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Resumen
This study aimed to evaluate how the method of body weight estimation of a herd (average vs individual) for drug dosing may affect the pharmacokinetics and therapeutic efficacy of ivermectin 3.15% against Rhipicephalus (Boophilus) microplus. The trial was performed in two populations of R. (B.) microplus with different levels of susceptibility to ivermectin: San Martín (SM) (incipient resistance) and Colonia Benítez (CB) (susceptible). Twenty-one (SM) and [ver mas...]
dc.contributor.authorMiro, Maria Victoria
dc.contributor.authorSarli, Macarena
dc.contributor.authorRossner, Maria Victoria
dc.contributor.authorGomez, Viviana Daniela
dc.contributor.authorToffaletti, Jose Rodolfo
dc.contributor.authorLifschitz, Adrian Luis
dc.contributor.authorNava, Santiago
dc.date.accessioned2022-09-14T15:38:04Z
dc.date.available2022-09-14T15:38:04Z
dc.date.issued2022-08
dc.identifier.issn1362-1971 (Print)
dc.identifier.issn2056-6069 (Online)
dc.identifier.otherhttps://doi.org/10.11158/saa.27.9.9
dc.identifier.urihttp://hdl.handle.net/20.500.12123/12882
dc.identifier.urihttps://www.biotaxa.org/saa/article/view/74789
dc.description.abstractThis study aimed to evaluate how the method of body weight estimation of a herd (average vs individual) for drug dosing may affect the pharmacokinetics and therapeutic efficacy of ivermectin 3.15% against Rhipicephalus (Boophilus) microplus. The trial was performed in two populations of R. (B.) microplus with different levels of susceptibility to ivermectin: San Martín (SM) (incipient resistance) and Colonia Benítez (CB) (susceptible). Twenty-one (SM) and forty-two (CB) 12-month-old Braford heifers, naturally infested with R. (B.) microplus, were individually weighed and divided into three groups (G). G1 and G2 were treated with a dose of ivermectin 3.15% (IVOMEC GOLD®) at a dose rate of 630 μg/kg of body weight (1 mL/50 kg). G1 received a uniform dose of ivermectin calculated according to the average of the individual body weights. G2 received a dose of ivermectin calculated according to the exact body weight of each animal. G3 were the control group. Ivermectin concentrations were measured from blood samples from day 1 to day 21 post-treatment. The efficacy of the treatment was evaluated by counting female ticks. In both populations the differences in the doses of ivermectin administered did not affect the pharmacokinetics and therapeutic efficacy of the drug. Nevertheless, it is necessary to avoid the sub-dosage of cattle to reduce the selection pressure for resistance on the tick populations.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherSystematic and Applied Acarology Societyes_AR
dc.relationinfo:eu-repograntAgreement/INTA/2019-PE-E5-I109-001/2019-PE-E5-I109-001/AR./Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y laes_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceSystematic and Applied Acarology 27 (9) : 1800-1812. (2022)es_AR
dc.subjectRhipicephaluses_AR
dc.subjectBoophilus micropluses_AR
dc.subjectBody Weighteng
dc.subjectPeso Corporales_AR
dc.subjectEstimaciónes_AR
dc.subjectValuationeng
dc.subjectCattleeng
dc.subjectGanado Bovinoes_AR
dc.subjectIvermectineng
dc.subjectIvermectinaes_AR
dc.subject.otherGarrapatas
dc.subject.otherTickseng
dc.titleInfluence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) micropluses_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEEA Rafaelaes_AR
dc.description.filFil: Miró, María Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
dc.description.filFil: Miró, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
dc.description.filFil: Sarli, Macarena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
dc.description.filFil: Sarli, Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
dc.description.filFil: Rossner, Maria Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benitez; Argentina
dc.description.filFil: Gomez, Viviana Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benitez; Argentina
dc.description.filFil: Toffaletti, Jose Rodolfo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria El Colorado; Argentina
dc.description.filFil: Lifschitz, Adrian Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
dc.description.filFil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
dc.description.filFil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
dc.description.filFil: Nava, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
dc.subtypecientifico


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