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Browsing by Author "27144339032"
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A new cage-like particle adjuvant enhances protection of foot-and-mouth disease vaccine
Bidart, Juan Esteban; Kornuta, Claudia Alejandra; Gammella, Mariela; Gnazzo, Victoria; Soria, Ivana; Langellotti, Cecilia Ana; Mongini, Claudia; Galarza, Roxana Ivon; Calvinho, Luis Fernando; Lupi, Giuliana; Quattrocchi, Valeria; Marcipar, Ivan; Zamorano, Patricia Ines (Frontiers Media, 2020-07)Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model ... -
An improved DNA vaccine against bovine herpesvirus-1 using CD40L and a chemical adjuvant induces specific cytotoxicity in mici
Langellotti, Cecilia Ana; Gammella, Mariela; Soria, Ivana; Bellusci, Carolina; Quattrocchi, Valeria; Vermeulen, Elba Monica; Mongini, Claudia; Zamorano, Patricia Ines (Mary Ann Liebert, 2021-03)Bovine herpesvirus-1 (BoHV-1) uses many mechanisms to elude the immune system; one of them is spreading intracellularly, even in the presence of specific antiviral antibodies. Cytotoxic T lymphocytes (CTLs) are necessary ... -
Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma
Cocozza, Federico; Menay, Florencia; Tsacalian, Rodrigo Farid; Elisei, Analia; Sampedro, Pura; Soria, Ivana; Waldner, Claudia Inés; Gravisaco, María José; Mongini, Claudia (Elsevier, 2019-03)Exosomes are 60–150 nm small extracellular vesicles (EVs) released by most cells. Tumor-cell-derived exosomes, used as a vaccine, elicit a specific cytotoxic response against tumor cells, usually with a greater immunogenicity ... -
Systemic administration of imiquimod as an adjuvant improves immunogenicity of a tumor-lysate vaccine inducing the rejection of a highly aggressive T-cell lymphoma
Di Sciullo, Maria Paula; Menay, Florencia; Cocozza, Federico; Gravisaco, María José; Waldner, Claudia Inés; Mongini, Claudia (Elsevier, 2019-06)T-cell lymphomas include diverse malignancies. They are rare, some have low survival rates and they lack curative therapies. The aim of this work was to assess whether employing the TLR7 agonist imiquimod and the T-cell ...