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Mostrando ítems 1-20 de 36
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A β-Hairpin Motif in the Envelope Protein E2 Mediates Receptor Binding of Bovine Viral Diarrhea Virus
Merwaiss, Fernando; Pascual, María José; Pomilio, María Trinidad; Lopez, Maria Gabriela; Taboga, Oscar Alberto; Alvarez, Diego Ezequiel (MDPI, 2021-06)Pestivirus envelope protein E2 is crucial to virus infection and accomplishes virus-receptor interaction during entry. However, mapping of E2 residues mediating these interactions has remained unexplored. In this study, ... -
AcMNPV Core Gene ac109 Is Required for Budded Virion Transport to the Nucleus and for Occlusion of Viral Progeny
Alfonso, Victoria; Maroniche, Guillermo Andrés; Reca, Sol Rita; Lopez, Maria Gabriela; Del Vas, Mariana; Taboga, Oscar Alberto (Plos One, 2012-09)The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac109 core gene has been previously characterized as an essential late gene. Our results showed that budded virions could be detected in supernatants of ... -
Allelic differences in a vacuolar invertase affect Arabidopsis growth at early plant development
Coluccio Leskow, Carla; Dominguez, Pia Guadalupe; Díaz Zirpolo, José Antonio; Obata, Toshihiro; Kamenetzky, Laura; Costa, Hernán; Taboga, Oscar Alberto; Marti, Hector Ruben; Keurentjes, Joost; Sulpice, Ronan; Ishihara, Hirofumi; Stitt, Mark; Fernie, Alisdair R.; Carrari, Fernando (2016)Improving carbon fixation in order to enhance crop yield is a major goal in plant sciences. By quantitative trait locus (QTL) mapping, it has been demonstrated that a vacuolar invertase (vac-Inv) plays a key role in ... -
Artificial microRNAs as antiviral strategy to FMDV: structural implications of target selection
Gismondi, Maria Ines; Ortiz, Xoana P.; Curra, Anabella Paola; Asurmendi, Sebastian; Taboga, Oscar Alberto (2014-04)RNA interference (RNAi) appears as a promising strategy to control virus replication. While the antiviral power of short-hairpin RNAs or small-interfering RNAs against FMDV has been demonstrated widely, safer RNAi effectors ... -
Assessing Tn5 and sleeping beauty for transpositional transgenesis by cytoplasmic injection into bovine and ovine zygotes
Bevacqua, Romina Jimena; Fernández y Martin, Rafael; Canel, Natalia Gabriela; Gibbons, Alejandro Eduardo; Texeira, D.I.A.; Lange, F.; Vans Landschoot, Geraldina; Savy, Virginia; Briski, Olinda; Hiriart, María Inés; Grueso, Esther; Ivics, Zoltán; Taboga, Oscar Alberto; Kues, Wilfried A.; Ferraris, S.R.; Salamone, Daniel Felipe (2017-03-16)Transgenic domestic animals represent an alternative to bioreactors for large-scale production of biopharmaceuticals and could also provide more accurate biomedical models than rodents. However, their generation remains ... -
Baculovirus AcMNPV induces type I interferons and NK/NKT cells-mediated protection against foot-and-mouth disease virus in mice
Molina, Guido Nicolas; Cacciabue, Marco Polo; Gismondi, Maria Ines; Taboga, Oscar Alberto; Molinari, Maria Paula (Elsevier, 2020-08)Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately ... -
Baculovirus capsid display in vaccination schemes: effect of a previous immunity against the vector on the cytotoxic response to delivered antigens
Molinari, Maria Paula; Molina, Guido Nicolás; Tavarone, Maria Eugenia; Del Medico Zajac, Maria Paula; Moron, Victor Gabriel; Taboga, Oscar Alberto (Springer, 2018-12)The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, although it also has been used as display vector for vaccine development. In this ... -
Baculovirus transduction in mammalian cells is affected by the production of type I and III interferons, which is mediated mainly by the cGAS-STING pathway
Amalfi, Sabrina; Molina, Guido Nicolas; Bevacqua, Romina Jimena; Lopez, Maria Gabriela; Taboga, Oscar Alberto; Alfonso, Victoria (American Society for Microbiology, 2020-11)The baculovirus Autographa californica multiple nucleopolyhedrovirus is an insect virus with a circular double-stranded DNA genome, which, among other multiple biotechnological applications, is used as an expression vector ... -
Baculovirus vectors induce the production of interferons in swine : their potential in the development of antiviral strategies
Molina, Guido Nicolas; Amalfi, Sabrina; Otero, Ignacio; Taboga, Oscar Alberto; Molinari, Maria Paula (MDPI, 2021-11)The huge variety of viruses affecting swine represents a global threat. Since vaccines against highly contagious viruses last several days to induce protective immune responses, antiviral strategies for rapid control of ... -
Biotechnological applications of occlusion bodies of Baculoviruses
Lopez, Maria Gabriela; Diez, Michay; Alfonso, Victoria; Taboga, Oscar Alberto (Springer, 2018-08)The ability of Baculoviruses to hyper-express very late genes as polyhedrin, the major component of occlusion bodies (OBs) or polyhedra, has allowed the evolution of a system of great utility for biotechnology. The main ... -
