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MVAΔ008 viral vector encoding the model protein OVA induces improved immune response against the heterologous antigen and equal levels of protection in a mice tumor model than the conventional MVA
(Elsevier, 2021-11)Modified vaccinia Ankara virus (MVA) is extensively used as a vaccine vector. We have previously observed that MVAΔ008, an MVA lacking the gene that codes for interleukin-18 binding protein, significantly increases CD8+ ... -
Neospora caninum truncated recombinant proteins formulated with liposomes and CpG-ODNs triggered a humoral immune response in cattle after immunisation and challenge
(Elsevier, 2021-06)Abortions caused by Neospora caninum are a serious problem in cattle production and require effective immunoprophylaxis. The objective of this work was to assess the humoral immune response to four recombinant (r) N. caninum ... -
New scenarios for brucella suis and brucella melitensis
(Springer, 2017-03)Purpose of Review: We pretend to highlight the most important advances reached in the last few years in the biology of Brucella suis and Brucella melitensis and focus attention on new tools for the comprehension, prevention ... -
Next-generation technologies and systems biology for the design of novel vaccines against apicomplexan parasites
(Frontiers Media, 2022-01)Parasites of the phylum Apicomplexa are the causative agents of important diseases such as malaria, toxoplasmosis or cryptosporidiosis in humans, and babesiosis and coccidiosis in animals. Whereas the first human recombinant ... -
Novel expression of immunogenic foot-and-mouth disease virus-like particles in Nicotiana benthamiana
(2018-01)Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals and is endemic in Africa, parts of South America and southern Asia. The causative agent, FMD virus (FMDV) is a member of the genus ... -
Obtención de mutantes de Brucella abortus genéticamente definidas: su caracteización molecular y evaluación de su uso como vacunas para la brucelosis bovina
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2017)El desarrollo de las técnicas de ADN recombinante permitió la generación de vacunas racionalmente diseñadas. Teniendo esto en cuenta, el objetivo de este trabajo es la obtención de cepas de Brucella abortus genéticamente ... -
Plant-based vaccine candidate against Infectious bursal disease: an alternative to inactivated vaccines for breeder hens
(Elsevier, 2019-08)Infectious bursal disease (IBD) is an acute, highly contagious immunosuppressive disease that affects young birds causing important economic losses in the poultry industry worldwide. Strict hygiene management together with ... -
Plant-based vaccine for livestock : key points to unleash platform translation in developing countries
(2016-12)Ten years ago the first plant-based vaccine was licensed (DowAgrosciences). It was only 20 years after the first report of a recombinant protein obtained through plant transformation technology. Back then, this vaccine was ... -
Plant‐produced viral bovine vaccines: what happened during the last 10 years?
(Wiley, 2015-10)Vaccination has proved to be an efficient strategy to deal with viral infections in both human and animal species. However, protection of cattle against viral infections is still a major concern in veterinary science. ... -
Preparation and characterization of a Staphylococcus aureus capsular polysaccharide-protein conjugate prepared by a low cost technique: a proof-of-concept study
(2015-01)Staphylococcus aureus is a worldwide distributed pathogen that produces several diseases in many species and is the major cause of mastitis in dairy cows. S. aureus capsular polysaccharide 5 (CP5) has been widely proposed ... -
Producción y evaluación de antígenos recombinantes para el diagnóstico serológico y la generación de vacunas para el control de la anaplasmosis bovina
(Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, 2020)La anaplasmosis bovina, causada por Anaplasma marginale (rickettsia intraeritrocítica transmitida por artrópodos hematófagos), es una enfermedad infecciosa de gran interés por las severas pérdidas económicas que ocasiona. ... -
Producción y evaluación de antígenos recombinantes para el diagnóstico serológico y la generación de vacunas para el control de la anaplasmosis bovina
(Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, 2020)En este trabajo se abordó la anaplasmosis de forma integral, desde el diagnóstico y la prevención. La evaluación serológica de la enfermedad se realiza por ELISA de competición (ELISAc), utilizando como antígeno a la ... -
Protection efficacy of Argentinian isolates of Mycobacterium avium subsp. paratuberculosis with different genotypes and virulence in a murine model
(Elsevier, 2018-12)Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include ... -
Protection induced by a glycoprotein E-deleted bovine herpesvirus type 1 marker strain used either as an inactivated or live attenuated vaccine in cattle
(BMC, 2014-01)Background: Bovine herpesvirus type 1 (BoHV-1) is the causative agent of respiratory and genital tract infections; causing a high economic loss in all continents. Use of marker vaccines in IBR eradication programs is widely ... -
Recent advances in BLV research
(MDPI, 2015-11)Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and ... -
A recombinant multi-antigen vaccine formulation containing Babesia bovis merozoite surface antigens MSA-2a1, MSA- 2b and MSA-2c elicits invasion-inhibitory antibodies and IFN-γ producing cells
(2016)Background: Babesia bovis is a tick-transmitted protozoan hemoparasite and the causative agent of bovine babesiosis, a potential risk to more than 500 million cattle worldwide. The vaccines currently available are based ... -
Respuesta inmune en caprinos criollos vacunados con la vacuna Brucella melitensis REV 1 aplicada por vía conjuntival
(Sociedad de Medicina Veterinaria (SOMEVE) de la Republica Argentina, 2020-03)Se evaluó la respuesta inmune humoral producida por la vacuna Brucella melitensis REV 1 conjuntival en caprinos criollos. Se utilizaron 11 caprinos adultos divididos en 3 grupos: G1 (5 hembras) y G2 (3 machos) que fueron ... -
Reverse Vaccinology approach for antigen candidates prioritization to develop a vaccine against a poultry pathogen
(Sociedad Argentina de Investigación Clínica, 2022-11)Avibacterium paragallinarum (AvP) is the causative agent of infectious coryza, an acute disease that affects the upper respiratory system of chickens. This Gram-negative pathogen is widely distributed in poultry production ... -
Roedores, bovinos y matemáticas
(Gerencia de Comunicación e Imagen Institucional, DNA SICC, INTA, 2013-08)Un modelo estadístico que desarrolló y validó el INTA para estudiar la calidad de las vacunas bovinas será utilizado como control oficial por el SENASA. Podría ser recomendado para su implementación en el resto de América -
Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
(2016-08)An oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama ...