Now showing items 1-20 of 31

    • A phenotypic characterization of two isolates of a multidrug-resistant outbreak strain of mycobacterium tuberculosis with opposite epidemiological fitness 

      Bei, Jinlong; Bigi, María Mercedes; Lima, Analía; Zhang, Qi; Blanco, Federico Carlos; López, Beatriz; Yu, Ting; Wang, Zhilin; Dai, Zhangyan; Chen, Zhuang; Cataldi, Angel Adrian; Sasiain, María del Carmen; Ritacco, Viviana; De la Barrera, Silvia Susana; Soria, Marcelo Abel; Durán, Rosario; Bigi, Fabiana (Hindawi, 2020-04)
      Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB ...
    • Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles 

      Bigi, María Mercedes; Vazquez, Cristina Lourdes; Castelão, Ana Beatriz C.; Garcia, Elizabeth Andrea; Cataldi, Angel Adrian; Jackson, Mary; McNeil, Michael; Soria, Marcelo Abel; Zumarraga, Martin Jose; Cabruja, Matias; Gago, Gabriela; Blanco, Federico Carlos; Nishibe, Christiane; Almeida Junior, Nalvo Franco de; Araujo, Flabio Ribeiro de; Bigi, Fabiana (Elsevier, 2019-12)
      Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic ...
    • Characterization of the two component regulatory system PhoPR in Mycobacterium bovis 

      Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, María Mercedes; Vazquez, Cristina Lourdes; Forrellad, Marina Andrea; Rocha, Rosana Valeria; Golby, Paul; Soria, Marcelo Abel; Bigi, Fabiana (Elsevier, 2018-08)
      Mycobacterium bovis is the causative agent of bovine tuberculosis and is a member of Mycobacterium tuberculosis complex, which causes tuberculosis in a number of mammals including humans. Previous studies have shown that ...
    • Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? 

      Sabio Y Garcia, Julia Veronica; Bigi, María Mercedes; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, Fabiana (Elsevier, 2020-08)
      Members of the Mycobacterium tuberculosis complex (MTBC) are responsible for tuberculosis in several mammals. In this complex, Mycobacterium tuberculosis and Mycobacterium bovis, which are closely related, show host ...
    • Draft genome sequence of Mycobacterium bovis 04-303, a highly virulent strain from Argentina 

      Nishibe, Christiane; Canevari Castelão, Ana Beatriz; Dalla Costa, Ricardo; Pinto, Beatriz Jeronimo; Varuzza, Leonardo; Cataldi, Angel Adrian; Bernardelli, Amelia; Bigi, Fabiana; Blanco, Federico Carlos; Zumarraga, Martin Jose; Almeida, Nalvo Franco; Araujo, Flabio Ribeiro de (American Society for Microbiology, 2013-11)
      Mycobacterium bovis strain 04-303 was isolated from a wild boar living in a free-ranging field in Argentina. This work reports the draft genome sequence of this highly virulent strain and the genomic comparison of its major ...
    • ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis 

      Blanco, Federico Carlos; Soria, Marcelo Abel; Klepp, Laura Ines; Bigi, Fabiana (Karger, 2017-12)
      Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses ...
    • Experimental selection of long‐term intracellular mycobacteria 

      Vazquez, Cristina Lourdes; Lerner, Thomas R.; Kasmapour, Bahram; Pei, Gang; Gronow, Achim; Bianco, María Veronica; Blanco, Federico Carlos; Bleck, Christopher K.E.; Geffers, Robert; Bigi, Fabiana; Abraham, Wolf-Rainer; Gutierrez, Maximiliano Gabriel (Wiley, 2014-09)
      Some intracellular bacteria are known to cause long‐term infections that last decades without compromising the viability of the host. Although of critical importance, the adaptations that intracellular bacteria undergo ...
    • FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis 

      Mondino, Sonia; Vazquez, Cristina Lourdes; Cabruja, Matias; Sala, Claudia; Cazenave-Gassiot, Amaury; Blanco, Federico Carlos; Wenk, Markus R.; Bigi, Fabiana; Cole, Stewart T.; Gramajo, Hugo; Gago, Gabriela (Frontiers Media, 2020-10)
      Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is the world’s leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition ...
    • La genómica de las micobacterias 

      Viale, Mariana; Zumarraga, Martin Jose; Araujo, Flabio Ribeiro de; Zarraga, Ana Maria; Cataldi, Angel Adrian; Romano, Maria Isabel; Bigi, Fabiana (Office International des Epizooties, 2016)
      Las especies Mycobacterium bovis y Mycobacterium avium subsp. paratuberculosis son los agentes causales de la tuberculosis y la paratuberculosis en animales, respectivamente. Además, ambas micobacterias, pero fundamentalmente ...
    • Identification and evaluation of new Mycobacterium bovis antigens in the in vitro interferon gamma release assay for bovine tuberculosis diagnosis 

      Eirin, Maria Emilia; Macías, Analía; Magnano, Gabriel; Morsella, Claudia Graciela; Mendez, Laura Luján; Blanco, Federico Carlos; Bianco, María Veronica; Severina, Walter; Alito, Alicia Elsa; Pando, Maria de los Angeles; Singh, Mahavir G.; Spallek, Ralph; Paolicchi, Fernando; Bigi, Fabiana; Cataldi, Angel Adrian (Elsevier, 2015-12)
      Bovine tuberculosis (bTB) is a common zoonotic disease, caused by Mycobacterium bovis (M. bovis), responsible for significant economic losses worldwide. Its diagnosis is based on the detection of cell mediated immunity ...
    • Identification of bovine tuberculosis biomarkers to detect tuberculin skin test and IFNγ release assay false negative cattle 

