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Mostrando ítems 21-34 de 34
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In vivo subcellular localization of Mal de Río Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions
Maroniche, Guillermo Andrés; Mongelli, Vanesa Claudia; Llauger, Gabriela; Alfonso, Victoria; Taboga, Oscar Alberto; Del Vas, Mariana (Elsevier, 2012-09)The in vivo subcellular localization of Mal de Río Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution ... -
The localization of a heterologous displayed antigen in the baculovirus-budded virion determines the type and strength of induced adaptive immune response
Tavarone, Maria Eugenia; Molina, Guido Nicolas; Amalfi, Sabrina; Peralta, Andrea Veronica; Molinari, Maria Paula; Taboga, Oscar Alberto; Diaz, Silvio Ricardo; Gravisaco, María José (2017-05)In the search of strategies of presentation of heterologous antigens to elicit humoral or cellular immune responses that modulate and properly potentiate each type of response, researchers have been studying baculovirus ... -
Molecular identification of a cyclodextrin glycosyltransferase-producing microorganism and phylogenetic assessment of enzymatic activities
Caminata Landriel, Soledad; Castillo, Julieta D. L. M.; Taboga, Oscar Alberto; Ferrarotti, Susana Alicia; Gottlieb, Alexandra Marina; Costa, Hernán (Academia Brasileira de Ciências, 2019-10)Cyclodextrin glycosyltransferases (CGTases) are important enzymes in the biotechnology field because they catalyze starch conversion into cyclodextrins and linear oligosaccharides, which are used in food, pharmaceutical ... -
Novel biotechnological platform based on baculovirus occlusion bodies carrying Babesia bovis small antigenic peptides for the design of a diagnostic enzyme-linked immunosorbent assay (ELISA)
Lopez, Maria Gabriela; Pallares, H.M.; Alfonso, Victoria; Carmona, S. J.; Farber, Marisa Diana; Taboga, Oscar Alberto; Wilkowsky, Silvina Elizabeth (Springer, 2018-01)Baculoviruses are large DNA virus of insects principally employed in recombinant protein expression. Its ability to form occlusion bodies (OBs), which are composed mainly of polyhedrin protein (POLH), makes them ... -
P26 enhances baculovirus gene delivery by modulating the mammalian antiviral response
Amalfi, Sabrina; Plastine, María Del Pilar; Lopez, Maria Gabriela; Gravisaco, María José; Taboga, Oscar Alberto; Alfonso, Victoria (Springer, 2023-08)Poxins are poxviral proteins that act by degrading 2´3´-cGAMP, a key molecule of cGAS-STING axis that drives and amplifies the antiviral response. Previous works have described some poxin homologous among lepidopteran and ... -
Rapid and cost-effective process based on insect larvae for scale-up production of SARS-COV-2 spike protein for serological COVID-19 testing
Smith, Ignacio; Mc Callum, Gregorio Juan; Sabljic, Adriana Victoria; Marfia, Juan Ignacio; Bombicino, Silvina Sonia; Trabucchi, Aldana; Iacono, Ruben Francisco; Birenbaum, Joaquín Manuel; Vazquez, Susana Claudia; Minoia, Juan Mauricio; Cascone, Osvaldo; Lopez, Maria Gabriela; Taboga, Oscar Alberto; Targovnik, Alexandra Marisa; Wolman, Federico Javier; Fingermann, Matías; Alonso, Leonardo Gabriel; Valdez, Silvina Noemí; Miranda, María Victoria (Wiley, 2021-10)Serology testing for COVID-19 is important in evaluating active immune response against SARS-CoV-2, studying the antibody kinetics, and monitoring reinfections with genetic variants and new virus strains, in particular, ... -
Recombinant occlusion bodies of baculovirus as carriers of a nonstructural protein of foot-and-mouth disease virus
