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Mostrando ítems 21-34 de 34
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Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice
Mansilla, Florencia Celeste; Quintana, Maria Eugenia; Langellotti, Cecilia Ana; Wilda, Maximiliano; Martinez, Andrea; Fonzo, Adriana; Moore, Prando Dadin; Cardoso, Nancy; Capozzo, Alejandra (2016)Profilins are actin-binding proteins that regulate the polymerization of actin filaments. In apicomplexan parasites, they are essential for invasion. Profilins also trigger the immune response of the host by activating ... -
Impact of genetic ancestry on the distribution of interferon-λ4 RS12979860 polymorphism in a global population of Buenos Aires, Argentina = Impacto de la ancestría genética en la distribución del polimorfismo de interferón-λ4 RS12979860 en una población global de Buenos Aires, Argentina
Mansilla, Florencia Celeste; Avena, Sergio; Dejean, Cristina; Turco, Cecilia Soledad; Capozzo, Alejandra (Sociedad Argentina de Genética, 2022-12)Human interferon-λ4 is a cytokine involved in early stages of antiviral responses. Strikingly, some allelic variants with diminished antiviral activity reduce the susceptibility to viral infections, thus they would have ... -
In vitro and in vivo characterization of a typical and a high pathogenic bovine viral diarrhea virus type ii strains
Malacari, Darío Amilcar; Pecora, Andrea; Perez Aguirreburialde, Maria Sol; Cardoso, Nancy Patricia; Odeon, Anselmo Carlos; Capozzo, Alejandra Victoria (Frontiers Media, 2018-04)Non-cytopathic (ncp) type 2 bovine viral diarrhea virus (BVDV-2) is widely prevalent in Argentina causing high mortality rates in cattle herds. In this study, we characterized an Argentinean ncp BVDV-2 field isolate (98-124) ... -
In-vivo activity of IFN-λ and IFN-α against bovine-viral-diarrhea virus in a mouse model
Quintana, Maria Eugenia; Barone, Lucas Jose; Trotta, Myrian Vanesa; Turco, Cecilia Soledad; Mansilla, Florencia Celeste; Capozzo, Alejandra; Cardoso, Nancy (Frontiers Media, 2020-02)Bovine-viral-diarrhea virus (BVDV) can cause significant economic losses in livestock. The disease is controlled with vaccination and bovines are susceptible until vaccine immunity develops and may remain vulnerable if a ... -
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines
Bucafusco, Danilo; Di Giacomo, Sebastián; Pega, Juan Franco; Juncos, María Sol; Schammas, Juan Manuel; Perez Filgueira, Daniel Mariano; Capozzo, Alejandra Victoria (2014-11-12)Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred ... -
Interferon lambda protects cattle against bovine viral diarrhea virus infection
Quintana, Maria Eugenia; Cardoso, Nancy; Pereyra, Walter Rodrigo; Barone, Lucas Jose; Barrionuevo, Florencia Mariel; Mansilla, Florencia Celeste; Turco, Cecilia Soledad; Capozzo, Alejandra (Elsevier, 2020-12)Interferon lambda (IFN-λ) plays an important role in inducing an antiviral state in mucosal surfaces and has been used as an effective biotherapeutic against several viral diseases. Here we performed a proof of concept ... -
Kinetics of foot-and-mouth disease vaccine-induced antibody responses in buffaloes (Bubalus bubalis): avidity ELISA as an alternative to the virus neutralization test
Sala, Juan Manuel; Mansilla, Florencia Celeste; Miraglia, Maria Cruz; Caspe, Sergio Gaston; Perez Filgueira, Daniel Mariano; Capozzo, Alejandra (Frontiers Media, 2023-11)The role of water buffaloes in foot-and-mouth disease (FMD) epidemiology as one of the major hosts of the virus that can develop persistent asymptomatic infection highlights the importance of sustaining surveillance on the ... -
