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Background: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transposable elements called Miniature Inverted-repeat Transposable Elements (MITEs).
Results: We used public small RNA and degradome libraries from Triticum
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dc.contributor.author | Crescente, Juan Manuel | |
dc.contributor.author | Zavallo, Diego | |
dc.contributor.author | Del Vas, Mariana | |
dc.contributor.author | Asurmendi, Sebastian | |
dc.contributor.author | Helguera, Marcelo | |
dc.contributor.author | Fernandez, Elmer | |
dc.contributor.author | Vanzetti, Leonardo Sebastian | |
dc.date.accessioned | 2022-05-13T10:46:54Z | |
dc.date.available | 2022-05-13T10:46:54Z | |
dc.date.issued | 2022-02 | |
dc.identifier.issn | 1471-2164 | |
dc.identifier.other | https://doi.org/10.1186/s12864-022-08364-4 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/11871 | |
dc.identifier.uri | https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-022-08364-4 | |
dc.description.abstract | Background: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transposable elements called Miniature Inverted-repeat Transposable Elements (MITEs). Results: We used public small RNA and degradome libraries from Triticum aestivum to screen for microRNAs production and predict their cleavage target sites. In parallel, we also created a comprehensive wheat MITE database by identifying novel elements and compiling known ones. When comparing both data sets, we found high homology between MITEs and 14% of all the miRNAs production sites detected. Furthermore, we show that MITE-derived miRNAs have preference for targeting degradation sites with MITE insertions in the 3’ UTR regions of the transcripts. Conclusions: Our results revealed that MITE-derived miRNAs can underlay the origin of some miRNAs and potentially shape a regulatory gene network. Since MITEs are found in millions of insertions in the wheat genome and are closely linked to genic regions, this kind of regulatory network could have a significant impact on the post-transcriptional control of gene expression. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | BioMed Central | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/PNBIO-1131022/AR./Genómica funcional y biología de sistemas. | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/2019-PD-E6-I116-001/2019-PD-E6-I116-001/AR./Identificación y análisis funcional de genes o redes génicas de interés biotecnológico con fin agropecuario, forestal, agroalimentario y/o agroindustrial. | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | BMC Genomics 23 (1) : 154 (Febrero 2022) | es_AR |
dc.subject | MicroRNA | eng |
dc.subject | MicroARN | es_AR |
dc.subject | Triticum aestivum | es_AR |
dc.subject | Gene Expression | eng |
dc.subject | Expresión Génica | es_AR |
dc.subject | Gene Regulatory Networks | eng |
dc.subject | Redes de Regulación Génica | es_AR |
dc.subject | Trigo | |
dc.subject | Wheat | eng |
dc.subject | Trigo Harinero | |
dc.subject | Soft Wheat | eng |
dc.subject.other | Trigo Pan | |
dc.title | Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Crescente, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Zavallo, Diego. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Zavallo, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Del Vas, Mariana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Del Vas, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Asurmendi, Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Asurmendi, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Helguera, Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro de Investigaciones Agropecuarias; Argentina | es_AR |
dc.description.fil | Fil: Fernandez, Elmer. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina | es_AR |
dc.description.fil | Fil: Fernandez, Elmer. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Vanzetti, Leonardo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina | es_AR |
dc.description.fil | Fil: Vanzetti, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.subtype | cientifico |
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