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Mostrando ítems 1-7 de 7
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A new gnotobiotic pig model of P[6] human rotavirus infection and disease for preclinical evaluation of rotavirus vaccines
Nyblade, Charlotte; Hensley, Casey; Parreño, Gladys Viviana; Zhou, Peng; Frazier, Maggie; Frazier, Annie; Ramesh, Ashwin; Lei, Shaohua; Degiuseppe, Juan Ignacio; Tan, Ming; Yuan, Lijuan (MDPI, 2022-12)Human rotavirus (HRV) is a leading cause of gastroenteritis in children under 5 years of age. Licensed vaccines containing G1P[8] and G1-4P[8] strains are less efficacious against newly emerging P[6] strains, indicating ... -
Combined live oral priming and intramuscular boosting regimen with Rotarix® and a nanoparticle-based trivalent rotavirus vaccine evaluated in gnotobiotic pig models of G4P[6] and G1P[8] human rotavirus infection
Hensley, Casey; Nyblade, Charlotte; Zhou, Peng; Parreño, Gladys Viviana; Ramesh, Ashwin; Frazier, Annie; Frazier, Maggie; Garrison, Sarah; Fantasia-Davis, Ariana; Cai, Ruiqing; Huang, Peng-Wei; Xia, Ming; Tan, Ming; Yuan, Lijuan (MDPI, 2023-05)Human rotavirus (HRV) is the causative agent of severe dehydrating diarrhea in children under the age of five, resulting in up to 215,000 deaths each year. These deaths almost exclusively occur in low- and middle-income ... -
Development of nanobody-displayed whole-cell biosensors for the colorimetric detection of SARS-CoV‑2
He, Yawen; Xu, Zhiyuan; Kasputis, Tom; Zhao, Xue; Ibañez, Itati; Pavan, Florencia; Bok, Marina; Malito, Juan Pablo; Parreño, Gladys Viviana; Yuan, Lijuan; Wright, R. Clay; Chen, Juhong (American Chemical Society, 2023-08)The accurate and effective detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential to preventing the spread of infectious diseases and ensuring human health. Herein, a nanobody-displayed ... -
Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease
Nyblade, Charlotte; Parreño, Gladys Viviana; Zhou, Peng; Hensley, Casey; Oakes, Vanessa; Mahsoub, Hassan M.; Kiley, Kelsey; Frazier, Maggie; Frazier, Annie; Zhang, Yongrong; Feng, Hanping; Yuan, Lijuan (BioMed Central, 2022-06)Clostridioides difficile (C. difficile) is a gram-positive, spore-forming, anaerobic bacterium known to be the most common cause of hospital-acquired and antibiotic-associated diarrhea. C. difficile infection rates are on ... -
Feasibility of polyclonal avian immunoglobulins (IgY) as prophylaxis against human norovirus infection
Artman, Chad; Idegwu, Nnebuefe; Brumfield, Kyle D.; Lai, Ken; Hauta, Shirley; Falzarano, Darryl; Parreño, Gladys Viviana; Yuan, Lijuan; Geyer, James D.; Goepp, Julius G. (MDPI, 2022-11)Background: Human norovirus (HuNoV) is the leading viral cause of diarrhea, with GII.4 as the predominant genotype of HuNoV outbreaks globally. However, new genogroup variants emerge periodically, complicating the development ... -
Human rotavirus replicates in salivary glands and primes immune responses in facial and intestinal lymphoid tissues of gnotobiotic pigs
Nyblade, Charlotte; Zhou, Peng; Frazier, Maggie; Frazier, Annie; Hensley, Casey; Fantasia-Davis, Ariana; Shahrudin, Shabihah; Hoffer, Miranda; Agbemabiese, Chantal Ama; LaRue, Lauren; Barro, Mario; Patton, John T.; Parreño, Gladys Viviana; Yuan, Lijuan (MDPI, 2023-08)Human rotavirus (HRV) is a leading cause of viral gastroenteritis in children across the globe. The virus has long been established as a pathogen of the gastrointestinal tract, targeting small intestine epithelial cells ... -
Probiotic as adjuvant significantly improves protection of the Lanzhou trivalent rotavirus vaccine against heterologous challenge in a gnotobiotic pig model of human rotavirus infection and disease
Parreño, Gladys Viviana; Bai, Muqun; Liu, Fangning; Jing, Jiqiang; Olney, Erika; Li, Guohua; Wen, Ke; Yang, Xingdong; Castellucc, Tammy Bui; Kocher, Jacob F.; Zhou, Xu; Yuan, Lijuan (MDPI, 2022-09)This preclinical study in the gnotobiotic (Gn) pig model of human rotavirus (HRV) infection and disease evaluates the effect of probiotic Lactobacillus rhamnosus GG (LGG) as a mucosal adjuvant on the immunogenicity and ...