      Klepp, Laura Ines; Eirin, Maria Emilia; Garbaccio, Sergio Gabriel; Soria, Marcelo Abel; Bigi, Fabiana; Blanco, Federico Carlos (Elsevier, 2019-02)
      Bovine tuberculosis (bTB) is an important animal and zoonotic disease, which causes severe economic losses. The main focus of this study was to assess the predictive power of previously identified biomarkers of bTB in ...
    • Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG 

      Carroll, Maria V.; Sim, Robert B.; Bigi, Fabiana; Jäkel, Anne; Antrobus, Robin; Mitchell, Daniel A. (Springer, 2010-09)
      Dendritic-cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN; CD209) has an important role in mediating adherence of Mycobacteria species, including M. tuberculosis and M. bovis BCG to human ...
    • IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis 

      Rovetta, Ana Inés; Peña, Delfina; Hernández del Pino, Rodrigo Emanuel; Recalde, Gabriela María; Pellegrini, Joaquín Miguel; Bigi, Fabiana; Musella, Rosa María; Palmero, Domingo; Gutierrez, Marisa; Colombo, Maria Isabel; García, Verónica Edith (Taylor & Francis, 2014-11)
      Protective immunity against Mycobacterium tuberculosis (Mtb) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent Mtb in macrophage cell lines. We investigated the contribution of ...
    • Klebsiella pneumoniae ST258 negatively regulates the oxidative burst in human neutrophils 

      Castillo, Luis A.; Birnberg-Weiss, Federico; Rodriguez-Rodrigues, Nahuel; Martire-Greco, Daiana; Bigi, Fabiana; Landoni, Veronica I.; Gomez, Sonia A.; Fernandez, Gabriela C. (Frontiers Media, 2019-04)
      The epidemic clone of Klebsiella pneumoniae (Kpn), sequence type 258 (ST258), carbapenamase producer (KPC), commonly infects hospitalized patients that are left with scarce therapeutic option since carbapenems are last ...
    • Metabolic profile of mycobacterium smegmatis reveals Mce4 proteins are relevant for cell wall lipid homeostasis 

      Santangelo, María De La Paz; Heuberger, Adam; Blanco, Federico Carlos; Forrellad, Marina Andrea; Taibo, Catalina Beatriz; Klepp, Laura Ines; Sabio y Garcia, Julia Veronica; Nikel, Pablo I.; Jackson, Mary; Bigi, Fabiana (2016)
      Introduction The Mce proteins are encoded in a variable number of operons (from one to eight) in all Mycobacterium species. A role in the transport of host and mycobacterial lipids has been demonstrated for some Mce proteins ...
    • Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis 

      Garcia, Elizabeth Andrea; Bianco, Marí­a Veronica; Blanco, Federico Carlos; Bigi, Fabiana (2016)
      Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether ...
    • Mycobacterium bovis Dmce2 double deletion mutant protects cattle against challenge with virulent M. bovis 

      Blanco, Federico Carlos; Bianco, María Veronica; Garbaccio, Sergio Gabriel; Meikle, Virginia; Gravisaco, María José; Montenegro, Valeria Noely; Alfonseca, Edgar; Singh, Mahavir G.; Barandiaran, Soledad; Canal, Ana María; Vagnoni, Lucas Emilio; Buddle, Bryce Malcom; Bigi, Fabiana; Cataldi, Angel Adrian (Elsevier, 2013-05)
      A Mycobacterium bovis strain deleted in mce2A and mce2B genes (M. bovis Δmce2) was tested as an experimental vaccine in cattle challenged with a virulent M. bovis strain. Three-and-a-half-month old calves (n = 5 to 6 per ...
    • Mycobacterium bovis ESAT-6, CFP-10 and EspC antigens show high conservation among field isolates 

      Encinas, Micaela; Marfil, Maria Jimena; Garbaccio, Sergio Gabriel; Barandiaran, Soledad; Huertas, Pablo Sebastian; Morsella, Claudia Graciela; Macias, Analía; Magnano, Gabriel; Zapata, L.; Bigi, Fabiana; Cataldi, Angel Adrian; Paolicchi, Fernando; Zumarraga, Martin Jose; Eirin, Maria Emilia (Elsevier, 2018-07)
      ESAT-6, CFP-10 and EspC are virulence factors that have been extensively assayed for bovine and human tuberculosis diagnosis due their potent T-cell inducing activities. While polymorphisms of ESAT-6 and CFP-10 were analyzed, ...
    • Mycobacterium bovis requires P27 (LprG) to arrest phagosome maturation and replicate within bovine macrophages 

      Vazquez, Cristina Lourdes; Bianco, María Veronica; Blanco, Federico Carlos; Forrellad, Marina Andrea; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (2017-03)
      Mycobacterium bovis causes tuberculosis in a wide variety of mammals, with strong tropism for cattle and eventually humans. P27, also called LprG, is among the proteins involved in the mechanisms of the virulence and ...
    • Patterns and processes of mycobacterium bovis evolution revealed by phylogenomic analyses 

      Patané, José S. L.; Martins Jr, Joaquim; Castelão, Ana Beatriz C.; Nishibe, Christiane; Montera, Luciana; Bigi, Fabiana; Zumarraga, Martin Jose; Cataldi, Angel Adrian; Fonseca Junior, Antônio; Roxo, Eliana; Osório, Ana Luiza Alves Rosa; Jorge, Klaudia dos Santos Goncalves; Thacker, Tyler C.; Almeida, Nalvo F.; Araujo, Flabio Ribeiro de; Setubal, Joâo C. (Oxford University Press, 2017-03)
      Mycobacterium bovis is an important animal pathogen worldwide that parasitizes wild and domesticated vertebrate livestock as well as humans. A comparison of the five M. bovis complete genomes from the United Kingdom, South ...