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Baculovirus capsid display in vaccination schemes: effect of a previous immunity against the vector on the cytotoxic response to delivered antigens
Molinari, Maria Paula; Molina, Guido Nicolás; Tavarone, Maria Eugenia; Del Medico Zajac, Maria Paula; Moron, Victor Gabriel; Taboga, Oscar Alberto (Springer, 2018-12)The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, although it also has been used as display vector for vaccine development. In this ... -
Double-layered rotavirus-like particles are efficient carriers to elicit strong CTL responses to delivered heterologous antigens
Molinari, Maria Paula; Peralta, Andrea Veronica; Maletto, Belkys Angélica; Pistoresi Palencia, Maria Cristina; Crespo, Maria Ines; Moron, Victor Gabriel; Taboga, Oscar Alberto (Elsevier, 2014-11)The first 92 amino acids of VP2 of rotavirus are dispensable for VLP assembly and can be replaced by heterologous reporter proteins without affecting either self-assembly of chimeric VP2 or the interaction with VP6 to ... -
MVAΔ008 viral vector encoding the model protein OVA induces improved immune response against the heterologous antigen and equal levels of protection in a mice tumor model than the conventional MVA
Del Medico Zajac, Maria Paula; Molinari, Maria Paula; Gravisaco, María José; Maizon, Daniel Omar; Moron, Victor Gabriel; Gherardi, Maria Magdalena; Calamante, Gabriela (Elsevier, 2021-11)Modified vaccinia Ankara virus (MVA) is extensively used as a vaccine vector. We have previously observed that MVAΔ008, an MVA lacking the gene that codes for interleukin-18 binding protein, significantly increases CD8+ ... -
TLR9 activation is required for cytotoxic response elicited by baculovirus capsid display
Molinari, Maria Paula; Crespo, Maria Ines; Molina, Guido Nicolas; Dho, Nicolás D.; Marinho, Fábio V.; Maletto, Belkys Angélica; Leclerc, Claude; Oliveira, Sergio C.; Taboga, Oscar Alberto; Cebrian, Ignacio; Moron, Victor Gabriel (Wiley, 2023-05)Although the baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, represents an efficient vector for vaccine development. Baculovirus surface ...