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A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice
Montenegro, Valeria Noely; Jaramillo Ortiz, Jose; Paoletta, Martina; Gravisaco, María José; Del Medico Zajac, Maria Paula; Garanzini, Debora Patricia; Valenzano, Magali Nicole; Calamante, Gabriela; Wilkowsky, Silvina Elizabeth (Elsevier, 2022-09)In the intraerythrocytic protozoan parasites of the genus Babesia both innate and adaptive immune responses are necessary to confer protection against clinical disease. In particular, the adaptive immune response involves ... -
Baculovirus capsid display in vaccination schemes: effect of a previous immunity against the vector on the cytotoxic response to delivered antigens
Molinari, Maria Paula; Molina, Guido Nicolás; Tavarone, Maria Eugenia; Del Medico Zajac, Maria Paula; Moron, Victor Gabriel; Taboga, Oscar Alberto (Springer, 2018-12)The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, although it also has been used as display vector for vaccine development. In this ... -
Deletion of A44L, A46R and C12L vaccinia virus genes from the MVA genome improved the vector immunogenicity by modifying the innate immune response generating enhanced and optimized specific T-Cell responses
Holgado, María Pía; Falivene, Juliana; Maeto, Cynthia; Amigo, Micaela; Pascutti, María Fernanda; Vecchione, María Belén; Bruttomesso, Andrea; Calamante, Gabriela; Del Medico Zajac, Maria Paula; Gherardi, Maria Magdalena (2016-05)MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity ... -
Estimación de efectos ambientales sobre el fenotipo de clones de banana mediante Análisis Factorial Múltiple Jerárquico
Del Medico Zajac, Maria Paula; Ermini, José Luis; Tenaglia, Gerardo Carlos; Vitelleschi, María Susana; Lavalle, Andrea; Pratta, Guillermo (2018-10)La banana comestible (Musa spp.) es un híbrido de reproducción asexual. Por tal motivo, se espera que de una generación a la siguiente la combinación de múltiples caracteres fenotípicos se conserve. Sin embargo, las ... -
Estrategia de inmunoprofilaxis para la prevención de la rabia paresiante utilizando un virus canarypox recombinante = Immunoprophylaxis strategy for the prevention of paralytic rabies using a recombinant canarypox virus
Garanzini, Debora Patricia; Rossner, Maria Victoria; Stahringer, Rodolfo Carlos; Micucci, Matías; Perez, Oscar; Del Medico Zajac, Maria Paula; Russo, Susana; Calamante, Gabriela (Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA), 2015-03)La rabia paresiante es una enfermedad causada por el virus rábico transmitido por el vampiro común. En el norte de nuestro país, se registran anualmente un número limitado de casos por lo que es necesaria la implementación ... -
IL-12 DNA Displays efficient adjuvant effects improving immunogenicity of Ag85A in DNA prime/MVA boost immunizations
Morelli, María Paula; Del Medico Zajac, Maria Paula; Pellegrini, Joaquín Miguel; Amiano, Nicolás Oscar; Tateosian, Nancy Liliana; Calamante, Gabriela; Gherardi, Maria Magdalena; García, Verónica Edith (Frontiers Media, 2020-09)Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, ... -
Induction of both local immune response in mice and protection in a rabbit model by intranasal immunization with modified vaccinia ankara virus expressing a secreted form of bovine herpesvirus 1 glycoprotein D
Del Medico Zajac, Maria Paula; Zanetti, Flavia Adriana; Esusy, María Soledad; Federico, Carlos Rodolfo; Zabal, Osvaldo Alfredo; Valera, Alejandro Rafael; Calamante, Gabriela (2017)In this study, we evaluated the immunogenicity and efficacy of mucosal delivery of a recombinant modified vaccinia Ankara virus (MVA) expressing the secreted version of bovine herpesvirus type 1 (BoHV-1) glycoprotein D ... -
Índice de selección para múltiples caracteres en una población de banana (Musa spp.)
Del Medico Zajac, Maria Paula; Ermini, Pablo; Tenaglia, Gerardo Carlos; Vitelleschi, María Susana; Lavalle, Andrea; Pratta, Guillermo (2018-10)La selección de los mejores fenotipos para incrementar la producción agronómica, es una estrategia comúnmente empleada en el Mejoramiento Genético Vegetal. En una especie de reproducción asexual como banana (Musa spp.), ... -
MVAΔ008 viral vector encoding the model protein OVA induces improved immune response against the heterologous antigen and equal levels of protection in a mice tumor model than the conventional MVA
Del Medico Zajac, Maria Paula; Molinari, Maria Paula; Gravisaco, María José; Maizon, Daniel Omar; Moron, Victor Gabriel; Gherardi, Maria Magdalena; Calamante, Gabriela (Elsevier, 2021-11)Modified vaccinia Ankara virus (MVA) is extensively used as a vaccine vector. We have previously observed that MVAΔ008, an MVA lacking the gene that codes for interleukin-18 binding protein, significantly increases CD8+ ... -
Protection induced by a glycoprotein E-deleted bovine herpesvirus type 1 marker strain used either as an inactivated or live attenuated vaccine in cattle
Romera, Sonia Alejandra; Puntel, Mariana; Quattrocchi, Valeria; Del Medico Zajac, Maria Paula; Zamorano, Patricia Ines; Blanco Viera, Francisco Javier; Carrillo, Consuelo; Chowdhury, Shafiqul; Borca, Manuel Victor; Sadir, Ana Maria (BMC, 2014-01)Background: Bovine herpesvirus type 1 (BoHV-1) is the causative agent of respiratory and genital tract infections; causing a high economic loss in all continents. Use of marker vaccines in IBR eradication programs is widely ...