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Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
(Elsevier, 2013-05-31)Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were ... -
Combined live oral priming and intramuscular boosting regimen with Rotarix® and a nanoparticle-based trivalent rotavirus vaccine evaluated in gnotobiotic pig models of G4P[6] and G1P[8] human rotavirus infection
(MDPI, 2023-05)Human rotavirus (HRV) is the causative agent of severe dehydrating diarrhea in children under the age of five, resulting in up to 215,000 deaths each year. These deaths almost exclusively occur in low- and middle-income ... -
Comparación de la respuesta inmune humoral y celular de las vacunas Brucella abortus cepa RB51 y cepa 19 en vaquillonas Hereford de Patagonia y su interferencia con el diagnóstico serológico de la enfermedad
(Sociedad de Medicina Veterinaria, 2007)Se llevó a cabo un estudio de campo controlado donde se usaron 2 grupos homogéneos de 25 vaquillonas Hereford cada uno, de 10 meses de edad, provenientes de un establecimiento libre de brucelosis y donde nunca se había ... -
Complete Genome Sequence of Chlamydia abortus MRI-10/19, Isolated from a Sheep Vaccinated with the Commercial Live C. abortus 1B Vaccine Strain
(American Society for Microbiology, 2021-05)We report the complete genome sequence of Chlamydia abortus MRI-10/19, recovered from the infected placenta of a sheep that had been vaccinated with the commercial live attenuated C. abortus 1B vaccine strain. Comparative ... -
Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma
(Elsevier, 2019-03)Exosomes are 60–150 nm small extracellular vesicles (EVs) released by most cells. Tumor-cell-derived exosomes, used as a vaccine, elicit a specific cytotoxic response against tumor cells, usually with a greater immunogenicity ... -
Degrade to survive : the intricate world of piroplasmid proteases
(Elsevier, 2023-07)Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate ... -
Deletion of A44L, A46R and C12L vaccinia virus genes from the MVA genome improved the vector immunogenicity by modifying the innate immune response generating enhanced and optimized specific T-Cell responses
(2016-05)MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity ... -
Dendritic cell targeting in cultured fish in Argentina for vaccine development
(Edición del Autor, 2019)In Argentina two main species present an important economic value, these are Pacú (Piaractus mesopotamicus, Pm) and Rainbow Trout (Oncorhynchus mykiss, Om). Due to stress and changing environmental conditions cultured fish ... -
Desarrollo de candidatos vacunales contra Babesia bovis basados en vectores virales y proteínas recombinantes
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2016-09)La babesiosis bovina es una enfermedad parasitaria trasmitida por garrapatas y causada por los protozooarios intraeritrocíticos Babesia bovis y B. bigemina. Esta infección provoca importantes pérdidas económicas en varias ... -
Desarrollo de un inmunógeno prototípico para el control de mastitis bovinas causadas por Staphylococcus aureus
(Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 2012)Staphylococcus aureus es el patógeno más frecuentemente aislado de casos de mastitis bovina en Argentina y el mundo. Las particulares características de las infecciones intramamarias por S. aureus, han llevado a la búsqueda ... -
Desarrollo y evaluación de tecnología para la detección de proteínas no estructurales del Virus de la Fiebre Aftosa en formulaciones vacunales
(Universidad Nacional de San Martín, 2009)La fiebre aftosa (FA) es una enfermedad viral altamente contagiosa que afecta a todas las especies de pezuña hendida, salvajes y domésticas. Las especies domésticas principalmente afectadas son los bovinos, porcinos, ovinos ... -
Desarrollo y evaluación de un candidato vacunal para IBD producido en plantas: una alternativa a las vacunas tradicionales
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2018)El Virus de la enfermedad infecciosa de la bursa (IBDV) es el agente etiológico responsable de una enfermedad aguda contagiosa e inmunosupresora que afecta pollos jóvenes y causa importantes pérdidas económicas. La vacunación ... -
Development and biological evaluation of pNIPAM-based nanogels as vaccine carriers
(Elsevier, 2023-01)“Smart” nanogels are an attractive tool for the development of new strategies of immunization in veterinary medicine. Here, we reported the synthesis and physicochemical characterization of thermoresponsive nanogels based ... -
Development of an APC-targeted multivalent E2-based vaccine against Bovine Viral Diarrhea Virus types 1 and 2
(Elsevier, 2015-09)The aim of this study was to develop and test a multivalent subunit vaccine against Bovine Viral Diarrhea Virus (BVDV) based on the E2 virus glycoprotein belonging to genotypes 1a, 1b and 2a, immunopotentiated by targeting ... -
Developments in plant-based vaccines against diseases of concern in developing countries
(BENTHAM Open, 2010)Vaccination has been extensively used to prevent, eradicate and control infectious diseases. However, the development and implementation of new vaccines remains prohibitively expensive for middle and low income countries where ... -
Diagnóstico y prevención de la neosporosis bovina. Desarrollo de técnicas serológicas y evaluación de inmunógenos basados en proteínas recombinantes
(Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, 2019)La neosporosis es una enfermedad abortígena, causada por el parásito protozoario Neospora caninum. No hay tratamientos o vacunas disponibles, el control se basa en el diagnóstico y las estrategias de manejo. Se desarrollaron ... -
Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
(MDPI, 2021-05)Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the ... -
Double-layered rotavirus-like particles are efficient carriers to elicit strong CTL responses to delivered heterologous antigens
(Elsevier, 2014-11)The first 92 amino acids of VP2 of rotavirus are dispensable for VLP assembly and can be replaced by heterologous reporter proteins without affecting either self-assembly of chimeric VP2 or the interaction with VP6 to ... -
Duplex PCR for the diagnosis of Brucella melitensis and its differentiation from the REV-1 vaccine strain
(2016)La brucelosis caprina es una enfermedad infecciosa crónica causada por Brucella melitensis, cuyos principales síntomas son el aborto en mujeres y orquitis en varones. La vacunación por error de cabras embarazadas con la ... -
Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant
(Elsevier, 2014-04-17)Foot and mouth disease is an acute disease of cattle with a broad distribution around the world. Due to the fast spread of FMDV infections, control measures must be applied immediately after an outbreak, such as the use ...