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Mostrando ítems 1-12 de 12
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A new cage-like particle adjuvant enhances protection of foot-and-mouth disease vaccine
Bidart, Juan Esteban; Kornuta, Claudia Alejandra; Gammella, Mariela; Gnazzo, Victoria; Soria, Ivana; Langellotti, Cecilia Ana; Mongini, Claudia; Galarza, Roxana Ivon; Calvinho, Luis Fernando; Lupi, Giuliana; Quattrocchi, Valeria; Marcipar, Ivan; Zamorano, Patricia Ines (Frontiers Media, 2020-07)Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model ... -
A plasmid encoding the extracellular domain of CD40 ligand and MontanideTM GEL01 as adjuvants enhance the immunogenicity and the protection induced by a DNA vaccine against BoHV-1
Kornuta, Claudia Alejandra; Langellotti, Cecilia Ana; Bidart, , Juan Esteban; Soria, Ivana; Quattrocchi, Valeria; Gammella, Mariela; Cheuquepan Valenzuela, Felipe; Mignaqui, Ana Clara; Ferraris, Sergio; Charleston, Bryan; Hecker, Yanina; Moore, Prando Dadin; Zamorano, Patricia Ines (Elsevier, 2021-02)DNA vaccines are capable of inducing humoral and cellular immunity, and are important to control bovine herpesvirus 1 (BoHV-1), an agent of the bovine respiratory disease complex. In previous work, a DNA plasmid that encodes ... -
An improved DNA vaccine against bovine herpesvirus-1 using CD40L and a chemical adjuvant induces specific cytotoxicity in mici
Langellotti, Cecilia Ana; Gammella, Mariela; Soria, Ivana; Bellusci, Carolina; Quattrocchi, Valeria; Vermeulen, Elba Monica; Mongini, Claudia; Zamorano, Patricia Ines (Mary Ann Liebert, 2021-03)Bovine herpesvirus-1 (BoHV-1) uses many mechanisms to elude the immune system; one of them is spreading intracellularly, even in the presence of specific antiviral antibodies. Cytotoxic T lymphocytes (CTLs) are necessary ... -
Bovine interferon lambda Is a potent antiviral against SARS-CoV-2 infection in vitro
Cardoso, Nancy; Mansilla, Florencia Celeste; Benedetti, Estefanía; Turco, Cecilia Soledad; Barone, Lucas Jose; Iserte, Javier Alonso; Soria, Ivana; Baumeister, Elsa; Capozzo, Alejandra (Frontiers Media, 2020-11)Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces. This localized activity results in reduced ... -
Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma
Cocozza, Federico; Menay, Florencia; Tsacalian, Rodrigo Farid; Elisei, Analia; Sampedro, Pura; Soria, Ivana; Waldner, Claudia Inés; Gravisaco, María José; Mongini, Claudia (Elsevier, 2019-03)Exosomes are 60–150 nm small extracellular vesicles (EVs) released by most cells. Tumor-cell-derived exosomes, used as a vaccine, elicit a specific cytotoxic response against tumor cells, usually with a greater immunogenicity ... -
Dendrimeric peptides can confer protection against foot-and-mouth disease virus in cattle
Soria, Ivana; Quattrocchi, Valeria; Langellotti, Cecilia Ana; Gammella, Mariela; Di Giacomo, Sebastián; Garcia de la Torre, Beatriz; Andreu, David; Montoya, Maria; Sobrino, Francisco; Blanco, Esther; Zamorano, Patricia Ines (2017-09)Foot-and-mouth disease virus (FMDV) causes a highly contagious disease in cloven-hoofed animals. A synthetic vaccine candidate consisting of dendrimeric peptides harbouring two copies of a B-epitope [VP1(136–154)] linked ... -
FMD empty capsids combined with the immunostant particle adjuvant -ISPA or ISA206 induce protective immunity against foot and mouth disease virus
