resumen
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the ef fect of extracts obtained from endemic Argentinian species of valerians, namely V. carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC from Patagonia and V. ferax
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dc.contributor.author | Marcucci, Carolina | |
dc.contributor.author | Rademacher, Marina | |
dc.contributor.author | Kamecki, Fabiola | |
dc.contributor.author | Pastore, Velentina | |
dc.contributor.author | Bach, Hernán Gerónimo | |
dc.contributor.author | Ricco, Rafael Alejandro | |
dc.contributor.author | Wagner, Marcelo Luis | |
dc.contributor.author | Knez, Damijan | |
dc.contributor.author | Gobec, Stanislav | |
dc.contributor.author | Colettis, Natalia | |
dc.contributor.author | Mander, Mariel | |
dc.date.accessioned | 2023-03-23T15:21:22Z | |
dc.date.available | 2023-03-23T15:21:22Z | |
dc.date.issued | 2023-01-01 | |
dc.identifier.issn | 1424-8247 | |
dc.identifier.other | https://doi.org/10.3390/ph16010129 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/14322 | |
dc.identifier.uri | https://www.mdpi.com/1424-8247/16/1/129 | |
dc.description.abstract | Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the ef fect of extracts obtained from endemic Argentinian species of valerians, namely V. carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC from Patagonia and V. ferax (Griseb.) Höck and V. effusa Griseb., on different AD-related biological targets. Of these anxiolytic, sedative and sleep-inducing valerians, V. carnosa proved the most promising and was assayed in vivo. All valerians inhibited acetylcholinesterase (IC50 between 1.08–12.69 mg/mL) and butyrylcholinesterase (IC50 between 0.0019–1.46 mg/mL). They also inhibited the aggregation of β-amyloid peptide, were able to chelate Fe2+ ions, and exhibited a direct relationship between antioxidant capacity and phenolic content. Moreover, V. carnosa was able to inhibit human monoamine oxidase A (IC50: 0.286 mg/mL (0.213–0.384)). A daily intake of aqueous V. carnosa extract by male Swiss mice (50 and 150 mg/kg/day) resulted in anxiolytic and antidepressant-like behavior and improved spatial memory. In addition, decreased AChE activity and oxidative stress markers were observed in treated mouse brains. Our studies contribute to the development of indigenous herbal medicines as therapeutic agents for AD. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | MDPI | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | Pharmaceuticals 16 (1) : 129 (January 2023) | es_AR |
dc.subject | Medicinal Plants | eng |
dc.subject | Plantas Medicinales | es_AR |
dc.subject | Acetylcholinesterase | eng |
dc.subject | Acetilcolinesterasa | es_AR |
dc.subject | Antioxidants | eng |
dc.subject | Antioxidantes | es_AR |
dc.subject | Monoamine Oxidase | eng |
dc.subject | Monoamina Oxidasa | es_AR |
dc.subject | Memory | eng |
dc.subject | Memoria | es_AR |
dc.subject | Valeriana | eng |
dc.subject | Argentina | |
dc.subject.other | Alzheimer´s Disease | eng |
dc.subject.other | Enfermedad de Alzheimer | es_AR |
dc.subject.other | B Amyloid Aggregation | eng |
dc.subject.other | Agregación de Amiloide B | es_AR |
dc.subject.other | Antidepressant | eng |
dc.subject.other | Antidepresivo | es_AR |
dc.title | Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | Instituto de Recursos Biológicos | |
dc.description.fil | Fil: Marcucci, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina | es_AR |
dc.description.fil | Fil: Rademacher, Marina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina | es_AR |
dc.description.fil | Fil: Kamecki, Fabiola. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina | es_AR |
dc.description.fil | Fil: Pastore, Valentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina | es_AR |
dc.description.fil | Fil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina | es_AR |
dc.description.fil | Fil: Ricco, Rafael. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmabotánica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Tecnología Farmaceutica y Biofarmacia; Argentina | es_AR |
dc.description.fil | Fil: Wagner, Marcelo L. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina | es_AR |
dc.description.fil | Fil: Knez, Damijan. University of Ljubljana; Faculty of Pharmacy, Slovenia. | es_AR |
dc.description.fil | Fil: Gobec, Stanislav. University of Ljubljana; Faculty of Pharmacy, Slovenia. | es_AR |
dc.description.fil | Fil: Colettis, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina | es_AR |
dc.description.fil | Fil: Marder, Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina | es_AR |
dc.subtype | cientifico |
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