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Babesia bovis AMA-1, MSA-2c and RAP-1 contain conserved B and T-cell epitopes, which generate neutralizing antibodies and a long-lasting Th1 immune response in vaccinated cattle
(Elsevier, 2022-02)Vaccines against bovine babesiosis must, ideally, induce a humoral immune response characterized by neutralizing antibodies against conserved epitopes and a cellular Th1 immune response. In Babesia bovis, proteins such as ... -
Babesia bovis biological clones and the inter-strain allelic diversity of the Bv80 gene support subpopulation selection as a mechanism involved in the attenuation of two virulent isolates
(Elsevier, 2012-12-21)The virulence phenotype of Babesia bovis subpopulations was evaluated using biological clones derived from the high-virulence BboS2P and the low-virulence BboR1A strain and two original virulent isolates, BboL15 and BboL17, ... -
Biochemical characterization of thioredoxin reductase from Babesia bovis
(2014-04)This paper addresses the identification, cloning, expression, purification and functional characterization of thioredoxin reductase from Babesia bovis, the etiological agent of babesiosis. The work deals with in vitro ... -
Casos de anaplasmosis, babesiosis y tripanosomiasis bovina registradas en el INTA Rafaela (2012-2019)
(Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste, 2022-06)Anaplasmosis, babesiosis y tripanosomiasis de los bovinos son enfermedades de importancia económica provocadas por Anaplasma marginale, Babesia bovis y/o Babesia bigemina, y Trypanosoma vivax, respectivamente. En este ... -
Comparative Degradome Analysis of the Bovine Piroplasmid Pathogens Babesia bovis and Theileria annulata
(MDPI, 2023-02)Babesia bovis and Theileria annulata are tick-borne hemoprotozoans that impact bovine health and are responsible for considerable fatalities in tropical and subtropical regions around the world. Both pathogens infect the ... -
Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuation
(2013-11)Background: Loss of virulence is a phenotypic adaptation commonly seen in prokaryotic and eukaryotic pathogens. This mechanism is not well studied, especially in organisms with multiple host and life cycle stages such as ... -
Desarrollo de candidatos vacunales contra Babesia bovis basados en vectores virales y proteínas recombinantes
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2016-09)La babesiosis bovina es una enfermedad parasitaria trasmitida por garrapatas y causada por los protozooarios intraeritrocíticos Babesia bovis y B. bigemina. Esta infección provoca importantes pérdidas económicas en varias ... -
Descripción de dos brotes de babesiosis nerviosa (Babesia bovis) en bovinos de la prepuna de Jujuy, Argentina.
(Editorial Veterinaria Argentina, 2017-07)Se describen los aspectos epidemiológicos y clínicopatológicos de dos brotes de babesiosis nerviosa en la región prepuna de la provincia de Jujuy, zona desfavorable para el establecimiento de Rhipicephalus (Boophilus) ... -
Descripción de dos casos de babesiosis cerebral en terneros de hasta 15 días de edad
(Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, 2020-06)La babesiosis es una enfermedad causada por Babesia bovis y Babesia bigemina, integrante del complejo conocido como “Tristeza bovina” y relevante en el Noroeste argentino (NOA). La presentación clínica de esta enfermedad ... -
Development of highly sensitive one step-PCR tests for improved detection of B. bigemina and B. bovis
(Elsevier, 2021-08)Bovine babesiosis caused by Babesia bigemina and B. bovis is an economically relevant tick-borne disease distributed over tropical and subtropical world regions. Animals that recover from the clinical disease can remain ... -
Estudio de la diversidad genética en poblaciones de Babesia bigemina de diferentes regiones geográficas
(Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 2013)La babesiosis bovina es una enfermedad enzoótica causada por protozoarios Apicomplexa del género Babesia. En Argentina, esta enfermedad es provocada por B. bovis y B. bigemina, ambas trasmitidas por la garrapata Rhipicephalus ... -
Estudio prospectivo de las primo infecciones por Babesia bovis en terneros Brahman y Brangus de un área enzoótica de Corrientes, Argentina
(2014)Se evaluaron primo-infecciones causadas por Babesia bovis en terneros Brahman y Brangus en zona endémica de Corrientes, mediante la detección de: anticuerpos por ELISA-i, hematocrito y parasitemia en 48 vacas ... -
Highly sensitive nested PCR and rapid immunochromatographic detection of Babesia bovis and Babesia bigemina infection in a cattle herd with acute clinical and fatal cases in Argentina
(Wiley, 2020-07)Bovine babesiosis is a tick‐transmitted haemoparasitic disease caused by Babesia bovis and B. bigemina affecting cattle of tropical and subtropical regions around the world. Pathogens are transmitted by the tick vector ... -
Immunisation of cattle against Babesia bovis combining a multi-epitope modified vaccinia Ankara virus and a recombinant protein induce strong Th1 cell responses but fails to trigger neutralising antibodies required for protection
(Elsevier, 2019-10)Protection against the intraerythrocytic protozoan parasite Babesia bovis depends on both strong innate and adaptive immune response, this latter involving the presentation of parasite antigens to CD4+ T-lymphocytes by ... -
International interlaboratory validation of a nested PCR for molecular detection of Babesia bovis and Babesia bigemina, causative agents of bovine babesiosis
(Elsevier, 2022-04)Babesia bovis and B. bigemina are tick-transmitted parasites causing bovine babesiosis, characterized by significant morbidity and mortality leading to economic losses to the livestock industry in tropical and subtropical ... -
Kinetic characterization of a novel cysteine peptidase from the protozoan Babesia bovis, a potential target for drug design
(Elsevier, 2020-12)C1A cysteine peptidases have been shown to play an important role during apicomplexan invasion and egress of host red blood cells (RBCs) and therefore have been exploited as targets for drug development, in which peptidase ... -
Mitigated clinical disease in water buffaloes experimentally infected with Babesia bovis
(2018-07)Water buffaloes (Bubalus bubalis) are raised in tropical and subtropical regions of the world, and act as hosts of Babesia bovis parasites and the tick vector Rhipicephalus microplus. As no clinical cases of B. bovis-infection ... -
Novel biotechnological platform based on baculovirus occlusion bodies carrying Babesia bovis small antigenic peptides for the design of a diagnostic enzyme-linked immunosorbent assay (ELISA)
(Springer, 2018-01)Baculoviruses are large DNA virus of insects principally employed in recombinant protein expression. Its ability to form occlusion bodies (OBs), which are composed mainly of polyhedrin protein (POLH), makes them ... -
Risks of cattle babesiosis (Babesia bovis) outbreaks in a semi-arid region of Argentina
(Elsevier, 2019-10)The epidemiology of Babesia bovis was studied in terms of enzootic stability/instability and husbandry and abiotic factors influencing B. bovis transmission rate in northeastern Santiago del Estero province, Argentina. The ... -
The key to egress? Babesia bovis perforin-like protein 1 (PLP1) with hemolytic capacity is required for blood stage replication and is involved in the exit of the parasite from the host cell
(Elsevier, 2021-07)Bovine babesiosis is a tick-borne disease caused by apicomplexan parasites of the Babesia genus that represents a major constraint to livestock production worldwide. Currently available vaccines are based on live parasites ...