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While RNA viruses thrive with massive structural and functional diversity, their genomes size variation is particularly low, ranging only from ~2-to-33 kb. Here, I present the characterization of RNA sequences corresponding to the first virus associated with Aplysia californica. Genome structure and domain architecture suggest that the identified virus is a novel member of Nidovirales. The proposed aplysia californica nido-like virus (AcNV), with a genome
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dc.contributor.author | Debat, Humberto Julio | |
dc.date.accessioned | 2022-06-16T10:39:56Z | |
dc.date.available | 2022-06-16T10:39:56Z | |
dc.date.issued | 2018-04-24 | |
dc.identifier.other | https://doi.org/10.1101/307678 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/12109 | |
dc.identifier.uri | https://www.biorxiv.org/content/10.1101/307678v1 | |
dc.description.abstract | While RNA viruses thrive with massive structural and functional diversity, their genomes size variation is particularly low, ranging only from ~2-to-33 kb. Here, I present the characterization of RNA sequences corresponding to the first virus associated with Aplysia californica. Genome structure and domain architecture suggest that the identified virus is a novel member of Nidovirales. The proposed aplysia californica nido-like virus (AcNV), with a genome sequence of ca.35,906 nt, represents the longest ever recorded RNA virus yet. Phylogenetic insights indicate that AcNV clusters in a major phylloclade of unclassified invertebrate nidoviruses, Roniviridae, and Mesoniviridae. Basal branching in this emerging cluster could indicate that AcNV is a member of a novel divergent clade within Nidovirales. Further, virus RNA detection in multiple independent studies suggests that AcNV is neurotropic with a broad cell/tissue/organ tropism, supported by AcNV occurrence in diverse organs, including the first detection of a Nidovirales in single specific neurons. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | BioRxiv | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | BioRxiv : the preprint server for biology (April 24, 2018) | es_AR |
dc.subject | Nidovirales | eng |
dc.subject | RNA Viruses | eng |
dc.subject | Virología | es_AR |
dc.subject.other | Aplysia Californica | es_AR |
dc.subject.other | Virus Discovery | eng |
dc.subject.other | Single-Cell Virology | eng |
dc.subject.other | Neurotropic Virus | eng |
dc.title | Expanding the size limit of RNA viruses: Evidence of a novel divergent nidovirus in California sea hare, with a ~35.9 kb virus genome | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/acceptedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
dc.description.origen | Instituto de Patología Vegetal | es_AR |
dc.description.fil | Fil: Debat, Humberto Julio. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patología Vegetal; Argentina | es_AR |
dc.subtype | cientifico |
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