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Pattern recognition receptors (PRR) and nucleotide‐binding leucine‐rich repeat proteins (NLR) are major components of the plant immune system responsible for pathogen detection. To date, the transcriptional regulation of PRR/NLR genes is poorly understood. Some PRR/NLR genes are affected by epigenetic changes of neighboring transposable elements (TEs) (cis regulation). We analyzed whether these genes can also respond to changes in the epigenetic marks of
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dc.contributor.author | Cambiagno, Damián Alejandro | |
dc.contributor.author | Nota, María Florencia | |
dc.contributor.author | Zavallo, Diego | |
dc.contributor.author | Rius, Sebastián Pablo | |
dc.contributor.author | Casati, Paula | |
dc.contributor.author | Alvarez, Maria Elena | |
dc.contributor.author | Asurmendi, Sebastian | |
dc.date.accessioned | 2019-02-25T17:26:22Z | |
dc.date.available | 2019-02-25T17:26:22Z | |
dc.date.issued | 2018-12 | |
dc.identifier.issn | 1365-313X | |
dc.identifier.other | https://doi.org/10.1111/tpj.14098 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/4488 | |
dc.description.abstract | Pattern recognition receptors (PRR) and nucleotide‐binding leucine‐rich repeat proteins (NLR) are major components of the plant immune system responsible for pathogen detection. To date, the transcriptional regulation of PRR/NLR genes is poorly understood. Some PRR/NLR genes are affected by epigenetic changes of neighboring transposable elements (TEs) (cis regulation). We analyzed whether these genes can also respond to changes in the epigenetic marks of distal pericentromeric TEs (trans regulation). We found that Arabidopsis tissues infected with Pseudomonas syringae pv. tomato (Pst) initially induced the expression of pericentromeric TEs, and then repressed it by RNA‐directed DNA methylation (RdDM). The latter response was accompanied by the accumulation of small RNAs (sRNAs) mapping to the TEs. Curiously these sRNAs also mapped to distal PRR/NLR genes, which were controlled by RdDM but remained induced in the infected tissues. Then, we used non‐infected mom1 (Morpheus’ molecule 1) mutants that expressed pericentromeric TEs to test if they lose repression of PRR/NLR genes. mom1 plants activated several PRR/NLR genes that were unlinked to MOM1‐targeted TEs, and showed enhanced resistance to Pst. Remarkably, the increased defenses of mom1 were abolished when MOM1/RdDM‐mediated pericentromeric TEs silencing was re‐established. Therefore, common sRNAs could control PRR/NLR genes and distal pericentromeric TEs and preferentially silence TEs when they are activated. | eng |
dc.format | application/pdf | eng |
dc.language.iso | eng | |
dc.publisher | Wiley | eng |
dc.rights | info:eu-repo/semantics/restrictedAccess | eng |
dc.source | Plant journal 96 (6) : 1178-1190. (December 2018) | eng |
dc.subject | Arabidopsis Thaliana | es_AR |
dc.subject | Transposones | es_AR |
dc.subject | Transposons | eng |
dc.subject | Epigenético | es_AR |
dc.subject | Epigenetics | eng |
dc.subject | Defense Mechanisms | eng |
dc.subject.other | RdDM | eng |
dc.subject.other | MOM1 | eng |
dc.title | Immune receptor genes and pericentromeric transposons as targets of common epigenetic regulatory elements | eng |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/publishedVersion | eng |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Cambiagno, Damián Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina | es_AR |
dc.description.fil | Fil: Nota, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina | es_AR |
dc.description.fil | Fil: Zavallo, Diego. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina | es_AR |
dc.description.fil | Fil: Rius, Sebastián Pablo. Universidad Nacional de Rosario. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina | es_AR |
dc.description.fil | Fil: Asurmendi, Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina | es_AR |
dc.description.fil | Fil: Casati, Paula. Universidad Nacional de Rosario. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina | es_AR |
dc.description.fil | Fil: Alvarez, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina | es_AR |
dc.subtype | cientifico |
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