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Decreased immune response in undernourished rats after air pollution exposure
Abstract
Children are highly vulnerable subpopulation to malnutrition and air pollution. We investigate, in a rat nutritional growth retardation (NGR) model, the impact of Residual Oil Fly Ash (ROFA) on the lung immune response using in vitro and ex vivo methods. In vitro: Alveolar macrophages (AM) were isolated from Control (C) and NGR animals, cultured and treated with ROFA (1–100 µg/ml) for 24 h. Ex vivo: C and NGR rats were intranasally instilled with ROFA
[ver mas...]
Children are highly vulnerable subpopulation to malnutrition and air pollution. We investigate, in a rat nutritional growth retardation (NGR) model, the impact of Residual Oil Fly Ash (ROFA) on the lung immune response using in vitro and ex vivo methods. In vitro: Alveolar macrophages (AM) were isolated from Control (C) and NGR animals, cultured and treated with ROFA (1–100 µg/ml) for 24 h. Ex vivo: C and NGR rats were intranasally instilled with ROFA (1 mg/kg BW) or PBS. 24 h post-exposure AM were isolated and cultured. ROFA-treatment increased superoxide anion production and TNFα secretion in C-AM in vitro, though for NGR-AM this response was lower. A similar pattern was observed for TNFα and IL-6 secretion in ex vivo experiments. Regarding the antioxidant response, although NGR-AM showed increased Nrf2, after ROFA instillation an attenuated activation was observed. To conclude, chronic undernutrition altered AM response to ROFA affecting immune responsiveness to air pollutants.
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![Thumbnail](/bitstream/handle/20.500.12123/18349/Environmental%20Toxicology%20and%20Pharmacology-cover.gif?sequence=4&isAllowed=y)
Author
Kurtz, Melisa Lidia;
Orona, Nadia Soledad;
Lezón, Christian;
Delfosse, Veronica Cecilia;
Astort, Francisco;
Maglione, Guillermo Alberto;
Boyer, Patricia Mónica;
Tasat, Deborah Ruth;
Fuente
Environmental Toxicology and Pharmacology 107 : 104400 (April 2024)
Date
2024-04
Editorial
Elsevier
ISSN
1872-7077
Formato
pdf
Tipo de documento
artículo
Palabras Claves
Derechos de acceso
Embargado
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