Mostrar el registro sencillo del ítem
resumen
Resumen
Foot and Mouth Disease Virus (FMDV) causes economy losses and is controlled by vaccination in many countries. Vaccine formulations based on empty capsids or Virus-Like Particles (VLPs) have the advantage of avoiding the biological hazard of using infectious FMDV, albeit are poorly immunogenic. Recently, we have described that ISPA a new Immune Stimulating Complex adjuvant, is useful to improve the response against FMD of vaccines that use inactivated
[ver mas...]
dc.contributor.author | Bidart, Juan Esteban | |
dc.contributor.author | Mignaqui, Ana Clara | |
dc.contributor.author | Kornuta, Claudia Alejandra | |
dc.contributor.author | Lupi, Giuliana | |
dc.contributor.author | Gammella, Mariela | |
dc.contributor.author | Soria, Ivana | |
dc.contributor.author | Galarza, Roxana Ivon | |
dc.contributor.author | Ferella, Alejandra | |
dc.contributor.author | Cardillo, Sabrina Beatriz | |
dc.contributor.author | Langellotti, Cecilia Ana | |
dc.contributor.author | Quattrocchi, Valeria | |
dc.contributor.author | Durocher, Yves | |
dc.contributor.author | Wigdorovitz, Andres | |
dc.contributor.author | Marcipar, Ivan | |
dc.contributor.author | Zamorano, Patricia Ines | |
dc.date.accessioned | 2021-09-08T12:05:18Z | |
dc.date.available | 2021-09-08T12:05:18Z | |
dc.date.issued | 2021-05 | |
dc.identifier.issn | 1872-7492 | |
dc.identifier.other | https://doi.org/10.1016/j.virusres.2021.198339 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/10200 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0168170221000460 | |
dc.description.abstract | Foot and Mouth Disease Virus (FMDV) causes economy losses and is controlled by vaccination in many countries. Vaccine formulations based on empty capsids or Virus-Like Particles (VLPs) have the advantage of avoiding the biological hazard of using infectious FMDV, albeit are poorly immunogenic. Recently, we have described that ISPA a new Immune Stimulating Complex adjuvant, is useful to improve the response against FMD of vaccines that use inactivated virus. Now, the adjuvant effects of ISPA and ISA 206 (water/oil/water) on a VLPs-based FMD vaccine were evaluated. VLPs (strain A/Argentina/2001) were obtained in mammalian cell cultures and their elicitation of an immune response against FMDV with and without ISPA or ISA 206 was evaluated in mice as a first approach. Notably, VLPs-ISPA and VLPs-ISA 206 vaccines induced protection against viral challenge in 100 % of mice, while protection induced by VLPs alone was of 40 %. Total and neutralizing FMDV antibodies were higher in the VLPs-ISPA and VLPs-ISA 206 groups compared to the VLPs group. VLPs-ISPA induced significantly higher (p < 0.001) IgG1, IgG2a, IgG2b and IgG3 titers than the VLPs vaccine. Moreover, in comparison with non-adjuvanted VLPs, VLPs-ISPA and VLPs-ISA 206 elicited an increased virus-specific T response, including higher IFNγ+/CD8 + lymphocyte production in mice. When these vaccines were tested in calves, antibody titers reached an Expected Percentage of Protection (EPP) above 90 % in the case of the VLPs-ISPA and VLPs-ISA 206 vaccines, while, in the VLPs group, EPP reached 25 %. IFNγ levels secreted by mononuclear cells of VLP-ISPA-vaccinated cattle were significantly higher than in the VLPs group. Overall, the results demonstrate that VLPs-ISPA or VLPs-ISA 206 are promising formulations for the development of a novel FMD vaccine. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Elsevier | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/2019-PD-E5-I105-001/2019-PD-E5-I105-001/AR./Patógenos animales: su interacción con el hospedador y el medio ambiente. Impacto en productividad, ecosistemas, sanidad animal y salud pública en el marco “Una Salud” | |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.source | Virus Research 297 : 198339 (Mayo 2021) | es_AR |
dc.subject | Foot-and-mouth Disease | eng |
dc.subject | Fiebre Aftosa | es_AR |
dc.subject | Aphthovirus | eng |
dc.subject | Virus Fiebre Aftosa | es_AR |
dc.subject | Vaccine Adjuvants | eng |
dc.subject | Coadyuvantes de Vacunas | es_AR |
dc.subject | Immunity | eng |
dc.subject | Inmunidad | es_AR |
dc.subject | Protection | eng |
dc.subject | Protección | es_AR |
dc.title | FMD empty capsids combined with the immunostant particle adjuvant -ISPA or ISA206 induce protective immunity against foot and mouth disease virus | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.description.origen | Instituto de Virología | es_AR |
dc.description.fil | Fil: Bidart, Juan Esteban. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Bidart, Juan Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Mignaqui, Ana Clara. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina | es_AR |
dc.description.fil | Fil: Mignaqui, Ana Clara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Kornuta, Claudia Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Kornuta, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Lupi, Giuliana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina | es_AR |
dc.description.fil | Fil: Lupi, Giuliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Gammella, Mariela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Gammella, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Soria, Ivana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Soria, Ivana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Galarza, Roxana Ivon. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Galarza, Roxana Ivon. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Ferella, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Ferella, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Cardillo, Sabrina Beatriz. Biogénesis-Bagó; Argentina | es_AR |
dc.description.fil | Fil: Langellotti, Cecilia Ana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Langellotti, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Quattrocchi, Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Quattrocchi, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Durocher, Yves. Human Health Therapeutics Research Center, National Research Council Canada; Canadá | es_AR |
dc.description.fil | Fil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Wigdorovitz, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Marcipar, Ivan Sergio. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Tecnología Inmunológica; Argentina | es_AR |
dc.description.fil | Fil: Marcipar, Ivan Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Zamorano, Patricia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Zamorano, Patricia Ines. Universidad del Salvador; Argentina | es_AR |
dc.subtype | cientifico |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
common
-
Artículos científicos [199]