Canarypox virus expressing infectious bursal disease VP2 protein as immunogen for chickens
Zanetti, Flavia Adriana; Conte Grand, María Daniela; Mitarotonda, Romina Cristina; Taboga, Oscar Alberto; Calamante, Gabriela (Sociedade Brasileira de Microbiologia, 2014-05)Canarypox viruses (CNPV) carrying the coding sequence of VP2 protein from infectious bursal disease virus (IBDV) were obtained. These viruses were able to express VP2 protein in vitro and to induce IBDV-neutralizing ... -
Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
Quattrocchi, Valeria; Molinari, Maria Paula; Langellotti, Cecilia Ana; Gnazzo, Victoria; Taboga, Oscar Alberto; Zamorano, Patricia Ines (Elsevier, 2013-05-31)Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were ... -
Comparison of internal process control viruses for detection of food and waterborne viruses
Blanco Fernández, María Dolores; Barrios, Melina Elizabeth; Cammarata, Robertina Viviana; Torres, Carolina; Taboga, Oscar Alberto; Mbayed, Viviana Andrea (2017-05)Enteric viruses are pathogens associated with foodand waterborne outbreaks. The recovery of viruses from food or water samples is affected by the procedures applied to detect and concentrate them. The incorporation of an ... -
Development and biological evaluation of pNIPAM-based nanogels as vaccine carriers
Soriano Perez, María Laura; Funes, Javier Alejandro; Flores Bracamonte, Carolina; Ibarra, Luis Exequiel; Forrellad, Marina Andrea; Taboga, Oscar Alberto; Cariddi, Laura Noelia; Salinas, Facundo José; Ortega, Hugo Héctor; Alustiza, Fabrisio Eduardo; Molina, Maria (Elsevier, 2023-01)“Smart” nanogels are an attractive tool for the development of new strategies of immunization in veterinary medicine. Here, we reported the synthesis and physicochemical characterization of thermoresponsive nanogels based ... -
Development of a novel set of Gateway-compatible vectors for live imaging in insect cells
Maroniche, Guillermo Andrés; Mongelli, Vanesa Claudia; Alfonso, Victoria; Llauger, Gabriela; Taboga, Oscar Alberto; Del Vas, Mariana (The Royal Entomological Society, 2011-10)Insect genomics is a growing area of research. To exploit fully the genomic data that are being generated, high-throughput systems for the functional characterization of insect proteins and their interactomes are required. ... -
Double-layered rotavirus-like particles are efficient carriers to elicit strong CTL responses to delivered heterologous antigens
Molinari, Maria Paula; Peralta, Andrea Veronica; Maletto, Belkys Angélica; Pistoresi Palencia, Maria Cristina; Crespo, Maria Ines; Moron, Victor Gabriel; Taboga, Oscar Alberto (Elsevier, 2014-11)The first 92 amino acids of VP2 of rotavirus are dispensable for VLP assembly and can be replaced by heterologous reporter proteins without affecting either self-assembly of chimeric VP2 or the interaction with VP6 to ... -
Effects of deletion of the ac109 gene of Autographa californica nucleopolyhedrovirus on interactions with mammalian cells
Alfonso, Victoria; Amalfi, Sabrina; Lopez, Maria Gabriela; Taboga, Oscar Alberto (2017-03)Baculoviruses are able to enter into mammalian cells, where they can express a transgene that is placed under an appropriate promoter, without producing infectious progeny. ORF109 encodes an essential baculovirus protein ... -
Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system
Bevacqua, Romina Jimena; Fernandez-Martín, R.; Savy, Virginia; Canel, Natalia Gabriela; Gismondi, Maria Ines; Kues, Wilfried A.; Carlson, Daniel F.; Fahrenkrug, S.C.; Niemann, H.; Taboga, Oscar Alberto; Ferraris, Sergio; Salamone, Daniel Felipe (2016-11)The recently developed engineered nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated nuclease ... -
Expresión de antígenos derivados del virus de la fiebre aftosa en diferentes sistemas eucarióticos
Taboga, Oscar Alberto (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2000)La fiebre aftosa es una enfermedad de gran importancia económica que afecta principalmente al ganado bovino. Esta enfermedad está causada por un picornavirus, el virus de la fiebre aftosa (VFA). El control de la enfermedad ... -
Expression and purification of recombinant feline interferon in the baculovirus-insect larvae system
Targovnik, Alexandra Marisa; Villaverde, Marcela Solange; Arregui, Mariana Bernadett; Fogar, Mariela Noemi; Taboga, Oscar Alberto; Glikin, Gerardo Claudio; Finocchiaro, Liliana Maria Elena; Cascone, Osvaldo; Miranda, Maria Victoria (2014-06)Feline interferons (FeIFNs) are cytokines with antiviral, antitumor and immunomodulatory functions used as therapeutic agents in a variety of veterinary diseases. In this work, FeIFN-α7 and FeIFN-α7xArg containing eight ...