• Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles 

      Bigi, María Mercedes; Vazquez, Cristina Lourdes; Castelão, Ana Beatriz C.; Garcia, Elizabeth Andrea; Cataldi, Angel Adrian; Jackson, Mary; McNeil, Michael; Soria, Marcelo Abel; Zumarraga, Martin Jose; Cabruja, Matias; Gago, Gabriela; Blanco, Federico Carlos; Nishibe, Christiane; Almeida Junior, Nalvo Franco de; Araujo, Flabio Ribeiro de; Bigi, Fabiana (Elsevier, 2019-12)
      Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic ...
    • Asociación entre la densidad óptica y hallazgos post mortem compatibles con tuberculosis en bovinos positivos al test de ELISA 

      Sammarruco, Romina Ayelén; Delgado, Fernando Oscar; Garro, Carlos Javier; Bermejo Laudecina, Virginia Soledad; De La Fuente, Damian Ignacio; Ruiz Menna, Victoria Aymara; Garbaccio, Sergio Gabriel (Asosiación Argentina de Veterinarios de Laboratorios de Díagnóstico, 2021-11)
      Introducción. La tuberculosis bovina (TB) es una enfermedad infecto-contagiosa causada principalmente por Mycobacterium bovis. Genera un impacto económico negativo en la producción pecuaria y también en la salud pública, ...
    • Bayesian assessment of the accuracy of a PCR-based rapid diagnostic test for bovine tuberculosis in swine 

      Barandiaran, Soledad; Perez Aguirreburualde, María Sol; Marfil, María Jimena; Martinez Vivot, Marcela; Aznar, Maria Natalia; Zumarraga, Martin Jose; Pérez, Andrés M. (Frontiers Media, 2019-06)
      Infection with the Mycobacterium bovis (M. bovis) causes a disease referred to as bovine tuberculosis (bTB), which affects a wide range of mammal hosts. Many countries have implemented control and eradication plans that ...
    • BoLA-DRB3 exon2 polymorphisms among tuberculous cattle: Nucleotide and functional variability and their association with bovine tuberculosis pathology 

      Eirin, Maria Emilia; Carignano, Hugo Adrian; Shimizu, Ernesto; Pando, Maria de los Angeles; Zumarraga, Martin Jose; Magnano, Gabriel; Macías, Analía; Garbaccio, Sergio Gabriel; Huertas, Pablo Sebastian; Morsella, Claudia Graciela; Ferrara Muñiz, Ximena; Cataldi, Angel Adrian; Paolicchi, Fernando; Poli, Mario Andres (Elsevier, 2020-06)
      Bovine tuberculosis (bTB) is caused by Mycobacterium bovis and disseminated worldwide. In Argentina, the highest prevalence occurs in dairy areas. BoLA DRB3.2 is related to the adaptive immunity in mycobacterial infections. ...
    • Comparación de la respuesta a la prueba de la tuberculina en dos sitios de aplicación en bovinos con tuberculosis 

      Garro, Carlos Javier; Cobos Roldán, Miguel; Delgado, Fernando Oscar; Garbaccio, Sergio Gabriel (INTA Ediciones, 2022-05)
      El diagnóstico de tuberculosis bovina (TB) se realiza a través de la prueba de la tuberculina (PT). En Argentina, el diagnóstico operativo de rutina se aplica en el pliegue ano caudal (PAC) interno utilizando PPD bovina ...
    • Desarrollo de alternativas diagnósticas de tuberculosis bovina 

      Leiva, Carlos (Universidad Nacional de Quilmes, 2015-02)
      En el siguiente trabajo se llevó cabo la puesta a punto y optimización de la técnica LAMP (del inglés loop-mediated isothermal amplification) para la detección de Mycobacterium bovis, agente etiológico de la tuberculosis ...
    • Descripción de la evolución de tuberculosis en rodeos lecheros combinando el uso de IDR y ELISA 