Diez, Michay; Trotta, Myrian Vanesa; Alfonso, Victoria; Taboga, Oscar Alberto; Lopez, Maria Gabriela (Springer, 2018-11)Here, we developed a diagnostic ELISA for foot-and-mouth disease using recombinant occlusion bodies (rOBs) of baculovirus. We fused Δ3AB1–3, a polypeptide derived from non-structural proteins of foot-and-mouth disease ... -
Successful production of the potato antimicrobial peptide Snakin-1 in baculovirus-infected insect cells and development of specific antibodies
Almasia, Natalia Ines; Molinari, Maria Paula; Maroniche, Guillermo Andrés; Nahirñak, Vanesa; Barrios Baron, Maria Pilar; Taboga, Oscar Alberto; Vazquez Rovere, Cecilia (2017)Background: Snakin-1 (StSN1) is a broad-spectrum antimicrobial cysteine-rich peptide isolated from Solanum tuberosum. Its biotechnological potential has been already recognized since it exhibits in vivo antifungal and ... -
Surface Display of AcMNPV Occlusion-Derived P74 Does Not Enhance Oral Infectivity of Budded Viruses
Alfonso, Victoria; Lopez, Maria Gabriela; Carrillo, Elisa Cristina; Taboga, Oscar Alberto (S. Karger AG, 2012-02)Baculovirus occlusion-derived viruses (ODVs) and budded viruses (BVs) are morphologically and functionally distinct. ODVs are responsible for primary infection in insect hosts because of their high per os infectivity. On ... -
The autographa californica multiple nucleopolyhedrovirus Ac12: A non-essential F box-like protein that interacts with cellular SKP1 component of the E3 ubiquitin ligase complex
Costa Navarro, Guadalupe Soledad; Amalfi, Sabrina; Lopez, Maria Gabriela; Llauger, Gabriela; Arneodo Larochette, Joel Demian; Taboga, Oscar Alberto; Alfonso, Victoria (Elsevier, 2019-01)The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac12 gene, which is conserved in ten other baculovirus, codes a predicted 217 amino acid protein of unknown function. In this study, we investigated the ... -
TLR9 activation is required for cytotoxic response elicited by baculovirus capsid display
Molinari, Maria Paula; Crespo, Maria Ines; Molina, Guido Nicolas; Dho, Nicolás D.; Marinho, Fábio V.; Maletto, Belkys Angélica; Leclerc, Claude; Oliveira, Sergio C.; Taboga, Oscar Alberto; Cebrian, Ignacio; Moron, Victor Gabriel (Wiley, 2023-05)Although the baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, represents an efficient vector for vaccine development. Baculovirus surface ... -
Trans-complementation of polyhedrin by a stably transformed Sf9 insect cell line allows occ− baculovirus occlusion and larval per os infectivity
López, María Gabriela; Alfonso, Victoria; Carrillo, Elisa Cristina; Taboga, Oscar Alberto (Elsevier, 2010-01-15)Oral infection of insect larvae with baculovirus is an advantageous methodology for producing high levels of recombinant proteins and for achieving plague control. However, many recombinant baculoviruses express a foreign ... -
Two distinctive phenotypes of AcMNPV display different immune abilities and intracellular destiny
Molina, Guido Nicolas; Tavarone, Maria Eugenia; Taboga, Oscar Alberto; Molinari, Maria Paula (2016-12-29)The budded phenotype (BV) of the baculovirus AcMNPV has been demonstrated to have strong immunostimulatory properties that are relevant for the development of vaccines and antiviral therapies. Although the occluded ... -
VP1 protein of Foot-and-mouth disease virus (FMDV) impairs baculovirus surface display
Peralta, Andrea Veronica; Maroniche, Guillermo Andrés; Alfonso, Victoria; Molinari, Maria Paula; Taboga, Oscar Alberto (Elsevier, 2013-07)The Foot-and-mouth disease virus (FMDV) causes important economical losses in livestock farming. In order to develop a novel subunit vaccine against FMDV, we constructed recombinant baculoviruses that display the protein ...