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BLV: lessons on vaccine development
Abdala, Alejandro Ariel; Alvarez, Irene; Brossel, Hélène; Calvinho, Luis Fernando; Carignano, Hugo; Franco, Lautaro Nahuel; Gazon, Hélène; Gillissen, Christelle; Hamaidia, Malik; Hoyos, Clotilde; Jacques, Jean-Rock; Joris, Thomas; Laval, Florent; Petersen, Marcos Iván; Porquet, Florent; Porta, Natalia Gabriela; Ruiz, Vanesa; Safari, Rogaiyeh; Suarez Archilla, Guillermo Alejandro; Trono, Karina Gabriela; Willems, Luc (BMC, 2019-10-07)Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since ... -
Bovine leukemia virus encoded blv-miR-b4-3p microRNA is associated with reduced expression of anti-oncogenic gene in vivo
Petersen, Marcos Iván; Carignano, Hugo Adrian; Mongini, Claudia; Gonzalez, Diego D.; Jaworski, Juan Pablo (PLOS, 2023-02)Bovine leukemia virus (BLV) is a retrovirus that causes malignant B-cell lymphoma in up to ten-percent of infected cattle. To date, the mechanisms of BLV linked to malignant transformation remain elusive. Although BLV-encoded ... -
Development of a droplet digital PCR assay for quantification of the proviral load of bovine leukemia virus
De Brun, María L.; Cosme, Bruno; Petersen, Marcos Iván; Alvarez, Irene; Folgueras-Flatschart, Aurea; Flatschart, Roberto; Panei, Carlos Javier; Puentes, Rodrigo (Sage Publications, 2022-05)Droplet digital PCR (ddPCR) is a highly sensitive tool developed for the detection and quantification of short-sequence variants—a tool that offers unparalleled precision enabling measurement of smaller-fold changes. We ... -
Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition
Pereyra, Walter Rodrigo; Mansilla, Florencia Celeste; Petersen, Marcos Iván; Suarez, Victor Humberto; Capozzo, Alejandra Victoria (Elsevier, 2019-02)Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information ... -
Expression-based analysis of genes related to single nucleotide polymorphism hits associated with bovine leukemia virus proviral load in Argentinean dairy cattle
Petersen, Marcos Iván; Carignano, Hugo Adrian; Suarez Archilla, Guillermo; Caffaro, María Eugenia; Alvarez, Irene; Miretti, Marcos Mateo; Trono, Karina Gabriela (Elsevier, 2021-02)In dairy cattle infected with bovine leukemia virus (BLV), the proviral load (PVL) level is directly related to the viral transmission from infected animals to their healthy herdmates. Two contrasting phenotypic groups can ... -
Seroprevalencia de leucosis enzoótica bovina en tambos del sur de la provincia de Córdoba, Argentina = Seroprevalence of enzootic bovine leucosis in dairy farms in the south of the province of Córdoba, Argentina
Mació, M.; Magnano, Gabriel; Porta, Natalia Gabriela; Petersen, Marcos Iván; Macias, Analía; Sticotti, E.; Ruiz, Vanesa; Schneider, M.; Giraudo, J. (2019-03)La Leucosis Enzoótica Bovina (LEB) afecta al tejido linfoide y el rasgo patológico distintivo es la transformación neoplásica de linfocitos B, su frecuencia es predominante en el ganado lechero adulto. Existen pocos estudios ... -
Spontaneous virus reactivation in cattle chronically infected with bovine leukemia virus
Jaworski, Juan Pablo; Petersen, Marcos Iván; Carignano, Hugo; Trono, Karina Gabriela (BioMed Central, 2019)Background: The absence of virus expression during the chronic stage of bovine leukemia virus (BLV) infection and its reactivation upon ex vivo culture has become a long-lived Dogma. During the chronic stage of BLV ...