09)Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting biungulate species. Commercial vaccines, formulated with inactivated FMD virus (FMDV), are regularly used worldwide to control the disease. Here, ...