Temas 

Temas

Mostrando ítems 1-12 de 12

    • A phenotypic characterization of two isolates of a multidrug-resistant outbreak strain of mycobacterium tuberculosis with opposite epidemiological fitness 

      Bei, Jinlong; Bigi, María Mercedes; Lima, Analía; Zhang, Qi; Blanco, Federico Carlos; López, Beatriz; Yu, Ting; Wang, Zhilin; Dai, Zhangyan; Chen, Zhuang; Cataldi, Angel Adrian; Sasiain, María del Carmen; Ritacco, Viviana; De la Barrera, Silvia Susana; Soria, Marcelo Abel; Durán, Rosario; Bigi, Fabiana (Hindawi, 2020-04)
      Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB ...

    • Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? 

      Sabio Y Garcia, Julia Veronica; Bigi, María Mercedes; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, Fabiana (Elsevier, 2020-08)
      Members of the Mycobacterium tuberculosis complex (MTBC) are responsible for tuberculosis in several mammals. In this complex, Mycobacterium tuberculosis and Mycobacterium bovis, which are closely related, show host ...

    • FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis 

      Mondino, Sonia; Vazquez, Cristina Lourdes; Cabruja, Matias; Sala, Claudia; Cazenave-Gassiot, Amaury; Blanco, Federico Carlos; Wenk, Markus R.; Bigi, Fabiana; Cole, Stewart T.; Gramajo, Hugo; Gago, Gabriela (Frontiers Media, 2020-10)
      Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is the world’s leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition ...

    • Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts 

      Morcillo, Nora; Imperiale, Belen Rocio; Di Giulio, Angela Beatríz; Zumarraga, Martin Jose; Takif, Howard; Cataldi, Angel Adrian (Elsevier, 2014-12)
      There has been an on-going debate on whether the development of drug resistance in Mycobacterium tuberculosis reduces its relative fitness and its ability to cause disease. The aim of this study was to explore this ...

    • IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis 

      Rovetta, Ana Inés; Peña, Delfina; Hernández del Pino, Rodrigo Emanuel; Recalde, Gabriela María; Pellegrini, Joaquín Miguel; Bigi, Fabiana; Musella, Rosa María; Palmero, Domingo; Gutierrez, Marisa; Colombo, Maria Isabel; García, Verónica Edith (Taylor & Francis, 2014-11)
      Protective immunity against Mycobacterium tuberculosis (Mtb) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent Mtb in macrophage cell lines. We investigated the contribution of ...

    • Mycobacterial MCE proteins as transporters that control lipid homeostasis of the cell wall 

      Klepp, Laura Ines; Sabio Y Garcia, Julia Veronica; Bigi, Fabiana (Elsevier, 2022-01)
      Mammalian cell entry (mce) genes are not only present in genomes of pathogenic mycobacteria, including Mycobacterium tuberculosis (the causative agent of tuberculosis), but also in saprophytic and opportunistic mycobacterial ...

    • Mycobacterium tuberculosis infection in a free‑ranging urban dog from Argentina 

      Marfil, Maria Jimena; Barandiaran, Soledad; Zumarraga, Martin Jose; Germani, Ludmila; Faccini, Tamara; Linares, Marcelo; Capra, Silvana; Gramajo, Laura; Martinez Vivot, Marcela; Falzoni, Elvira (Springer, 2022-02)
      Mycobacterium bovis and Mycobacterium avium are the most important Mycobacteria isolated from diseased dogs, but Mycobacterium tuberculosis can be isolated as well, especially when close contact with humans exists. Free ...

    • Rv2577 of Mycobacterium tuberculosis is a virulence factor with dual phosphatase and phosphodiesterase functions 

      Forrellad, Marina Andrea; Blanco, Federico Carlos; Marrero Diaz De Vill, Rubén; Vazquez, Cristina Lourdes; Yaneff, Agustín; Garcia, Elizabeth Andrea; Gutierrez, Maximiliano Gabriel; Durán, Rosario; Villarino, Andrea; Bigi, Fabiana (Frontiers Media, 2020-10)
      Tuberculosis, a lung disease caused by Mycobacterium tuberculosis (Mtb), is one of the ten leading causes of death worldwide affecting mainly developing countries. Mtb can persist and survive inside infected cells through ...

    • Single nucleotide polymorphisms may explain the contrasting phenotypes of two variants of a multidrug-resistant Mycobacterium tuberculosis strain 

      Bigi, María Mercedes; López, Beatriz; Blanco, Federico Carlos; Sasiain, María del Carmen; De La Barrera, Silvia Susana; Marti, Marcelo Adrián; Sosa, Ezequiel Jorge; Fernandez Do Porto, Darío Augusto; Ritacco, Viviana; Bigi, Fabiana; Soria, Marcelo Abel (2017)
      Globally, about 4.5% of new tuberculosis (TB) cases are multi-drug-resistant (MDR), i.e. resistant to the two most powerful first-line anti-TB drugs. Indeed, 480,000 people developed MDR-TB in 2015 and 190,000 people died ...

    • Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis 

      Forrellad, Marina Andrea; Bianco, María Veronica; Blanco, Federico Carlos; Nuñez, Javier; Klepp, Laura Ines; Vazquez, Cristina Lourdes; Santangelo, María De La Paz; Rocha, Rosana Valeria; Soria, Marcelo; Golby, Paul; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (BMC, 2013-09)
      Background: Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called ...

    • Tuberculosis vaccine candidates based on mycobacterial cell envelope components 

      Sarmiento, María E.; Alvarez, N.; Chin, K.L.; Bigi, Fabiana; Tirado Hernández, Yanely; García, M.A.; Anis, F.Z.; Norazmi, Mohd Nor; Acosta, Armando (Elsevier, 2019-03)
      Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). ...

    • Virulence factors of the Mycobacterium tuberculosis complex 

      Forrellad, Marina Andrea; Klepp, Laura Ines; Gioffre, Andrea; Sabio y Garcia, Julia Veronica; Morbidoni, Hector R.; Santangelo, María De La Paz; Cataldi, Angel Adrian; Bigi, Fabiana (Taylor & Francis, 2013-01)
      The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and ...