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Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwide. This virus undergoes epochal evolution with periodic emergence of variants with new antigenic profiles and altered specificity for histo-blood group antigens (HBGA), the determinants of cell attachment and susceptibility, hampering the development
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dc.contributor.author | Salmen, Wilhelm | |
dc.contributor.author | Hu, Liya | |
dc.contributor.author | Bok, Marina | |
dc.contributor.author | Chaimongkol, Natthawan | |
dc.contributor.author | Ettayebi, Khalil | |
dc.contributor.author | Sosnovtsev, Stanislav V. | |
dc.contributor.author | Soni, Kaundal | |
dc.contributor.author | Ayyar, B. Vijayalakshmi | |
dc.contributor.author | Shanker, Sreejesh | |
dc.contributor.author | Neill, Frederick H. | |
dc.contributor.author | Sankaran, Banumathi | |
dc.contributor.author | Atmar, Robert L. | |
dc.contributor.author | Estes, Mary K. | |
dc.contributor.author | Green, Kim Y. | |
dc.contributor.author | Parreño, Gladys Viviana | |
dc.contributor.author | Prasad, B. V. Venkataram | |
dc.date.accessioned | 2024-01-09T15:51:32Z | |
dc.date.available | 2024-01-09T15:51:32Z | |
dc.date.issued | 2023-10 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | https://doi.org/10.1038/s41467-023-42146-0 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/16493 | |
dc.identifier.uri | https://www.nature.com/articles/s41467-023-42146-0 | |
dc.description.abstract | Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwide. This virus undergoes epochal evolution with periodic emergence of variants with new antigenic profiles and altered specificity for histo-blood group antigens (HBGA), the determinants of cell attachment and susceptibility, hampering the development of immunotherapeutics. Here, we show that a llama-derived nanobody M4 neutralizes multiple GII.4 variants with high potency in human intestinal enteroids. The crystal structure of M4 complexed with the protruding domain of the GII.4 capsid protein VP1 revealed a conserved epitope, away from the HBGA binding site, fully accessible only when VP1 transitions to a “raised” conformation in the capsid. Together with dynamic light scattering and electron microscopy of the GII.4 VLPs, our studies suggest a mechanism in which M4 accesses the epitope by altering the conformational dynamics of the capsid and triggering its disassembly to neutralize GII.4 infection. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Nature Publishing Group | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | Nature Communications 14 : 6516 (Octubre 2023) | es_AR |
dc.subject | Antigens | eng |
dc.subject | Antígenos | es_AR |
dc.subject | Nanotecnología | |
dc.subject | Nanotechnology | eng |
dc.subject.other | Noroviruses | eng |
dc.subject.other | Norovirus | es_AR |
dc.subject.other | Capsid Plasticity | eng |
dc.subject.other | Plasticidad de la Cápside | es_AR |
dc.title | A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | Instituto de Virología | es_AR |
dc.description.fil | Fil: Salmen, Wilhelm. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados Unidos | es_AR |
dc.description.fil | Fil: Hu, Liya. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados Unidos | es_AR |
dc.description.fil | Fil: Bok, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnologicas; Argentina | es_AR |
dc.description.fil | Fil: Bok, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Chaimongkol, Natthawan. National Institutes of Health. National Institute of Allergy and Infectious Diseases. Caliciviruses Section; Estados Unidos | es_AR |
dc.description.fil | Fil: Ettayebi, Khalil. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados Unidos | es_AR |
dc.description.fil | Fil: Sosnovtsev, Stanislav V. National Institutes of Health. National Institute of Allergy and Infectious Diseases. Caliciviruses Section; Estados Unidos | es_AR |
dc.description.fil | Fil: Soni, Kaundal. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados Unidos | es_AR |
dc.description.fil | Fil: Ayyar, B. Vijayalakshmi. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados Unidos | es_AR |
dc.description.fil | Fil: Shanker, Sreejesh. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados Unidos | es_AR |
dc.description.fil | Fil: Neill, Frederick H. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados Unidos | es_AR |
dc.description.fil | Fil: Sankaran, Banumathi. Berkeley Center for Structural Biology. Molecular Biophysics and Integrated Bioimaging. Lawrence Berkeley Laboratory; Estados Unidos | es_AR |
dc.description.fil | Fil: Atmar, Robert L. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados Unidos | es_AR |
dc.description.fil | Fil: Atmar, Robert L. Baylor College of Medicine. Department of Medicine; Estados Unidos | es_AR |
dc.description.fil | Fil: Estes, Mary K. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados Unidos | es_AR |
dc.description.fil | Fil: Estes, Mary K. Baylor College of Medicine. Department of Medicine; Estados Unidos | es_AR |
dc.description.fil | Fil: Green, Kim Y. National Institutes of Health. National Institute of Allergy and Infectious Diseases. Caliciviruses Section; Estados Unidos | es_AR |
dc.description.fil | Fil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virologia e Innovaciones Tecnologicas (IVIT); Argentina | es_AR |
dc.description.fil | Fil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Prasad, B. V. Venkataram. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados Unidos | es_AR |
dc.description.fil | Fil: Prasad, B. V. Venkataram. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados Unidos | es_AR |
dc.subtype | cientifico |
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