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Resumen
Babesia, Cytauxzoon and Theileria are tick-borne apicomplexan parasites of the order Piroplasmida, responsible for diseases in humans and animals. Members of the piroplasmid rhoptry-associated protein-1 (pRAP-1) family have a signature cysteine-rich domain and are important for parasite development. We propose that the closely linked B. microti genes annotated as BMR1_03g00947 and BMR1_03g00960 encode two paralogue pRAP-1-like proteins named BmIPA48 and
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dc.contributor.author | Bastos, Reginaldo | |
dc.contributor.author | Thekkiniath, Jose | |
dc.contributor.author | Ben Mamoun, Choukri | |
dc.contributor.author | Fuller, Lee | |
dc.contributor.author | Molestina, Robert E. | |
dc.contributor.author | Florin-Christensen, Mónica | |
dc.contributor.author | Schnittger, Leonhard | |
dc.contributor.author | Alzan, Heba F. | |
dc.contributor.author | Suarez, Carlos | |
dc.date.accessioned | 2024-02-14T17:07:34Z | |
dc.date.available | 2024-02-14T17:07:34Z | |
dc.date.issued | 2021-11 | |
dc.identifier.issn | 2076-0817 | |
dc.identifier.other | https://doi.org/10.3390/pathogens10111384 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/16604 | |
dc.identifier.uri | https://www.mdpi.com/2076-0817/10/11/1384 | |
dc.description.abstract | Babesia, Cytauxzoon and Theileria are tick-borne apicomplexan parasites of the order Piroplasmida, responsible for diseases in humans and animals. Members of the piroplasmid rhoptry-associated protein-1 (pRAP-1) family have a signature cysteine-rich domain and are important for parasite development. We propose that the closely linked B. microti genes annotated as BMR1_03g00947 and BMR1_03g00960 encode two paralogue pRAP-1-like proteins named BmIPA48 and Bm960. The two genes are tandemly arranged head to tail, highly expressed in blood stage parasites, syntenic to rap-1 genes of other piroplasmids, and share large portions of an almost identical ~225 bp sequence located in their 5′ putative regulatory regions. BmIPA48 and Bm960 proteins contain a N-terminal signal peptide, share very low sequence identity (<13%) with pRAP-1 from other species, and harbor one or more transmembrane domains. Diversification of the piroplasmid-confined prap-1 family is characterized by amplification of genes, protein domains, and a high sequence polymorphism. This suggests a functional involvement of pRAP-1 at the parasite-host interface, possibly in parasite adhesion, attachment, and/or evasion of the host immune defenses. Both BmIPA48 and Bm960 are recognized by antibodies in sera from humans infected with B. microti and might be promising candidates for developing novel serodiagnosis and vaccines. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | MDPI | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/2019-PD-E5-I102-001, Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y la | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | Pathogens 10 (11) : 1384 (Noviembre 2021) | es_AR |
dc.subject | Babesia microti | es_AR |
dc.subject | Piroplasmosis | eng |
dc.subject.other | Human Babesiosis | eng |
dc.subject.other | Babesiosis Humana | es_AR |
dc.title | Babesia microti immunoreactive rhoptry-associated protein-1 paralogs are ancestral members of the piroplasmid-confined RAP-1 family | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | Instituto de Patobiología | es_AR |
dc.description.fil | Fil: Bastos, Reginaldo. Washington State University. College of Veterinary Medicine. Department of Veterinary Microbiology and Pathology; Estados Unidos | es_AR |
dc.description.fil | Fil: Thekkiniath, Jose. Fuller Laboratories; Estados Unidos | es_AR |
dc.description.fil | Fil: Ben Mamoun, Choukri. Yale School of Medicine. Department of Internal Medicine. Section of Infectious Diseases; Estados Unidos | es_AR |
dc.description.fil | Fil: Fuller, Lee. Fuller Laboratories; Estados Unidos | es_AR |
dc.description.fil | Fil: Molestina, Robert E. American Type Culture Collection. Protistology Laboratory; Estados Unidos | es_AR |
dc.description.fil | Fil: Florin-Christensen, Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina | es_AR |
dc.description.fil | Fil: Schnittger, Leonhard. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina | es_AR |
dc.description.fil | Fil: Alzan, Heba F. Washington State University. College of Veterinary Medicine. Department of Veterinary Microbiology and Pathology; Estados Unidos | es_AR |
dc.description.fil | Fil: Alzan, Heba F. National Research Center. Parasitology and Animal Diseases Department; Egipto | es_AR |
dc.description.fil | Fil: Alzan, Heba F. National Research Center. Tick and Tick-Borne Disease Research Unit; Egipto | es_AR |
dc.description.fil | Fil: Suarez, Carlos. Washington State University. College of Veterinary Medicine. Department of Veterinary Microbiology and Pathology; Estados Unidos | es_AR |
dc.description.fil | Fil: Suarez, Carlos. United States Department of Agricultural—Agricultural Research Service. Animal Disease Research Unit; Estados Unidos | es_AR |
dc.subtype | cientifico |
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