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Resumen
Varicellovirus bovinealpha 1 (formerly bovine alphaherpesvirus type 1, BoAHV-1) is associated with several syndromes in cattle, including respiratory disease and is one of the main agents involved in the bovine respiratory disease complex (BRDC). Its infectious cycle is characterized by latent infections with sporadic virus reactivation and transmission. Although the acute disease can be prevented by the use of vaccines, specific therapeutic measures are
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dc.contributor.author | Pérez, Sandra | |
dc.contributor.author | Miró, María Victoria | |
dc.contributor.author | Verna, Andrea Elizabeth | |
dc.contributor.author | González Altamiranda, Erika | |
dc.contributor.author | Barcos, Oscar | |
dc.contributor.author | Lanusse, Carlos Edmundo | |
dc.contributor.author | Lifschitz, Adrián Luia | |
dc.date.accessioned | 2024-03-12T17:47:52Z | |
dc.date.available | 2024-03-12T17:47:52Z | |
dc.date.issued | 2024-01 | |
dc.identifier.issn | 1432-072X (online) | |
dc.identifier.issn | 0302-8933 (print) | |
dc.identifier.other | https://doi.org/10.1007/s00203-023-03806-3 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/17008 | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00203-023-03806-3 | |
dc.description.abstract | Varicellovirus bovinealpha 1 (formerly bovine alphaherpesvirus type 1, BoAHV-1) is associated with several syndromes in cattle, including respiratory disease and is one of the main agents involved in the bovine respiratory disease complex (BRDC). Its infectious cycle is characterized by latent infections with sporadic virus reactivation and transmission. Although the acute disease can be prevented by the use of vaccines, specific therapeutic measures are not available. Ivermectin (IVM) is a semi-synthetic avermectin with a broad-spectrum antiparasitic activity, which has previously shown to have potential as an antiviral drug. In this study, IVM antiviral activity against BoAHV-1 was characterized in two cell lines (MDBK [Madin Darby bovine kidney] and BT [bovine turbinate]), including the measurement of intracellular drug accumulation within virus-infected cells. IVM antiviral activity was assessed at three different drug concentrations (1.25, 2.5 and 5 µM) after incubation for 24, 48 and 72 h. Slight cytotoxicity was only observed with 5 µM IVM. Even the lowest IVM dose was able to induce a significant reduction in virus titers in both cell lines. These findings indicate that the antiviral effects of IVM were evident in our experimental model within the range of concentrations achievable through therapeutic in vivo administration. Consequently, additional in vivo trials are necessary to validate the potential utility of these results in effectively managing BoAHV-1 in infected cattle. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Springer | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | Archives of Microbiology 206 : 78 (January 2024). | es_AR |
dc.subject | Ganado Bovino | es_AR |
dc.subject | Cattle | eng |
dc.subject | Herpes Virus Bovino | es_AR |
dc.subject | Bovine Herpesvirus | eng |
dc.subject | Ivermectina | es_AR |
dc.subject | Ivermectin | eng |
dc.subject | Herpesviridae | eng |
dc.subject | Medicamentos | es_AR |
dc.subject | Drugs | eng |
dc.title | Ivermectin antiviral activity against Varicellovirus bovinealpha 1: assessment of intracellular drug accumulation in virus‑infected cells | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/pubishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | EEA Balcarce | es_AR |
dc.description.fil | Fil: Pérez, Sandra. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. | es_AR |
dc.description.fil | Fil: Pérez, Sandra. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Comisión de Investigaciones Científicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. | es_AR |
dc.description.fil | Fil: Miró, María Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Comisión de Investigaciones Científicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. | es_AR |
dc.description.fil | Fil: Verna, Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. | es_AR |
dc.description.fil | Fil: Gonzalez Altamiranda, Erika. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. | es_AR |
dc.description.fil | Fil: Barcos, Oscar. Laboratorio Colón; Argentina. | es_AR |
dc.description.fil | Fil: Lanusse, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. | es_AR |
dc.description.fil | Fil: Lanusse, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Comisión de Investigaciones Científicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. | es_AR |
dc.description.fil | Fil: Lifschitz, Adrián. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. | es_AR |
dc.description.fil | Fil: Lifschitz, Adrián. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Comisión de Investigaciones Científicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. | es_AR |
dc.subtype | cientifico |
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