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Resumen
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide.
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dc.contributor.author | Elso, Orlando G. | |
dc.contributor.author | Clavin, María | |
dc.contributor.author | Hernandez, Natalia | |
dc.contributor.author | Slargata, Tomás | |
dc.contributor.author | Bach, Hernán Gerónimo | |
dc.contributor.author | Catalan, César A.N. | |
dc.contributor.author | Aguilera, Elena | |
dc.contributor.author | Alvarez, Guzmán | |
dc.contributor.author | Sülsen, Valeria P. | |
dc.date.accessioned | 2022-04-29T09:39:06Z | |
dc.date.available | 2022-04-29T09:39:06Z | |
dc.date.issued | 2021-02-12 | |
dc.identifier.issn | 1741-427X | |
dc.identifier.issn | 1741-4288 | |
dc.identifier.other | https://doi.org/10.1155/2021/6622894 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/11763 | |
dc.identifier.uri | https://www.hindawi.com/journals/ecam/2021/6622894/ | |
dc.description.abstract | The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Hindawi | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Evidence based complementary and alternative medicine 2021 : Article ID 6622894 (2021) | es_AR |
dc.subject | Urolepis | es_AR |
dc.subject | Activity | eng |
dc.subject | Actividad | es_AR |
dc.subject | Asteraceae | |
dc.subject | Propiedades Antimicrobianas | |
dc.subject | Antimicrobial Properties | eng |
dc.subject.other | Urolepis hecatantha | |
dc.title | Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
dc.description.fil | Fil: Elso, Orlando G. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. CONICET–Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentina | es_AR |
dc.description.fil | Fil: Clavin, Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. CONICET–Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentina | es_AR |
dc.description.fil | Fil: Hernández, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. | es_AR |
dc.description.fil | Fil: Sgarlata, Tomas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. | es_AR |
dc.description.fil | Fil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina | es_AR |
dc.description.fil | Fil: Catalán, César A. N. Universidad Nacional de Tucumán. Facultad de Bioquímica Química y Farmacia. Instituto de Química Orgánica; Argentina | es_AR |
dc.description.fil | Fil: Aguilera, Elena. Universidad de la República. Facultad de Ciencias. Grupo de Química Medicinal. Laboratorio de Química Orgánica; Uruguay | es_AR |
dc.description.fil | Fil: Álvarez, Guzmán. Universidad de la República. CENUR Litoral Norte. Laboratorio de Moléculas Bioactivas; Uruguay | es_AR |
dc.description.fil | Fil: Sulsen, Valeria P. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. CONICET–Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentina | es_AR |
dc.subtype | cientifico |
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