Mostrar el registro sencillo del ítem
resumen
Resumen
The pods of Neltuma spp. have shown potential as a source of protein and energy in livestock. However, prolonged consumption of some of these species can lead to neurological symptoms in ruminants. This study aimed to determine the alkaloid content, as well as the in vitro and in vivo effects of an alkaloid-enriched extract (AEE) from N. alpataco pods. High performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) identified
[ver mas...]
dc.contributor.author | Cholich, Luciana Andrea | |
dc.contributor.author | Pistán, Maria Elena | |
dc.contributor.author | Cabrera Benítez, Angelica | |
dc.contributor.author | Torres, Ana María | |
dc.contributor.author | Garcia, Enrique Nicolas | |
dc.contributor.author | Martinez, Agustin | |
dc.contributor.author | Gardner, Dale R. | |
dc.contributor.author | Bustillo, Soledad | |
dc.date.accessioned | 2024-03-11T11:43:44Z | |
dc.date.available | 2024-03-11T11:43:44Z | |
dc.date.issued | 2024-04 | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.issn | 1879-3150 | |
dc.identifier.other | https://doi.org/10.1016/j.toxicon.2024.107665 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/16994 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S004101012400237X | |
dc.description.abstract | The pods of Neltuma spp. have shown potential as a source of protein and energy in livestock. However, prolonged consumption of some of these species can lead to neurological symptoms in ruminants. This study aimed to determine the alkaloid content, as well as the in vitro and in vivo effects of an alkaloid-enriched extract (AEE) from N. alpataco pods. High performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) identified juliprosine and juliprosopine as primary alkaloids, with juliprosine being most abundant. AEE from N. alpataco demonstrated dose-dependent cytotoxicity on glioma cells after 48 h, with a 50% cytotoxic concentration (CC50) of 24.69 μg/mL. However, the release of LDH was observed only at the highest tested concentration, indicating cellular damage. Further examination through phase-contrast microscopy and dual acridine orange/ethidium bromide fluorescence staining revealed morphological changes consistent with an apoptotic mechanism of cell death, ultimately leading to secondary necrosis. Finally, the LD50 after intraperitoneal injection in mice was determined to be 12.98 mg/kg. Taken together, these findings demonstrated for the first time the in vivo and in vitro toxicity of the AEE from N. alpataco pods. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Elsevier | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | Toxicon 241 : 107665. (April 2024) | es_AR |
dc.subject | Prosopis | es_AR |
dc.subject | Toxicidad | es_AR |
dc.subject | Toxicity | eng |
dc.subject | Citotoxicidad | es_AR |
dc.subject | Cytotoxicity | eng |
dc.subject | Alcaloides | es_AR |
dc.subject | Alkaloids | eng |
dc.subject | Apoptosis | eng |
dc.subject.other | Neltuma alpataco | es_AR |
dc.subject.other | Prosopis alpataco | es_AR |
dc.title | Evaluation of the toxicological effects of Neltuma alpataco (Prosopis alpataco) pod alkaloid extract | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | EEA Bariloche | es_AR |
dc.description.fil | Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina | es_AR |
dc.description.fil | Fil: Cholich, Luciana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Pistán, Maria Elena. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina | es_AR |
dc.description.fil | Fil: Pistán, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Cabrera Benítez, Angelica. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina | es_AR |
dc.description.fil | Fil: Torres, Ana María. Universidad Nacional del Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Laboratorio de Productos Naturales; Argentina | es_AR |
dc.description.fil | Fil: Torres, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Básica y Aplicada del Nordeste Argentino. Laboratorio de Productos Naturales; Argentina | es_AR |
dc.description.fil | Fil: Garcia, Enrique Nicolas. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina | es_AR |
dc.description.fil | Fil: Martinez, Agustin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina | es_AR |
dc.description.fil | Fil: Gardner, Dale R. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos | es_AR |
dc.description.fil | Fil: Bustillo, Soledad. Universidad Nacional del Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Grupo de Investigaciones Biológicas y Moleculares; Argentina | es_AR |
dc.description.fil | Fil: Fil: Bustillo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Básica y Aplicada del Nordeste Argentino. Grupo de Investigaciones Biológicas y Moleculares; Argentina | es_AR |
dc.subtype | cientifico |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
common
-
Artículos científicos [565]