Ver ítem
- xmlui.general.dspace_homeCentros e Institutos de InvestigaciónCIRN. Centro de Investigaciones de Recursos NaturalesInstituto de Recursos BiológicosArtículos científicosxmlui.ArtifactBrowser.ItemViewer.trail
- Inicio
- Centros e Institutos de Investigación
- CIRN. Centro de Investigaciones de Recursos Naturales
- Instituto de Recursos Biológicos
- Artículos científicos
- Ver ítem
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)
Resumen
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide.
[ver mas...]
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.
[Cerrar]
Autor
Elso, Orlando G.;
Clavin, María;
Hernandez, Natalia;
Slargata, Tomás;
Bach, Hernán Gerónimo;
Catalan, César A.N.;
Aguilera, Elena;
Alvarez, Guzmán;
Sülsen, Valeria P.;
Fuente
Evidence based complementary and alternative medicine 2021 : Article ID 6622894 (2021)
Fecha
2021-02-12
Editorial
Hindawi
ISSN
1741-427X
1741-4288
1741-4288
Formato
pdf
Tipo de documento
artículo
Palabras Claves
Derechos de acceso
Abierto
Excepto donde se diga explicitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)