Morir en soledad: la terrible situación de las personas que fallecen por COVID-19 y el dolor de sus familiares en un contexto de desborde del sistema de salud
Capozzo, Alejandra (Sociedad Argentina de Medicina, 2020-09)La Organización Mundial de la Salud declaró la pandemia de covid-19 el 11 de marzo de 2020. El coronavirus pandémico afecta a todo el mundo desde que se identificó en diciembre de 2019 en Wuhan, China. La pandemia causó ... -
Prevalencia sérica de Neospora caninum y factores de riesgo asociados a su transmisión en tambos de la provincia de Salta, Argentina
Pereyra, Walter Rodrigo; Suarez, Victor Humberto; Cardoso, Nancy; Gual, Ignacio; Martinez, Gabriela Marcela; Capozzo, Alejandra; Mansilla, Florencia Celeste (Elsevier, 2020-09-11)El objetivo de este trabajo fue conocer la seroprevalencia de Neospora caninum en los bovinos de los tambos del Valle del Lerma (Salta, Argentina) y los factores de riesgo asociados a la transmisión de este parásito en ... -
Serological screening of SARS-CoV-2 infection in companion animals of Buenos Aires suburbs
Cardoso, Nancy; Rivero, Carla; Castillo, Mariangeles; Mansilla, Florencia Celeste; Pastorino, Florencia; Piccirilli, Guadalupe; Alonso, Laura; Martinez, Gustavo; Di Lullo, David; Bentancor, Leticia Veronica; Capozzo, Alejandra (Frontiers Media, 2023-05)The Coronavirus Disease 2019 (COVID-19) is a zoonotic disease caused by the pandemic virus SARS-CoV-2. Domestic and wild animals are susceptible to infection and are potential reservoirs for virus variants. To date, there ... -
Structure-based drug design for envelope protein E2 uncovers a new class of bovine viral diarrhea inhibitors that block virus entry
Pascual, María José; Merwaiss, Fernando; Leal, Emilse Soledad; Quintana, Maria Eugenia; Capozzo, Alejandra Victoria; Cavasotto, Claudio Norberto; Bollini, Mariela; Alvarez, Diego Ezequiel (Elsevier, 2018-01)Antiviral targeting of virus envelope proteins is an effective strategy for therapeutic intervention of viral infections. Here, we took a computer-guided approach with the aim of identifying new antivirals against the ... -
Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge
Barrionuevo, Florencia Mariel; Di Giacomo, Sebastián; Bucafusco, Danilo; Ayude, Andrea Fabiana; Schammas, Juan Manuel; Miraglia, María Cruz; Capozzo, Alejandra Victoria; Borca, Manuel Victor; Perez Filgueira, Daniel Mariano (2018-05)The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days ... -
Systemic Foot-and-Mouth Disease Vaccination in Cattle Promotes Specific Antibody-Secreting Cells at the Respiratory Tract and Triggers Local Anamnestic Responses upon Aerosol Infection
Pega, Juan Franco; Di Giacomo, Sebastián; Bucafusco, Danilo; Schammas, Juan Manuel; Malacari, Darío Amilcar; Barrionuevo, Florencia Mariel; Capozzo, Alejandra Victoria; Rodríguez, L.L.; Borca, Manuel Victor; Perez Filgueira, Daniel Mariano (2015-09)Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting biungulate species. Commercial vaccines, formulated with inactivated FMD virus (FMDV), are regularly used worldwide to control the disease. Here, ... -
The role of viral particle integrity in the serological assessment of foot-and-mouth disease virus vaccine-induced immunity in swine
Mansilla, Florencia Celeste; Turco, Cecilia Soledad; Miraglia, Maria Cruz; Bessone, Fernando Aníbal; Franco, Raul Enrique; Perez Filgueira, Daniel Mariano; Sala, Juan Manuel; Capozzo, Alejandra (Plos One, 2020-05)The efficacy of foot-and-mouth disease virus (FMDV) inactivated vaccines is mainly dependent on the integrity of the whole (146S) viral particles. If the intact capsids disassemble to 12S subunits, antibodies against ...