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Actividad del interferón de tipo III contra el virus de la diarrea viral bovina
(Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, 2019)El Virus de la Diarrea Viral Bovina (VDVB) representa un importante desafío a nivel productivo debido a su carácter endémico a nivel mundial. La infección por el VDVB es altamente prevalente en la Argentina y provoca ... -
Antiviral agents against equid alphaherpesviruses : current status and perspectives
(2016)Equid herpesvirus infections cause respiratory, neurological and reproductive syndromes. Despite preventive and control measures and the availability of vaccines and immunostimulants, herpesvirus infections still constitute ... -
Artificial microRNAs as antiviral strategy to FMDV: structural implications of target selection
(2014-04)RNA interference (RNAi) appears as a promising strategy to control virus replication. While the antiviral power of short-hairpin RNAs or small-interfering RNAs against FMDV has been demonstrated widely, safer RNAi effectors ... -
Baculovirus vectors induce the production of interferons in swine : their potential in the development of antiviral strategies
(MDPI, 2021-11)The huge variety of viruses affecting swine represents a global threat. Since vaccines against highly contagious viruses last several days to induce protective immune responses, antiviral strategies for rapid control of ... -
Bovine interferon lambda Is a potent antiviral against SARS-CoV-2 infection in vitro
(Frontiers Media, 2020-11)Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces. This localized activity results in reduced ... -
In vitro comparison of acyclovir, ganciclovir and cidofovir against equid alphaherpesvirus 3 and evaluation of their efficacy against six field isolates = Comparación in vitro de aciclovir, ganciclovir y cidofovir contra alfa-herpesvirus equino 3 y evaluación de la eficacia de los mismos frente a 6 aislamientos de campo del virus
(Asociación Argentina de Microbiología, 2018)Equid alphaherpesvirus 3 (EHV3) is the etiological agent of equine coital exanthema (ECE), which is a venereal, highly contagious disease, characterized by the formation of papules, vesicles, pustules and ulcers on the ... -
In-vivo activity of IFN-λ and IFN-α against bovine-viral-diarrhea virus in a mouse model
(Frontiers Media, 2020-02)Bovine-viral-diarrhea virus (BVDV) can cause significant economic losses in livestock. The disease is controlled with vaccination and bovines are susceptible until vaccine immunity develops and may remain vulnerable if a ... -
Interferon lambda protects cattle against bovine viral diarrhea virus infection
(Elsevier, 2020-12)Interferon lambda (IFN-λ) plays an important role in inducing an antiviral state in mucosal surfaces and has been used as an effective biotherapeutic against several viral diseases. Here we performed a proof of concept ... -
P26 enhances baculovirus gene delivery by modulating the mammalian antiviral response
(Springer, 2023-08)Poxins are poxviral proteins that act by degrading 2´3´-cGAMP, a key molecule of cGAS-STING axis that drives and amplifies the antiviral response. Previous works have described some poxin homologous among lepidopteran and ... -
Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
(Elsevier, 2021-08)Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases ... -
Structure-based drug design for envelope protein E2 uncovers a new class of bovine viral diarrhea inhibitors that block virus entry
(Elsevier, 2018-01)Antiviral targeting of virus envelope proteins is an effective strategy for therapeutic intervention of viral infections. Here, we took a computer-guided approach with the aim of identifying new antivirals against the ... -
Ursolic acid : a novel antiviral compound inhibiting rotavirus infection in vitro
(Elsevier, 2019-11)Rotavirus is one of the leading causes of severe acute gastroenteritis in children under 5 years of age, mainly affecting developing countries. Once the disease is acquired, no specific treatment is available; as such, the ...