Bidart, Juan Esteban; Mignaqui, Ana Clara; Kornuta, Claudia Alejandra; Lupi, Giuliana; Gammella, Mariela; Soria, Ivana; Galarza, Roxana Ivon; Ferella, Alejandra; Cardillo, Sabrina Beatriz; Langellotti, Cecilia Ana; Quattrocchi, Valeria; Durocher, Yves; Wigdorovitz, Andres; Marcipar, Ivan; Zamorano, Patricia Ines (Elsevier, 2021-05)Foot and Mouth Disease Virus (FMDV) causes economy losses and is controlled by vaccination in many countries. Vaccine formulations based on empty capsids or Virus-Like Particles (VLPs) have the advantage of avoiding the ... -
Foot-and-mouth disease virus infection of dendritic cells triggers phosphorylation of ERK1/2 inducing class I presentation and apoptosis
Langellotti, Cecilia Ana; Cesar, Gonzalo; Soria, Ivana; Quattrocchi, Valeria; Jancic, Carolina Cristina; Zamorano, Patricia Ines; Vermeulen, Elba Monica (Elsevier, 2015-09)Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. This pathology is caused by foot-and-mouth disease virus (FMDV). Over time, the development of vaccines to prevent the spread of ... -
Immune Response and Partial Protection against Heterologous Foot-and-Mouth Disease Virus Induced by Dendrimer Peptides in Cattle
Soria, Ivana; Quattrocchi, Valeria; Langellotti, Cecilia Ana; Perez Filgueira, Daniel Mariano; Pega, Juan Franco; Gnazzo, Victoria; Romera, Sonia Alejandra; Schammas, Juan Manuel; Bucafusco, Danilo; Di Giacomo, Sebastián; García de la Torre, Beatriz; Andreu, David; Sobrino, Francisco; Blanco, Esther; Zamorano, Patricia Ines (2018-04)Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to ... -
MANα1-2MAN decorated liposomes enhance the immunogenicity induced by a DNA vaccine against BoHV-1
Kornuta, Claudia Alejandra; Bidart, , Juan Esteban; Soria, Ivana; Gammella, Mariela; Quattrocchi, Valeria; Pappalardo, Juan Sebastián; Salmaso, Stefano; Torchilin, Vladimir P.; Cheuquepan Valenzuel, Felipe Andres; Hecker, Yanina; Moore, Dadin P.; Zamorano, Patricia Ines; Langellotti, Cecilia Ana (Wiley, 2021-03)New technologies in the field of vaccinology arise as a necessity for the treatment and control of many diseases. Whole virus inactivated vaccines and modified live virus ones used against Bovine Herpesvirus‐1 (BoHV‐1) ... -
Mouse model as an efficacy test for foot‐and‐mouth disease vaccines
Gnazzo, Victoria; Quattrocchi, Valeria; Soria, Ivana; Pereyra, Erica Vanesa; Langellotti, Cecilia Ana; Pedemonte, Andrea; López, Virginia; Marangunich, Laura An; Zamorano, Patricia Ines (Wiley, 2020-04)Protection against foot‐and‐mouth disease virus (FMDV) has been linked to the development of a humoral response. In Argentina, the official control tests for assessing the potency of FMD vaccines are protection against ... -
TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1
Kornuta, Claudia Alejandra; Cheuquepan Valenzuel, Felipe Andres; Bidart, , Juan Esteban; Soria, Ivana; Gammella, Mariela; Quattrocchi, Valeria; Hecker, Yanina; Moore, Prando Dadin; Romera, Sonia Alejandra; Marin, Maia Solange; Zamorano, Patricia Ines; Langellotti, Cecilia Ana (Elsevier, 2022-01)The innate and acquired immune response induced by a commercial inactivated vaccine against Bovine Herpesvirus-1 (BoHV-1) and protection conferred against the virus were analyzed in cattle. Vaccination induced high levels ...