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A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice
Montenegro, Valeria Noely; Jaramillo Ortiz, Jose; Paoletta, Martina; Gravisaco, María José; Del Medico Zajac, Maria Paula; Garanzini, Debora Patricia; Valenzano, Magali Nicole; Calamante, Gabriela; Wilkowsky, Silvina Elizabeth (Elsevier, 2022-09)In the intraerythrocytic protozoan parasites of the genus Babesia both innate and adaptive immune responses are necessary to confer protection against clinical disease. In particular, the adaptive immune response involves ... -
Diversity of the BoLA-DRB3 gene in cattle breeds from tropical and subtropical regions of Argentina
Valenzano, Magali Nicole; Caffaro, María Eugenia; Lia, Veronica Viviana; Poli, Mario Andres; Wilkowsky, Silvina Elizabeth (Springer, 2021-12)Bovine leukocyte antigens (BoLA) have been widely studied because of their primary function in the recognition of pathogens by the immune system. To date, however, the characterization of the BoLA-DRB3 gene in Latin American ... -
Immunisation of cattle against Babesia bovis combining a multi-epitope modified vaccinia Ankara virus and a recombinant protein induce strong Th1 cell responses but fails to trigger neutralising antibodies required for protection
Jaramillo Ortiz, Jose Manuel; Paoletta, Martina; Gravisaco, María José; Lopez Arias, Ludmila Sol; Montenegro, Valeria Noely; De La Fourniere, Sofia; Valenzano, Magali Nicole; Guillemi, Eliana Carolina; Valentini, Beatriz Susana; Echaide, Ignacio Eduardo; Farber, Marisa Diana; Wilkowsky, Silvina Elizabeth (Elsevier, 2019-10)Protection against the intraerythrocytic protozoan parasite Babesia bovis depends on both strong innate and adaptive immune response, this latter involving the presentation of parasite antigens to CD4+ T-lymphocytes by ... -
Predicción integral de epitopes T del parásito intracelular Babesia bovis mediante herramientas inmunoinformáticas e inmunoproteómicas
Valenzano, Magali Nicole (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2023-08)La Babesiosis bovina es una infección causada por los parásitos protozoarios Babesia bovis y B. bigemina. Ambas especies son transmitidas por garrapatas que habitan en el NOA y NEA y ocasionan importantes pérdidas económicas ...