      Sammarruco, Romina Ayelén; Garro, Carlos Javier; Delgado, Fernando Oscar; Bermejo Laudecina, Virginia Soledad; De La Fuente, Damian Ignacio; Ruiz Menna, Victoria Aymara; Garbaccio, Sergio Gabriel (Asosiación Argentina de Veterinarios de Laboratorios de Díagnóstico, 2021-11)
      La tuberculosis bovina (TB) produce un impacto negativo en la producción pecuaria y la salud pública. La respuesta inmune a la infección es predominantemente mediada por células. En ello se fundamenta el diagnóstico a ...
    • Detection of Mycobacterium bovis in Bovine and Bubaline tissues using Nested-PCR for TbD1 

      Araújo, Cristina Pires de; Osório, Ana Luiza Alves Rosa; Jorge, Klaudia dos Santos Goncalves; Ramos, Carlos Alberto N.; Filho, Antonio Francisco S.; Vidal, Carlos Eugênio Soto; Roxo, Eliana; Nishibe, Christiane; Almeida Junior, Nalvo Franco de; Júnior, Antônio A. F.; Silva, Marcio Roberto; Neto, Jose Diomedes Barbosa; Cerqueira, Valíria Duarte; Zumarraga, Martin Jose; Araujo, Flabio Ribeiro de (PLOS, 2014-03)
      In the present study, a nested-PCR system, targeting the TbD1 region, involving the performance of conventional PCR followed by real-time PCR, was developed to detect Mycobacterium bovis in bovine/bubaline tissue homogenates. ...
    • Detection of Mycobacterium bovis–infected dairy herds using PCR in bulk tank milk samples 

      Zumarraga, Martin Jose; Soutullo, Adriana; Garcia, Maria Ines; Marini, M. Rocío; Abdala, Alejandro Ariel; Tarabla, Hector Dante; Echaide, Susana T. de; Lopez, Marcela; Zervini, Elsa; Canal, Ana María; Cataldi, Angel Adrian (Mary Ann Liebert Inc., 2012-02)
      Bovine tuberculosis (bTB) is a chronic and zoonotic disease due to Mycobacterium bovis. The tuberculosis eradication campaign carried out in Argentina has considerably improved the health situation of the herds. Here we ...
    • Development and diagnostic validation of an ELISA based on an antigenic mixture for the detection of bovine tuberculosis 

      Griffa, Natanael; Moyano, Roberto Damián; Canal, Ana María; Traveria, Gabriel Eduardo; Santangelo, María De La Paz; Alonso, Maria Natalia; Romano, Maria Isabel (Elsevier, 2020-02)
      Programs for the eradication of bovine tuberculosis (bTB) focus on the tuberculin skin test (TST) and slaughter of reactor cattle. However, the disease remains an animal health concern in several countries and improving ...
    • Development of a lateral flow immunochromatography test for the rapid detection of bovine tuberculosis 

      Alonso, Maria Natalia; Griffa, Natanael; Moyano, Roberto Damián; Mon, Maria Laura; Colombatti Olivieri, Maria Alejandra; Barandiaran, Soledad; Martinez Vivot, Marcela; Fiorini, Gonzalo; Canal, Ana María; Santangelo, María De La Paz; Singh, Mahavir G.; Romano, Maria Isabel (Elsevier, 2021-04)
      Detection of specific antibodies would be a useful test strategy for bovine tuberculosis (bTB) as a complement to the single skin test. We developed a lateral flow immunochromatography (LFIC) test for rapid bTB detection ...
    • Diagnóstico bacteriológico de tuberculosis bovina en bovinos reactores positivos a la prueba tuberculínica 

