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An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenic Escherichia coli
Larzabal, Mariano; Baldoni, Hector A.; Suvire, Fernando D.; Curto, Lucrecia M.; Gomez, Gabriela E.; Marques Da Silva, Wanderson; Giudicessi, Silvana L.; Camperi, Silvia A.; Delfino, Jose M.; Cataldi, Angel Adrian; Enriz, Daniel (Wiley, 2019-03)Human pathogenic gram‐negative bacteria, such as enteropathogenic Escherichia coli (EPEC), rely on type III secretion systems (T3SS) to translocate virulence factors directly into host cells. The coiled‐coil domains present ... -
Novel Effector Protein EspY3 of Type III Secretion System from Enterohemorrhagic Escherichia coli Is Localized in Actin Pedestals
Larzabal, Mariano; Marques Da Silva, Wanderson; Riviere, Nahuel Agustín; Cataldi, Angel Adrian (MDPI AG, 2018)Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic Escherichia coli (EPEC) are attaching and effacing (A/E) pathogens, which translocate effector proteins to intestinal enterocytes through a type III secretion ... -
Overexpressed proteins in hypervirulent clade 8 and clade 6 strains of Escherichia coli O157:H7 compared to E. coli O157:H7 EDL933 clade 3 strain
Amigo, Natalia; Qi, Zhang; Amadio, Ariel; Qunjie, Zhang; Marques da Silva, Wanderson; Baiyuan, Cui; Zhongjian, Chen; Larzabal, Mariano; Cataldi, Angel Adrian; Jinlong, Bei (2016)Escherichia coli O157:H7 is responsible for severe diarrhea and hemolytic uremic syndrome (HUS), and predominantly affects children under 5 years. The major virulence traits are Shiga toxins, necessary to develop HUS and ...