      Garbaccio, Sergio Gabriel; Delgado, Fernando Oscar; Zumarraga, Martin Jose; Rodriguez, Liliana Rita; Huertas, Pablo Sebastian; Garro, Carlos Javier (2018-04)
      Mycobacterium bovis es el agente causal de la tuberculosis bovina (TBB), enfermedad zoonótica que afecta la producción láctea y cárnica. En nuestro país, el diagnóstico se realiza a través de la prueba tuberculínica o ...
    • Enzyme-linked immunosorbent assay as complement of intradermal skin test for the detection of mycobacterium bovis infection in cattle 

      Garbaccio, Sergio Gabriel; Garro, Carlos Javier; Delgado, Fernando Oscar; Tejada, G. A.; Eirin, Maria Emilia; Huertas, Pablo Sebastian; Leon, Emilio Arnaldo; Zumarraga, Martin Jose (Elsevier, 2019-07)
      Diagnostic tests based on cell-mediated immunity are used in programs for the control and eradication of bovine tuberculosis (bTB), which is mainly caused by Mycobacterium bovis. Additional serological assays could be ...
    • Epidemiology of Pig Tuberculosis in Argentina 

      Barandiaran, Soledad; Marfil, Maria Jimena; Capobianco, Guillermo; Perez Aguirreburualde, María Sol; Zumarraga, Martin Jose; Eirin, Maria Emilia; Cuerda, Maria Ximena; Winter, Marina; Martinez Vivot, Marcela; Pérez, Andrés Maximiliano; La Sala, Luciano Francisco (Frontiers Editorial, 2021-07)
      Bovine tuberculosis (bTB) is a disease caused mainly by the Mycobacterium bovis and that is endemic to livestock populations in most Latin American countries. Traditionally, bTB control programs are costly and targeted to ...
    • ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis 

      Blanco, Federico Carlos; Soria, Marcelo Abel; Klepp, Laura Ines; Bigi, Fabiana (Karger, 2017-12)
      Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses ...
    • Evaluación de antígenos recombinantes en la prueba de interferón gamma en bovinos tuberculosos no reactores a la prueba tuberculínica 

      Ferrara Muñiz, Ximena; Garbaccio, Sergio Gabriel; Delgado, Fernando Oscar; Garro, Carlos Javier; Huertas, Pablo Sebastian; Marfil, Maria Jimena; Zumarraga, Martin Jose; Eirin, Maria Emilia (Asosiación Argentina de Veterinarios de Laboratorios de Díagnóstico, 2018-11)
      La tuberculosis se encuentra presente en rodeos bovinos de nuestro país, impactando a nivel de los sistemas de producción de cría y lecheros por disminuir la eficiencia productiva de los animales infectados e imponer ...
    • Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle 

      Hasenauer, Flavia Carolina; Garbaccio, Sergio Gabriel; Caffaro, María Eugenia; Garro, Carlos Javier; Huertas, Pablo Sebastian; Poli, Mario Andres; Rossetti, Carlos Alberto (2018-04)
      Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. ...
    • FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis 

      Mondino, Sonia; Vazquez, Cristina Lourdes; Cabruja, Matias; Sala, Claudia; Cazenave-Gassiot, Amaury; Blanco, Federico Carlos; Wenk, Markus R.; Bigi, Fabiana; Cole, Stewart T.; Gramajo, Hugo; Gago, Gabriela (Frontiers Media, 2020-10)
      Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is the world’s leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition ...
    • First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn 

      Echeverria, Gustavo; Rueda, Veronica; Espinoza, Wilson; Rosero, Carlos; Zumarraga, Martin Jose; Waard, Jacobus H. de (MDPI, 2023-04)
      Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that ...
    • Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts 

      Morcillo, Nora; Imperiale, Belen Rocio; Di Giulio, Angela Beatríz; Zumarraga, Martin Jose; Takif, Howard; Cataldi, Angel Adrian (Elsevier, 2014-12)
      There has been an on-going debate on whether the development of drug resistance in Mycobacterium tuberculosis reduces its relative fitness and its ability to cause disease. The aim of this study was to explore this ...